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Press Release

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Amgen's First Quarter 2008 Adjusted Earnings Per Share Increased 4 percent to $1.12First Quarter 2008 Revenue Decreased 2 percent to $3.6 Billion
First Quarter 2008 GAAP Earnings Per Share Increased 11 percent to $1.04

THOUSAND OAKS, Calif., Apr 24, 2008 (BUSINESS WIRE) -- Amgen (NASDAQ:AMGN) reported adjusted earnings per share (EPS), excluding stock option expense and certain other expenses, of $1.12 for the first quarter of 2008, an increase of 4 percent compared to $1.08 for the first quarter of 2007. Adjusted net income, excluding stock option expense and certain other expenses, decreased 4 percent to $1,218 million in the first quarter of 2008 compared to $1,270 million in the first quarter of 2007. Stock option expense on a per share basis totaled 2 cents and 3 cents for the first quarter of 2008 and 2007, respectively.

Total revenue decreased 2 percent during the first quarter of 2008 to $3,613 million versus $3,687 million in the first quarter of 2007.

Adjusted EPS and adjusted net income for the first quarter 2008 and 2007 exclude, for the applicable periods, stock option expense, certain expenses related to acquisitions, restructuring charges and certain other items. These expenses and other items are itemized on the attached reconciliation tables. Adjusted EPS including the impact of stock option expense are also itemized in the notes to the attached reconciliation tables.

On a reported basis and calculated in accordance with United States (U.S.) Generally Accepted Accounting Principles (GAAP), Amgen's GAAP EPS were $1.04 in the first quarter of 2008, an 11 percent increase compared to $0.94 in the same quarter last year. GAAP net income increased 2 percent to $1,136 million in the first quarter of 2008 from $1,111 million in the first quarter of 2007.

"Though first quarter product sales were mixed, based on current trends and expectations, we are confident that revenues for the year will be within our previously announced guidance," said Kevin Sharer, chairman and CEO. "We continue to be encouraged by the lasting effects of our cost management efforts. These combined with our revenue and expense expectations place us solidly within our adjusted EPS guidance for the year. Most importantly, we will sustain a strong R&D investment as we look forward to disclosing important clinical data in the next 6 to 12 months."

Product Sales Performance

During the first quarter of 2008, total product sales decreased 1 percent to $3,537 million from $3,565 million in the first quarter of 2007. Sales in the U.S. totaled $2,788 million, a decrease of 3 percent versus $2,884 million in the first quarter of 2007. International sales increased 10 percent to $749 million versus $681 million for the first quarter of 2007. Changes in foreign exchange positively impacted first quarter 2008 international sales by $72 million. Excluding the impact of foreign exchange, total product sales decreased 3 percent and international product sales decreased 1 percent.

Worldwide sales of Aranesp(R) (darbepoetin alfa) decreased 25 percent to $761 million in the first quarter of 2008 versus $1,020 million during the first quarter of 2007. This decline was principally driven by U.S. Aranesp sales, which were $405 million in the first quarter of 2008 versus $654 million in the first quarter of the prior year, a decrease of 38 percent. This decline reflects the negative impact on demand, primarily in the supportive cancer care setting, of ongoing regulatory and reimbursement changes that were principally realized in the second half of 2007. This decline was partially offset by a slight benefit from a change in accounting estimates related to sales return reserves. International Aranesp sales decreased 3 percent to $356 million versus $366 million in the first quarter of 2007, reflecting continued ESA (erythropoiesis stimulating agent) dosing conservatism and pricing pressure, partially offset by changes in foreign exchange which positively impacted first quarter 2008 sales by approximately $35 million. Excluding the impact of foreign exchange, worldwide Aranesp sales decreased 29 percent and international Aranesp sales decreased 12 percent.

Sales of EPOGEN(R) (Epoetin alfa) decreased 11 percent to $554 million in the first quarter of 2008 versus $625 million in the first quarter of 2007. This decline was primarily driven by a reduction in dose / utilization due to ESA label changes and Erythropoietin Monitoring Policy (EMP) implementation, as well as unfavorable revised estimates of dialysis demand (primarily spillover) for prior quarters and unfavorable wholesaler inventory changes. The Company believes that pronounced dose declines which have been observed in the quarter of EMP implementation will moderate in subsequent quarters, as has been observed with prior years' EMP changes. As a result, the Company anticipates that full year 2008 Epogen sales will decline only slightly considering the full year dose effect will be partially offset by normal patient population growth of approximately 3 percent. Spillover is a result of the Company's contractual relationship with Johnson & Johnson. (Please refer to the Company's Form 10-K for a more detailed discussion of this relationship and a description of spillover).

Combined worldwide sales of Neulasta(R) (pegfilgrastim) and NEUPOGEN(R) (Filgrastim), increased 7 percent to $1,086 million in the first quarter of 2008 versus $1,018 million for the first quarter of 2007, driven by increased demand for Neulasta. Combined sales of Neulasta and NEUPOGEN in the U.S. were $792 million in the first quarter of 2008 versus $777 million in the first quarter of 2007, an increase of 2 percent primarily reflecting an increase in demand for Neulasta, partially offset by unfavorable wholesaler inventory changes. Combined international sales increased 22 percent to $294 million in the first quarter of 2008 versus $241 million for the same quarter in the prior year. This growth reflects changes in foreign exchange which positively impacted first quarter 2008 combined international sales by approximately $28 million, as well as increased demand driven by the continued conversion from NEUPOGEN to Neulasta. Excluding the impact of foreign exchange, combined worldwide sales increased 4 percent and combined international product sales increased 10 percent.

Sales of Enbrel(R) (etanercept) increased 30 percent in the first quarter to $951 million versus $730 million during the same period in 2007. This increase includes wholesaler inventory loading of approximately $120 million resulting from the shift to wholesaler distribution in the first quarter of 2008. This increase also reflects higher demand due to increases in both patients and average net sales price. Sales growth continued in both rheumatology and dermatology, and ENBREL continues to maintain a leading position in both segments. However, ENBREL sales growth in the first quarter was affected by slight share declines in the U.S. in both segments versus the first quarter of 2007 due to increased competitive activity.

Worldwide sales of Sensipar(R) (cinacalcet HCl) increased 27 percent to $133 million in the first quarter of 2008 versus $105 million during the first quarter of 2007. This growth was principally driven by demand, primarily due to segment penetration.

Vectibix(R) (panitumumab) sales for the first quarter were $34 million compared to $51 million in the first quarter of 2007. This decline in sales was driven primarily by demand.

Operating Expense Analysis on an Adjusted Basis:

Cost of sales decreased 3 percent to $542 million in the first quarter of 2008 versus $559 million in the first quarter of 2007. This decrease was primarily driven by lower sales volume.

Research & Development (R&D) expenses decreased 18 percent to $661 million in the first quarter of 2008 versus $803 million in the first quarter of 2007. This decrease was primarily driven by lower staff-related costs and other expense reductions resulting from the previously announced restructuring plan, cost recoveries derived from licensing transactions with Daiichi Sankyo and Takeda in Japan and lower clinical trial costs. Staff-related and other expense reductions make up approximately one half of the decline in R&D expense while the remainder of the decline is evenly divided between cost recoveries and lower clinical trial costs. Clinical trial costs decreased as some of the Company's large clinical trials completed enrollment and the significant costs associated with site initiation and patient enrollment are no longer being incurred. Full year 2008 adjusted R&D expense dollars are expected to be similar to 2007 as the Company will record a $100 million upfront payment as an R&D expense in the second quarter of 2008 for the recent Kyowa Hakko collaboration and will initiate several new clinical trials in the second half of the year.

Selling, General & Administrative (SG&A) expenses increased 15 percent to $862 million in the first quarter of 2008 versus $748 million in the first quarter of 2007. Approximately three quarters of the increase was driven by higher Wyeth profit share expenses due to higher ENBREL sales. Wyeth profit share expenses were approximately one third of SG&A expenses in the first quarter of 2008 versus approximately 30 percent of SG&A expenses in the first quarter of 2007. Excluding Wyeth profit share, SG&A expenses in the first quarter of 2008 increased 6 percent versus the first quarter of 2007. This increase is due to timing of spend and is not incremental for the year. Consistent with previously issued guidance, the Company expects 2008 adjusted SG&A expense dollars excluding Wyeth profit share expenses to be similar to 2007.

During the first quarter of 2008, adjusted EPS grew 4 percent while revenue decreased 2 percent. Adjusted EPS leverage of 6 percentage points for the first quarter was principally driven by fewer shares used in the computation of adjusted diluted EPS partially offset by higher interest expense and a higher adjusted tax rate due to the expiration of the federal R&D tax credit.

Average diluted shares for adjusted EPS in the first quarter of 2008 were 1,091 million versus 1,172 million in the first quarter of 2007.

Capital expenditures for the first quarter of 2008 were approximately $170 million versus $325 million in the first quarter of 2007. Worldwide cash and marketable securities were $8.6 billion and debt was $11.2 billion at the end of the first quarter of 2008.

The Company reaffirmed its 2008 Revenue guidance range of $14.2 billion to $14.6 billion and its 2008 adjusted EPS guidance range of $4.00 to $4.30 excluding stock option expense and certain other expenses.

First Quarter Product and Pipeline Update

The Company provided updates on selected products and late-stage clinical programs including Aranesp, Nplate(TM) (romiplostim), denosumab, Vectibix and certain emerging clinical programs.

Aranesp: The Company noted that, as a result of the March 13, 2008 Oncologic Drugs Advisory Committee (ODAC) meeting, it is in labeling discussions with the Food and Drug Administration (FDA). In addition, the Data Safety Monitoring Committee for TREAT (Trial to Reduce cardiovascular Events with Aranesp Therapy) recently completed another interim analysis (60 percent of events experienced) and recommended the study continue as planned without modification. The Company also announced that the Phase 3 Aranesp RED-HF (Reduction of Events with Darbepoetin alfa in Heart Failure) Trial(TM) completed another Data Safety Monitoring Committee review and is continuing as planned.

Nplate: The Company noted that the Prescription Drug User Fee Act (PDUFA) date is July 23, 2008. Nplate is under review for the treatment of thrombocytopenia in adult patients with chronic immune (idiopathic) thrombocytopenic purpura (ITP).

Denosumab: The denosumab program remains on track with three Phase 3 studies having met primary and all secondary endpoints. The Company continues to expect to review the entire postmenopausal osteoporosis (PMO) data set, including the pivotal fracture study in PMO, in the second half of 2008. In addition, the Company announced that its Phase 3 Breast Cancer and Solid Tumor studies to prevent skeletal related events (SRE) have fully enrolled, and the Company is increasing the enrollment size of its Phase 3 Prostate Cancer SRE study which is expected to accelerate study completion.

Vectibix: The Company announced that its Phase 3 studies of Vectibix in the treatment of 1st and 2nd-line colorectal cancer completed enrollment. In addition, Vectibix received approval in Canada as a monotherapy for the treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma with non-mutated (wild-type) KRAS after failure of fluoropyrimidine, oxaliplatin and irinotecan-containing chemotherapy regimens.

Emerging Pipeline: The Company provided an update on several of its emerging clinical programs, in particular:

AMG 108: The Company discussed results from its recently completed Phase 2 study in Rheumatoid Arthritis (RA). AMG 108 appeared to be well tolerated and showed a statistically significant improvement in the signs and symptoms of RA. However, the efficacy profile based on the results of this study was not comparable to the current standard of care for biologic therapies. The Company is evaluating other options for the overall development program. AMG 108 is a fully human monoclonal antibody that targets inhibition of the action of interleukin-1, a cytokine known to play a role in the joint destruction associated with RA.

AMG 222: The Company expects results from an ongoing Phase 2a study being conducted in collaboration with Servier, which owns the rights outside the U.S., in late 2008 or early 2009. AMG 222 targets inhibition of DPP-IV for the treatment of type II diabetes.

AMG 223: The Company announced that it is expecting data in the fourth quarter of 2008 from an expanded Phase 2 dose-ranging study prior to initiating Phase 3 development. AMG 223 is a novel polymeric phosphate binder being evaluated for the treatment of hyperphosphatemia in patients with chronic kidney disease on hemodialysis.

AMG 317: The Company expects to review Phase 2 data in the fourth quarter of 2008. AMG 317 is a fully human monoclonal antibody that is under investigation for its ability to block the actions of interleukin-4 and interleukin-13, two cytokines that are believed to play a role in asthma.

AMG 761: The Company in-licensed an anti-CCR4 humanized monoclonal antibody from Kyowa Hakko. AMG 761/KW-0761 is currently being studied in inflammation and oncology settings. Amgen has acquired rights in all non-oncology indications, while Kyowa Hakko will continue its development activities in oncology until the completion of Phase 2a. At that time, Amgen may elect to expand its license to include oncology and assume the development and commercialization of KW-0761 in oncology settings.

For more product information or the full prescribing information, please refer to the Amgen Web site at www.amgen.com.

As previously announced, the Company has posted in the Investors section of the Company's Web site (www.amgen.com/investors) a slide presentation related to its first quarter financial results conference call, scheduled for 2 p.m. Pacific Time today. The conference call will be broadcast over the Internet and can also be found on Amgen's Web site at the above web address.

Non-GAAP Financial Measures

Management has presented its operating results in accordance with GAAP and on an "adjusted" (or non-GAAP basis) for the three months ended March 31, 2008 and 2007. The Company believes that the presentation of non-GAAP financial measures provides useful supplementary information to and facilitates additional analysis by investors. The Company uses these non-GAAP financial measures in connection with its own budgeting and financial planning. These non-GAAP financial measures are in addition to, not a substitute for, or superior to, measures of financial performance prepared in conformity with U.S. GAAP.

Forward-Looking Statements

This news release contains forward-looking statements that involve significant risks and uncertainties, including those discussed below and others that can be found in our Form 10-K for the year ended Dec. 31, 2007, and in our periodic reports on Form 10-Q and Form 8-K. Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise.

No forward-looking statement can be guaranteed and actual results may differ materially from those we project. The Company's results may be affected by our ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments (domestic or foreign) involving current and future products, sales growth of recently launched products, competition from other products (domestic or foreign) and difficulties or delays in manufacturing our products. In addition, sales of our products are affected by reimbursement policies imposed by third-party payors, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and health care cost containment as well as U.S. legislation affecting pharmaceutical pricing and reimbursement. Government and others' regulations and reimbursement policies may affect the development, usage and pricing of our products. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. We or others could identify safety, side effects or manufacturing problems with our products after they are on the market. Our business may be impacted by government investigations, litigation and product liability claims. Further, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors. We depend on third parties for a significant portion of our manufacturing capacity for the supply of certain of our current and future products and limits on supply may constrain sales of certain of our current products and product candidate development. In addition, we compete with other companies with respect to some of our marketed products as well as for the discovery and development of new products. Discovery or identification of new product candidates cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate will be successful and become a commercial product. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers.

About Amgen

Amgen discovers, develops, manufactures and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science's promise by bringing safe and effective medicines from lab, to manufacturing plant, to patient. Amgen therapeutics have changed the practice of medicine, helping millions of people around the world in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. With a deep and broad pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people's lives. To learn more about our pioneering science and our vital medicines, visit www.amgen.com.

Amgen Inc.
Condensed Consolidated Statements of Income and
Reconciliation of GAAP Earnings to "Adjusted" Earnings
(In millions, except per share data)
(Unaudited)


                                       Three Months Ended
                                         March 31, 2008
                                ---------------------------------
                                 GAAP  Adjustments     "Adjusted"
                                ---------------------------------
Revenues:
 Product sales                  $3,537      $   -          $3,537
 Other revenues                     76          -              76
                                ------ -----------     ----------
  Total revenues                 3,613          -           3,613
                                ------ -----------     ----------

Operating expenses:
 Cost of sales (excludes
  amortization of acquired
  intangible assets presented
  below)                           546         (3) (a)        542
                                               (1) (b)

 Research and development          694        (12) (a)        661
                                               (2) (b)
                                              (18) (c)
                                               (1) (d)
 Selling, general and
  administrative                   874        (13) (a)        862
                                                1  (b)
 Amortization of intangible
  assets                            74        (74) (e)          -
 Other                              10        (10) (b)          -
                                ------ -----------     ----------
  Total operating expenses       2,198       (133)          2,065
                                ------ -----------     ----------

Operating income                 1,415        133           1,548

Interest and other income and
 (expense), net                     22          -              22
                                ------ -----------     ----------

Income before income taxes       1,437        133           1,570

Provision for income taxes         301         51  (i)        352
                                ------ -----------     ----------

Net income                      $1,136      $  82          $1,218
                                ====== ===========     ==========

Earnings per share:
 Basic                          $ 1.04                     $ 1.12
 Diluted (k)                    $ 1.04                     $ 1.12 (a)

Average shares used in
 calculation of earnings per
 share:
 Basic                           1,089                      1,089
 Diluted (k)                     1,092                      1,091 (a)


                                        Three Months Ended
                                          March 31, 2007
                                ----------------------------------
                                 GAAP   Adjustments     "Adjusted"
                                ----------------------------------
Revenues:
 Product sales                  $3,565       $   -          $3,565
 Other revenues                    122           -             122
                                ------- -----------     ----------
  Total revenues                 3,687           -           3,687
                                ------- -----------     ----------

Operating expenses:
 Cost of sales (excludes
  amortization of acquired
  intangible assets presented
  below)                           592          (1) (a)        559
                                                (6) (f)
                                               (26) (g)
 Research and development          851         (27) (a)        803
                                               (19) (c)
                                                (2) (d)

 Selling, general and
  administrative                   770         (22) (a)        748

 Amortization of intangible
  assets                            74         (74) (e)          -
 Other                               -           -               -
                                ------- -----------     ----------
  Total operating expenses       2,287        (177)          2,110
                                ------- -----------     ----------

Operating income                 1,400         177           1,577

Interest and other income and
 (expense), net                     (6)         51  (h)         45
                                ------- -----------     ----------

Income before income taxes       1,394         228           1,622

Provision for income taxes         283          69  (j)        352
                                ------- -----------     ----------

Net income                      $1,111       $ 159          $1,270
                                ======= ===========     ==========

Earnings per share:
 Basic                          $ 0.95                      $ 1.09
 Diluted (k)                    $ 0.94                      $ 1.08 (a)

Average shares used in
 calculation of earnings per
 share:
 Basic                           1,167                       1,167
 Diluted (k)                     1,177                       1,172 (a)


(a) - (k) See explanatory notes on the following pages.

Amgen Inc.
Notes to Reconciliation of GAAP Earnings to "Adjusted" Earnings
(In millions, except per share data)
(Unaudited)

(a) To exclude the impact of stock option expense recorded in
     accordance with Statement of Financial Accounting Standards
     ("SFAS") No. 123R. For the three months ended March 31, 2008 and
     2007, the total pre-tax expense for employee stock options in
     accordance with SFAS No. 123R was $28 million and $50 million,
     respectively.

    "Adjusted" diluted EPS including the impact of stock option
     expense for the three months ended March 31, 2008 and 2007 was as
     follows:

                                                Three Months Ended
                                                     March 31,
                                             -------------------------
                                                 2008         2007
                                             -------------------------

    "Adjusted" diluted EPS, excluding stock
     option expense                          $      1.12  $      1.08

     Impact of stock option expense                (0.02)       (0.03)
                                             ------------ ------------

    "Adjusted" diluted EPS, including stock
     option expense                          $      1.10  $      1.05
                                             ============ ============


(b) To exclude the following restructuring (expenses)/income
     associated with our restructuring plan, as follows (in millions):

                                          Asset
    Three Months Ended      Separation   Impairment
    March 31, 2008           Costs (1)      (2)     Other (3)  Total
    ----------------------- ----------- ----------- --------- --------

    Cost of sales
     (excluding
     amortization of
     intangible assets)     $        -  $       (1) $      -  $    (1)
    Research and
     development (R&D)              (2)          -         -       (2)
    Selling, general and
     administrative (SG&A)           -           -         1        1
    Other                           (4)         (2)       (4)     (10)
                            ----------- ----------- --------- --------
                            $       (6) $       (3) $     (3) $   (12)
                            =========== =========== ========= ========

    (1) Severance and other related costs.

    (2) Asset impairment charges incurred in connection with the
         rationalization of our worldwide manufacturing operations.

    (3) Cost recoveries for certain restructuring expenses in
         connection with our co-promotion agreement with Wyeth and
         other various charges.


(c) To exclude for the applicable periods the ongoing, non-cash
     amortization of the R&D technology intangible assets acquired
     with the acquisition of Abgenix, Inc. ("Abgenix") and Avidia,
     Inc. ("Avidia").

(d) To exclude for the applicable periods merger related expenses
     incurred due to the Alantos Pharmaceutical Holding, Inc., and
     Tularik Inc. acquisitions, primarily related to incremental costs
     associated with retention. Substantially all related amounts have
     been incurred.

(e) To exclude the ongoing, non-cash amortization of acquired product
     technology rights, primarily ENBREL, related to the Immunex
     Corporation acquisition.

(f) To exclude merger related expenses incurred due to the Abgenix
     acquisition, primarily related to incremental costs associated
     with recording inventory acquired at fair value which is in
     excess of our manufacturing cost.

(g) To exclude the impact of writing-off the cost of a semi-completed
     manufacturing asset that will not be used due to a change in
     manufacturing strategy.

(h) To exclude the pro rata portion of the deferred financing and
     related costs that were immediately charged to interest expense
     as a result of certain holders of our convertible notes due in
     2032 exercising their March 1, 2007 put option and the related
     convertible notes being repaid in cash.

(i) To reflect the tax effect of the above adjustments for 2008,
     excluding certain of the restructuring charges (see (b) above).

(j) To reflect the tax effect of the above adjustments for 2007,
     excluding the write-off of the cost of a semi-completed
     manufacturing asset (see (g) above).

(k) The following table presents the computations for GAAP and
     "Adjusted" diluted earnings per share, computed under the
     treasury stock method. "Adjusted" earnings per share presented
     below excludes stock option expense:


                                Three Months        Three Months
                                    Ended               Ended
                               March 31, 2008      March 31, 2007
                              -----------------   -----------------
                               GAAP  "Adjusted"    GAAP  "Adjusted"
                              -----------------   -----------------
    Income (Numerator):
     Net income for basic and
      diluted EPS             $1,136   $  1,218   $1,111   $  1,270
                              ====== ==========   ====== ==========

    Shares (Denominator):
     Weighted-average shares
      for basic EPS            1,089      1,089    1,167      1,167
     Effect of dilutive
      securities                   3          2(A)    10          5(A)
                              ------ ----------   ------ ----------
     Weighted-average shares
      for diluted EPS          1,092      1,091    1,177      1,172
                              ====== ==========   ====== ==========

    Diluted earnings per
     share                    $ 1.04   $   1.12   $ 0.94   $   1.08
                              ====== ==========   ====== ==========

(A) Dilutive securities used to compute "Adjusted" diluted earnings
     per share for the three months ended March 31, 2008 and 2007 were
     computed exclusive of the methodology used to determine dilutive
     securities under SFAS No. 123R.


Amgen Inc.
Product Sales Detail by Product and Geographic Region
(In millions)
(Unaudited)


                                                    Three Months Ended
                                                        March 31,
                                                      2008      2007
                                                    ------------------

Aranesp(R) - U.S                                    $     405 $    654

Aranesp(R) - International                                356      366

EPOGEN(R) - U.S                                           554      625

Neulasta(R) - U.S                                         569      573

NEUPOGEN(R) - U.S                                         223      204

Neulasta(R) - International                               187      146

NEUPOGEN(R) - International                               107       95

Enbrel(R) - U.S                                           904      693

Enbrel(R) - International                                  47       37

Sensipar(R) - U.S                                          93       77

Sensipar(R) - International                                40       28

Vectibix(R) - U.S                                          32       51

Vectibix(R) - International                                 2        -

Other product sales - U.S                                   8        7

Other product sales - International                        10        9
                                                    --------- --------

 Total product sales                                $   3,537 $  3,565
                                                    ========= ========


U.S                                                 $   2,788 $  2,884

International                                             749      681
                                                    --------- --------

 Total product sales                                $   3,537 $  3,565
                                                    ========= ========

Amgen Inc.
Condensed Consolidated Balance Sheets - GAAP
(In millions)
(Unaudited)

                                           March 31,      December 31,
                                              2008            2007
                                          ------------    ------------
Assets
Current assets:
 Cash, cash equivalents and marketable
  securities                                   $ 8,647         $ 7,151
 Trade receivables, net                          2,224           2,101
 Inventories                                     2,091           2,091
 Other current assets                            1,565           1,698
                                          ------------    ------------
  Total current assets                          14,527          13,041
Property, plant and equipment, net               5,949           5,941
Intangible assets, net                           3,271           3,332
Goodwill                                        11,347          11,240
Other assets                                     1,034           1,085
                                          ------------    ------------
  Total assets                                 $36,128         $34,639
                                          ============    ============

Liabilities and Stockholders' Equity
Current liabilities:
 Accounts payable and accrued liabilities      $ 3,954         $ 4,179
 Current portion of other long-term debt         2,000           2,000
                                          ------------    ------------
  Total current liabilities                      5,954           6,179
Deferred tax liabilities                           381             480
Convertible notes                                5,080           5,080
Other long-term debt                             4,097           4,097
Other non-current liabilities                    1,529             934
Stockholders' equity                            19,087          17,869
                                          ------------    ------------
  Total liabilities and stockholders'
   equity                                      $36,128         $34,639
                                          ============    ============

Shares outstanding                               1,088           1,087

Amgen Inc.
Reconciliation of "Adjusted" Earnings Per Share Guidance to GAAP
Earnings Per Share Guidance for the Year Ending December 31, 2008

                                                             2008
                                                         -------------

"Adjusted" earnings per share guidance                   $4.00 -$4.30

Known adjustments to arrive at GAAP earnings:
 Amortization of acquired intangible assets, product
  technology rights                                  (a)        (0.17)
 Stock option expense                                (b) (0.06)-(0.08)
 Restructuring costs                                 (c) (0.02)-(0.05)
 Amortization of acquired intangible assets, R&D
  technology rights                                  (d)        (0.04)
 Merger-related expenses                             (e)            -
                                                         -------------

GAAP earnings per share guidance                         $3.66 -$4.01
                                                         -------------

(a) To exclude the ongoing, non-cash amortization of acquired product
     technology rights, primarily ENBREL, related to the Immunex
     acquisition.

(b) To exclude stock option expense associated with SFAS No. 123R.

(c) To exclude restructuring related costs.

(d) To exclude the ongoing, non-cash amortization of the R&D
     technology intangible assets acquired with the Abgenix and Avidia
     acquisitions.

(e) To exclude merger related expenses in connection with our
     acquisition of the remaining 51 percent ownership interest of
     Dompe Biotec, S.p.A. As the final amount of such expenses has not
     been determined, no adjustment is reflected above.

SOURCE: Amgen

Amgen, Thousand Oaks
David Polk, 805-447-4613 (media)
Arvind Sood, 805-447-1060 (investors)