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Amgen's Fourth Quarter 2005 Adjusted Earnings Per Share Increased 29 Percent to 75 Cents; Full Year 2005 Adjusted Earnings Per Share Increased 33 Percent to $3.20

THOUSAND OAKS, Calif.--(BUSINESS WIRE)--Jan. 26, 2006--Amgen (NASDAQ:AMGN):

  • Fourth Quarter 2005 GAAP Earnings Per Share Increased to 66 Cents from 53 Cents; Full Year 2005 GAAP Earnings Per Share of $2.93
  • 2006 Total Revenue Expected to be in the Range of $13.9 to $14.4 Billion
  • 2006 Adjusted Earnings Per Share Expected to be In the Range of $3.55 to $3.70
  • Adjusted R&D Investment Expected to Grow 30 to 40 Percent in 2006

Amgen (NASDAQ:AMGN) reported adjusted earnings per share (EPS) of 75 cents for the fourth quarter of 2005, an increase of 29 percent compared to 58 cents during the fourth quarter of 2004. Adjusted net income rose 24 percent to $928 million compared to $749 million in the fourth quarter of 2004. Full year 2005 adjusted EPS were $3.20 versus $2.40 in 2004, a 33 percent increase. Full year 2005 adjusted net income was $4.0 billion versus $3.1 billion in 2004, a 28 percent increase.

Total revenue increased 12 percent during the fourth quarter of 2005 to $3.3 billion and 18 percent for the full year to $12.4 billion.

Adjusted EPS and adjusted net income for the three months and full years ended December 31, 2005 and 2004 exclude certain expenses related to the acquisitions of Immunex Corporation (Immunex) Tularik Inc. (Tularik) and certain other items. These expenses and other items are itemized on the reconciliation tables below.

On a reported basis and calculated in accordance with United States (U.S.) Generally Accepted Accounting Principles (GAAP), Amgen's EPS increased to 66 cents in the fourth quarter of 2005 from 53 cents in the same quarter last year. Net income was $824 million in the fourth quarter of 2005 versus $689 million in the fourth quarter of 2004. For the full year 2005, Amgen's reported EPS increased 62 percent to $2.93 from $1.81 in 2004. Full year 2005 net income was $3.7 billion versus $2.4 billion in 2004, an increase of 55 percent. Full year 2004 GAAP results were impacted by the acquisition of Tularik, which included a $554 million charge related to acquired in-process research and development.

"2005 was another strong year for Amgen," said Kevin Sharer, Amgen's chairman and chief executive officer. "In addition to delivering financially, we achieved four major regulatory milestones and added six new molecules to our pipeline. We made significant progress in advancing our late stage pipeline. Also during the fourth quarter, we received positive data from a pivotal trial with panitumumab, which could potentially advance the treatment of colorectal cancer. This contributed to our strategic decision to acquire Abgenix," concluded Sharer.

Product Sales Performance

During the fourth quarter, total product sales increased 14 percent to $3.2 billion from $2.8 billion in the fourth quarter of 2004. Sales in the U.S. totaled $2.6 billion, an increase of 13 percent versus the same quarter in 2004. International sales totaled $543 million versus $465 million during the comparable period in 2004. Changes in foreign exchange negatively impacted fourth quarter 2005 international sales by approximately $22 million. For the full year, total product sales were $12.0 billion in 2005 versus $10.0 billion in 2004, a 20 percent increase. Changes in foreign exchange added approximately $46 million to international sales for the full year 2005.

Worldwide sales of Aranesp(R) (darbepoetin alfa) increased 24 percent to $873 million in the fourth quarter of 2005 versus $705 million during the fourth quarter of 2004. This growth was principally driven by demand. U.S. Aranesp sales were $579 million versus $449 million in the prior year, with share gains and greater penetration in all major settings driving growth. International Aranesp sales were $294 million versus $256 million in the same quarter last year. Changes in foreign exchange negatively impacted fourth quarter 2005 sales by approximately $15 million. For the full year 2005, worldwide Aranesp sales were $3.3 billion versus $2.5 billion for 2004, an increase of 32 percent over the prior year's sales, driven by share gains and market growth.

Sales of EPOGEN(R) (Epoetin alfa) during the fourth quarter were $626 million versus $697 million in the comparable period of 2004, a decrease of 10 percent. For the full year 2005, EPOGEN sales were $2.5 billion versus $2.6 billion for 2004, a decrease of six percent. Both the quarter and full year decreases reflect lower demand, unfavorable changes in wholesaler inventory levels and unfavorable revised estimates of dialysis demand (primarily spillover) for prior quarters. Demand was affected by conversion to Aranesp in the hospital dialysis setting and reflects higher sales incentives. This conversion to Aranesp is expected to stabilize by mid-2006. Demand for Epogen in the freestanding dialysis clinics remains consistent with patient population growth of 3-4 percent. Spillover is a result of the Company's contractual relationship with Johnson & Johnson. (Please refer to the Company's 2004 Form 10-K for a more detailed discussion of this relationship and a description of spillover). Epogen is expected to resume modest growth in 2006.

Combined worldwide sales of Neulasta(R) (pegfilgrastim) and NEUPOGEN(R) (Filgrastim), were $928 million in the fourth quarter of 2005 versus $778 million for the fourth quarter of 2004, an increase of 19 percent. Combined sales growth for Neulasta and NEUPOGEN was primarily driven by increased demand for Neulasta, which benefited from recently updated National Comprehensive Cancer Network (NCCN) guidelines recommending earlier use.

Combined sales of Neulasta and NEUPOGEN in the United States were $729 million in the fourth quarter of 2005 versus $598 million in the fourth quarter of 2004, an increase of 22 percent. Combined international sales increased 11 percent to $199 million in the fourth quarter of 2005 versus $180 million over the same quarter in the prior year. Changes in foreign exchange negatively impacted fourth quarter 2005 combined international sales by approximately $8 million. For the full year 2005, combined worldwide sales of Neulasta and NEUPOGEN were $3.5 billion versus $2.9 billion for the full year 2004, an increase of 20 percent. Neulasta sales in particular, benefited from a label extension based on new clinical data demonstrating the value of first cycle use in moderate risk chemotherapy regimens.

Sales of Enbrel(R) (etanercept) increased 19 percent during the fourth quarter to $674 million versus $567 million during the same period in 2004. For the full year 2005, ENBREL sales increased 35 percent to $2.6 billion versus $1.9 billion in 2004. Strong demand drove sales growth reflecting growth in both rheumatology and dermatology. ENBREL continues to maintain a leading position in the dermatology and rheumatology biologic marketplaces.

Operating Expense Analysis on an Adjusted Basis:

  • Cost of sales increased to $511 million in the fourth quarter of 2005 from $476 million during the fourth quarter of 2004. For the full year 2005, cost of sales totaled $2.0 billion versus $1.7 billion in 2004. Increases for the fourth quarter and full year were primarily driven by higher sales volumes.
  • Research and development (R&D) expenses totaled $658 million during the fourth quarter versus $608 million in the fourth quarter of 2004. For the full year 2005, R&D expenses were $2.3 billion compared to $2.0 billion in 2004. Fourth quarter and full year increases were primarily driven by staff-related expenses and key clinical trials, including the large-scale Phase 3 trials for denosumab, Amgen's investigational therapy for bone loss. Full year staff-related expenses were also impacted by the acquisition of Tularik.
  • Selling, general and administrative (SG&A) expenses were $913 million in the fourth quarter versus $813 million for the same quarter of the prior year. For full year 2005, SG&A expenses totaled $2.8 billion compared to $2.5 billion in 2004. Increases for the fourth quarter and full year are a result of a higher level of profit sharing with Wyeth related to ENBREL sales growth. In addition, increases for the fourth quarter were also impacted by higher spending to support the Company's key products.

Stock repurchases for the fourth quarter 2005 totaled $1.2 billion representing 14.8 million shares. Stock repurchases for the full year 2005 were $4.4 billion representing approximately 63.2 million shares. In December 2005, the Company's board of directors authorized a new stock repurchase program of $5 billion. The Company currently has $1.5 billion remaining under its previous stock repurchase program.

In the fourth quarter of 2005, the Company repatriated approximately $500 million of foreign earnings pursuant to the American Jobs Creation Act of 2004. This was the maximum the Company could repatriate under the law, and had the effect of increasing GAAP tax expense by $43 million. The repatriation had no impact on the Company's adjusted tax rate.

Capital expenditures for full year 2005 were approximately $900 million versus $1.3 billion in 2004. The Company expects capital expenditures to exceed $1 billion annually over the next few years, as it invests in new manufacturing facilities and expands R&D operations.

The Company's cash and marketable securities were $5.3 billion at the end of 2005.

The company recently received FTC clearance for its proposed acquisition of Abgenix, Inc. (Abgenix), and closing is expected by late March/early April 2006.

2006 Guidance

The Company expects total revenue for 2006 to be in the range of $13.9 to $14.4 billion. The Company also expects adjusted R&D expense to increase by 30 to 40 percent, primarily due to an expected significant increase in clinical studies in 2006. Amgen initiated several large, late-stage clinical trials in 2005 that will continue in 2006, as well as additional trials that will begin enrollment in 2006. These include trials in denosumab in osteoporosis and metastatic bone disease, panitumumab and AMG 706 in several oncology indications, and landmark morbidity/mortality studies with Aranesp in patients with chronic kidney disease (CKD) and heart failure.

Amgen expects 2006 adjusted EPS in the range of $3.55 to $3.70. This guidance does not include the impact of stock option compensation expense, the dilutive impact of the proposed Abgenix acquisition, and certain expenses related to the acquisitions of Immunex and Tularik as well as the proposed acquisition of Abgenix. Amgen expects the impact of stock option compensation expense to be in the range of $0.12 - $0.14 in 2006 compared to $ 0.19 for 2005. As the Company announced previously, the Abgenix acquisition could result in dilution of $0.05 to $0.10 for 2006 and 2007, and is expected to be accretive thereafter, assuming commercial success of panitumumab.

Fourth Quarter Product and Pipeline Highlights

The Company also highlighted research and development matters, including a pipeline overview, selected late-stage clinical programs (Aranesp, AMG 706, panitumumab, AMG 531, and denosumab), new clinical programs, and R&D investment strategy.

Aranesp: New Phase 3 data showing the potential benefits of Aranesp dosed every three weeks for chemotherapy-induced anemia were presented at the American Society of Hematology (ASH). The study revealed that Aranesp increased and maintained patient hemoglobin levels to the target level of greater than or equal to 11 grams per deciliter (g/dL) and reduced the need for red blood cell transfusions by almost half compared to placebo. A separate study demonstrated that 85 percent of chronic kidney disease patients not on dialysis who received Aranesp administered once monthly maintained hemoglobin levels of greater than or equal to 11 g/dL. These patients were previously receiving Aranesp dosed every other week.

Updated interim Phase 2 data for Aranesp in myelodysplastic syndrome was also presented at ASH suggesting a major response in anemic patients administered 500 mcg of Aranesp every three weeks.

Enbrel: New results for ENBREL were announced at the American College of Rheumatology Annual Scientific Meeting (ACR) showing that in a long-term blinded study in patients with rheumatoid arthritis, more than three quarters of patients treated with ENBREL plus methotrexate combination therapy experienced no progression of joint damage at three years.

Kepivance (palifermin): The Company announced that Kepivance received regulatory approval in the European Union to decrease the incidence, duration and severity of oral mucositis (mouth sores) in patients with hematologic (blood) cancers undergoing myeloablative therapy associated with a high incidence of severe oral mucositis and requiring autologous blood and bone marrow transplant.

Panitumumab: Top line Phase 3 trial results were announced during the quarter, showing that panitumumab met its primary endpoint of improving progression-free survival in patients with metastatic colorectal cancer who had failed standard chemotherapy. In this randomized trial involving 463 patients, those who received panitumumab every two weeks showed a 46 percent decrease in tumor progression rate versus those who received best supportive care alone (p less than 0.000000001). Based on this data, Amgen and Abgenix initiated a biologics license application (BLA) with the Food and Drug Administration (FDA). In addition, Amgen announced the acquisition of Abgenix, which would provide the Company with full ownership of panitumumab.

Denosumab (formerly known as AMG 162): Phase 2 trial results for denosumab in osteoporosis were presented at ACR. The data showed that twice-yearly subcutaneous injections of denosumab (60 mg) increased bone mineral density in the lumbar spine, total hip, distal 1/3 radius and total body compared to placebo at 24 months. In addition, topline Phase 2 results for denosumab in rheumatoid arthritis patients was disclosed at the company's analyst meeting. The results indicated that when compared to placebo, denosumab decreased the proportion of patients whose joint erosion progressed as measured by MRI. Denosumab may also inhibit damage to cartilage as measured by CTX-II.

AMG 531: Interim long-term follow-up data were shown at ASH demonstrating that AMG 531 increases platelets in patients with immune thrombocytopenic purpura. Overall, 85 percent of patients in the study (29 of 34) achieved a platelet response, defined as doubling of the baseline platelet count and at least 50,000 platelets per microliter of blood.

For more product information or the full prescribing information, please refer to the Amgen Web site at www.amgen.com.

Forward-Looking Statements

This news release contains forward-looking statements that involve significant risks and uncertainties, including those discussed below and others that can be found in our Form 10-K for the year ended December 31, 2004, and in our periodic reports on Form 10-Q and Form 8-K. Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise.

No forward-looking statement can be guaranteed and actual results may differ materially from those we project. The Company's results may be affected by our ability to successfully market both new and existing products domestically and internationally, sales growth of recently launched products, difficulties or delays in manufacturing our products, and regulatory developments (domestic or foreign) involving current and future products and manufacturing facilities. In addition, sales of our products are affected by reimbursement policies imposed by first party payors, including governments, private insurance plans and managed care providers, and may be affected by domestic and international trends toward managed care and healthcare cost containment as well as possible US legislation affecting pharmaceutical pricing and reimbursement. Government regulations and reimbursement policies may affect the development, usage and pricing of our products. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. We, or others could identify side effects or manufacturing problems with our products after they are on the market. In addition, we compete with other companies with respect to some of our marketed products as well as for the discovery and development of new products. Discovery or identification of new product candidates cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate will be successful and become a commercial product. In addition, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors. Further, some raw materials, medical devices, and component parts for our products are supplied by sole third party suppliers.

About Amgen

Amgen discovers, develops and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science's promise by bringing safe and effective medicines from lab, to manufacturing plant, to patient. Amgen therapeutics have changed the practice of medicine, helping millions of people around the world in the fight against cancer, kidney disease, rheumatoid arthritis, and other serious illnesses. With a broad and deep pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people's lives. To learn more about our pioneering science and our vital medicines, visit www.amgen.com.

EDITOR'S NOTE: An electronic version of this news release may be accessed via our Web site at www.amgen.com. Journalists and media representatives may sign up to receive all news releases electronically at time of announcement by filling out a short form in the Media section of the Web site.


Amgen Inc.
Condensed Consolidated Statements of Operations and
Reconciliation of GAAP Earnings to "Adjusted" Earnings
(In millions, except per share data)
(Unaudited)

                                              Three Months Ended
                                              December 31, 2005
                                        ------------------------------
                                         GAAP   Adjustments "Adjusted"
                                        ------- ----------- ----------
Revenues:
 Product sales                          $3,168      $-         $3,168
 Other revenues                            103       -            103
                                        ------- -------     ----------
  Total revenues                         3,271       -          3,271

Operating expenses:
 Cost of sales (excludes amortization
  of acquired intangible assets
  presented below)                         511       -            511
 Research and development                  661      (3)(1)        658
 Selling, general and administrative       911       2 (2)        913
 Amortization of intangible assets          87     (87)(3)          -
                                        ------- -------     ----------
  Total operating expenses               2,170     (88)         2,082

Operating income                         1,101      88          1,189

Interest and other income, net              10       -             10
                                        ------- -------     ----------

Income before income taxes               1,111      88          1,199

Provision for income taxes                 287     (43)(4)        271
                                                    27 (11)
                                        ------- -------     ----------

Net income                                $824    $104           $928
                                        ======= =======     ==========

Earnings per share:
 Basic                                   $0.67                  $0.76
 Diluted(12)                             $0.66                  $0.75

Shares used in calculation of earnings
 per share:
 Basic                                   1,229                  1,229
 Diluted(12)                             1,243                  1,243


                                              Three Months Ended
                                              December 31, 2004
                                        ------------------------------
                                         GAAP   Adjustments "Adjusted"
                                        ------- ----------- ----------
Revenues:
 Product sales                          $2,778      $-         $2,778
 Other revenues                            131       -            131
                                        ------- -------     ----------
  Total revenues                         2,909       -          2,909

Operating expenses:
 Cost of sales (excludes amortization
  of acquired intangible assets
  presented below)                         476       -            476
 Research and development                  617      (9)(1)        608
 Selling, general and administrative       816      (3)(1)        813
 Amortization of intangible assets          81     (81)(3)          -
                                        ------- -------     ----------
  Total operating expenses               1,990     (93)         1,897

Operating income                           919      93          1,012

Interest and other income, net               1       -              1
                                        ------- -------     ----------

Income before income taxes                 920      93          1,013

Provision for income taxes                 231      33 (11)       264

                                        ------- -------     ----------

Net income                                $689     $60           $749
                                        ======= =======     ==========

Earnings per share:
 Basic                                   $0.55                  $0.59
 Diluted(12)                             $0.53                  $0.58

Shares used in calculation of earnings
 per share:
 Basic                                   1,263                  1,263
 Diluted(12)                             1,310                  1,310

(1)-(12) See explanatory notes


Amgen Inc.
Condensed Consolidated Statements of Operations and
Reconciliation of GAAP Earnings to "Adjusted" Earnings
(In millions, except per share data)
(Unaudited)

                                                 Year Ended
                                              December 31, 2005
                                       -------------------------------
                                         GAAP   Adjustments "Adjusted"
                                       -------------------- ----------
Revenues:
 Product sales                         $12,022      $-        $12,022
 Other revenues                            408       -            408
                                       -------- -------     ----------
  Total revenues                        12,430       -         12,430

Operating expenses:
 Cost of sales (excludes amortization
  of acquired intangible assets
  presented below)                       2,082     (47)(5)      2,035
 Research and development                2,314     (12)(1)      2,302

 Selling, general and administrative     2,790       2 (2)      2,792


 Write-off of acquired in-process R&D        -       -              -
 Amortization of intangible assets         347    (347)(3)          -
 Legal settlements                          49     (49)(6)          -
                                       -------- -------     ----------
  Total operating expenses               7,582    (453)         7,129

Operating income                         4,848     453          5,301

Interest and other income, net              20     (20)(7)         20
                                                    20 (8)
                                       -------- -------     ----------

Income before income taxes               4,868     453          5,321

Provision for income taxes               1,194     (43)(4)      1,298
                                                   147 (11)
                                       -------- -------     ----------

Net income                              $3,674    $349         $4,023
                                       ======== =======     ==========

Earnings per share:
 Basic                                   $2.97                  $3.25
 Diluted(12)                             $2.93                  $3.20

Shares used in calculation of earnings
 per share:
 Basic                                   1,236                  1,236
 Diluted(12)                             1,258                  1,258


                                                 Year Ended
                                              December 31, 2004
                                       -------------------------------
                                         GAAP   Adjustments "Adjusted"
                                       -------------------- ----------
Revenues:
 Product sales                          $9,977      $-         $9,977
 Other revenues                            573       -            573
                                       -------- -------     ----------
  Total revenues                        10,550       -         10,550

Operating expenses:
 Cost of sales (excludes amortization
  of acquired intangible assets
  presented below)                       1,731      (2)(9)      1,729
 Research and development                2,028     (16)(1)      1,996
                                                   (16)(9)
 Selling, general and administrative     2,556     (11)(1)      2,548
                                                    (8)(9)
                                                    11 (2)
 Write-off of acquired in-process R&D      554    (554)(10)         -
 Amortization of intangible assets         333    (333)(3)          -
 Legal settlements                           -       -              -
                                       -------- -------     ----------
  Total operating expenses               7,202    (929)         6,273

Operating income                         3,348     929          4,277

Interest and other income, net              47       -             47

                                       -------- -------     ----------

Income before income taxes               3,395     929          4,324

Provision for income taxes               1,032     144 (11)     1,176

                                       -------- -------     ----------

Net income                              $2,363    $785         $3,148
                                       ======== =======     ==========

Earnings per share:
 Basic                                   $1.86                  $2.48
 Diluted(12)                             $1.81                  $2.40

Shares used in calculation of earnings
 per share:
 Basic                                   1,271                  1,271
 Diluted(12)                             1,320                  1,320


(1)-(12) See explanatory notes


Amgen Inc.
Notes to Reconciliation of GAAP Earnings to "Adjusted" Earnings
(In millions, except per share data)
(Unaudited)

(1)  To exclude the incremental compensation provided to certain
     Tularik Inc. ("Tularik") employees principally related to
     non-cash compensation expense associated with stock options
     assumed in connection with the acquisition and amounts payable
     under the Tularik short-term retention plan. The total estimated
     remaining costs of such incremental compensation is approximately
     $15 million, pre-tax.

(2)  To exclude the impact to the Company of its share of the
     third-party reimbursements received by Kirin-Amgen, Inc. related
     to the Genentech, Inc. ("Genentech") legal settlement in August
     2003.

(3)  To exclude the ongoing, non-cash amortization of acquired
     intangible assets, primarily Enbrel(R), related to the Immunex
     Corporation ("Immunex") acquisition. The annual non-cash charge
     is currently estimated to be approximately $347 million, pre-tax.

(4)  To exclude the tax liability incurred as a result of
     repatriating certain foreign earnings under the American Jobs
     Creation Act of 2004.

(5)  To exclude the impact of writing off the cost of a
     semi-completed manufacturing asset that will not be used due to a
     change in manufacturing strategy.

(6)  To exclude the impact of legal settlements incurred, net of
     amounts previously accrued, primarily related to settling a
     patent legal proceeding.

(7)  To exclude the net gain realized on the termination of a
     manufacturing agreement with Genentech for the production of
     ENBREL at Genentech's manufacturing facility in San Francisco,
     California.

(8)  To exclude the pro rata portion of the debt issuance costs
     that were immediately charged to interest expense, as a result of
     certain holders of the convertible notes exercising their March
     1, 2005 put option and the related convertible notes being repaid
     in cash.

(9)  To exclude the incremental compensation payable to certain
     Immunex employees principally under the Immunex short-term
     retention plan. All amounts have been incurred under this plan.

(10) To exclude the non-cash expense associated with writing off
     the acquired in-process research and development related to the
     Tularik acquisition.

(11) To reflect the tax effect of the above adjustments, except
     for the tax liability incurred as a result of repatriating
     certain foreign earnings (see (4) above), the write-off of the
     cost of a semi-completed manufacturing asset (see (5) above), and
     the write-off of acquired in-process R&D (see (10) above).

(12) The following table presents the computations for GAAP and
     "Adjusted" diluted earnings per share (EPS) computed under the
     treasury stock and the "if-converted" methods:

                            Three Months Ended      Three Months Ended
                             December 31, 2005      December 31, 2004
                           ---------------------    ------------------
                            GAAP      "Adjusted"     GAAP   "Adjusted"
                           ---------- ----------    ------------------
 Income (Numerator):
  Net income for basic EPS   $824          $928       $689       $749
  Adjustment for interest
   expense on convertible
   notes, net of tax            - (A)         - (A)      6          6
                           -------    ----------    ------- ----------
  Net income for diluted
   EPS, after assumed
   conversion of
   convertible notes         $824          $928       $695       $755
                           =======    ==========    ======= ==========

 Shares (Denominator):
  Weighted-average shares
   for basic EPS            1,229         1,229      1,263      1,263
  Effect of dilutive
   securities                  14            14         12         12
  Effect of convertible
   notes, after assumed
   conversion                   - (A)         - (A)     35         35
                           -------    ----------    ------- ----------
  Weighted-average shares
   for diluted EPS          1,243         1,243      1,310      1,310
                           =======    ==========    ======= ==========

 Diluted earnings per
  share                     $0.66         $0.75      $0.53      $0.58
                           =======    ==========    ======= ==========


                                 Year Ended             Year Ended
                             December 31, 2005      December 31, 2004
                           ---------------------    ------------------
                            GAAP      "Adjusted"     GAAP   "Adjusted"
                           ---------- ----------    ------------------
 Income (Numerator):
  Net income for basic EPS $3,674        $4,023     $2,363     $3,148
  Adjustment for interest
   expense on convertible
   notes, net of tax            6 (A)         6 (A)     21         21
                           -------    ----------    ------- ----------
  Net income for diluted
   EPS, after assumed
   conversion of
   convertible notes       $3,680        $4,029     $2,384     $3,169
                           =======    ==========    ======= ==========

 Shares (Denominator):
  Weighted-average shares
   for basic EPS            1,236         1,236      1,271      1,271
  Effect of dilutive
   securities                  12            12         14         14
  Effect of convertible
   notes, after assumed
   conversion                  10 (A)        10 (A)     35         35
                           -------    ----------    ------- ----------
  Weighted-average shares
   for diluted EPS          1,258         1,258      1,320      1,320
                           =======    ==========    ======= ==========

 Diluted earnings per
  share                     $2.93         $3.20      $1.81      $2.40
                           =======    ==========    ======= ==========

(A) On May 6, 2005 and August 17, 2005, in connection with an
    exchange offer, we modified the terms of approximately 99 percent
    of our convertible notes then outstanding (the "Modified
    Convertible Notes"). As a result of certain of these
    modifications, if converted, the Modified Convertible Notes would
    be settled in 1) cash equal to the lesser of the accreted value of
    the Modified Convertible Notes at the conversion date or the
    conversion value, as defined, and 2) shares of common stock, if
    any, to the extent the conversion value exceeds the accreted
    value. Accordingly, the Modified Convertible Notes do not impact
    diluted earnings per share under the "if-converted" method but
    rather, they impact diluted earnings per share under the treasury
    stock method, and only to the extent that the conversion value
    exceeds the accreted value during any reporting period, requiring
    such difference, if any, to be potentially settled in shares of
    common stock.


Amgen Inc.
Product Sales Detail by Product and Geographic Region
(In millions)
(Unaudited)

                                       Three Months         Year
                                           Ended           Ended
                                       December 31,     December 31,
                                      --------------- ----------------
                                       2005    2004    2005     2004
                                      --------------- ----------------

Aranesp(R) - U.S.                       $579    $449   $2,104  $1,533

Aranesp(R) - International               294     256    1,169     940

EPOGEN(R) - U.S.                         626     697    2,455   2,601

Neulasta(R) - U.S.                       519     394    1,900   1,476

NEUPOGEN(R) - U.S.                       210     204      805     778

Neulasta(R) - International              104      75      388     264

NEUPOGEN(R) - International               95     105      411     397

Enbrel(R) - U.S.                         645     545    2,470   1,827

Enbrel(R) - International                 29      22      103      73

Sensipar(R) - U.S.                        37      18      122      36

Sensipar(R) - International               14       1       35       1

Other product sales - U.S.                 9       6       36      28

Other product sales - International        7       6       24      23
                                      --------------- ----------------

 Total product sales                  $3,168  $2,778  $12,022  $9,977
                                      =============== ================


U.S.                                  $2,625  $2,313   $9,892  $8,279

International                            543     465    2,130   1,698
                                      --------------- ----------------

                                      $3,168  $2,778  $12,022  $9,977
                                      =============== ================


Amgen Inc.
Condensed Consolidated Balance Sheets - GAAP
(In millions)
(Unaudited)

                                       December 31,    December 31,
                                           2005           2004
                                       -------------   ------------
Assets
Current assets:
 Cash and marketable securities              $5,255         $5,808
 Trade receivables, net                       1,769          1,461
 Inventories                                  1,258            888
 Other current assets                           953          1,013
                                       -------------   ------------
      Total current assets                    9,235          9,170
Property, plant, and equipment, net           5,038          4,712
Intangible assets, net                        3,742          4,033
Goodwill                                     10,495         10,525
Other assets                                    787            781
                                       -------------   ------------
      Total assets                          $29,297        $29,221
                                       =============   ============

Liabilities and Stockholders' Equity
Current liabilities:
 Accounts payable and accrued
  liabilities                                $3,595         $2,984
 Convertible notes                            1,759 (2)      1,173 (1)
                                       -------------   ------------
      Total current liabilities               5,354          4,157
Deferred tax liabilities                      1,163          1,294
Convertible notes                                 -          1,739 (2)
Other long-term debt                          2,198          2,198
Other non-current liabilities                   131            128
Stockholders' equity                         20,451         19,705
                                       -------------   ------------
      Total liabilities and
       stockholders' equity                 $29,297        $29,221
                                       =============   ============

Shares outstanding                            1,224          1,260

(1) On March 2, 2005, as a result of certain holders of the
    Convertible notes exercising their March 1, 2005 put option, the
    Company repurchased $1,175 million, or approximately 40 percent,
    of the outstanding Convertible notes at their then-accreted value
    for cash. Accordingly, the Convertible notes repurchased were
    classified as current liabilities at December 31, 2004.

(2) Holders of the remaining outstanding Convertible notes may
    require the Company to purchase all or a portion of the notes on
    specific dates as early as March 1, 2006 at the original issuance
    price plus accrued original issue discount through the purchase
    date. Accordingly, as of December 31, 2005, the Convertible notes
    have been classified as current liabilities.


Amgen Inc.
Reconciliation of "Adjusted" Earnings Per Share Guidance to GAAP
Earnings Per Share Guidance for the Year Ended December 31, 2006

                                                             2006
                                                        --------------

"Adjusted" earnings per share guidance                  $3.55 - $3.70

Known adjustments to arrive at GAAP earnings:
 Amortization of acquired intangible assets(1)                  (0.18)
 Tularik merger related incremental compensation(2)             (0.01)
 Stock option compensation(3)                                       -
 Write-off of Abgenix acquired in-process R&D
  and other merger-related expenses(4)                              -
                                                        --------------

GAAP earnings per share guidance                        $3.36 - $3.51
                                                        --------------

    Note: The guidance for both "Adjusted" earnings per share and GAAP
    earnings per share does not include dilution of $0.05-$0.10 from
    the proposed acquisition of Abgenix, Inc. ("Abgenix")

(1) To exclude the ongoing, non-cash amortization of acquired
    intangible assets, primarily Enbrel(R), related to the Immunex
    acquisition. The total 2006 annual non-cash charge is currently
    estimated to be approximately $347 million, pre-tax.

(2) To exclude the incremental compensation provided to certain
    Tularik employees principally related to non-cash compensation
    expense associated with stock options assumed in connection with
    the acquisition and amounts payable under the Tularik short-term
    retention plan.

(3) To exclude the estimated stock option compensation expense
    associated with Amgen's adoption of Statement of Financial
    Accounting Standard No. 123R "Share-Based Payment" on January 1,
    2006. The total 2006 stock option compensation expense is
    currently estimated to be approximately $210-$250 million,
    pre-tax, or approximately $0.12-$0.14 dilution to GAAP earnings
    per share. As the final amount of such expense has not yet been
    determined, no adjustment is reflected above.

(4) In connection with the proposed acquisition of Abgenix, Amgen will
    incur a one-time expense associated with writing off acquired
    in-process research and development. In addition, Amgen will incur
    other merger-related expenses. As the final amount of such
    expenses has not yet been determined, no adjustment is reflected
    above.


Amgen Inc.
Reconciliation of "Adjusted" Research and Development Expense Guidance
to GAAP Research and Development Expense Guidance for the Year Ended
December 31, 2006
(In millions)

                                                            2006
                                                      ----------------
"Adjusted" research and development expense guidance  $2,993 - $3,223

Known adjustments to arrive at GAAP earnings:
   Tularik merger related expenses
    (acquired August 2004)                                         12
   Abgenix merger related expenses
    (proposed acquisition) (1)                                      -
   Stock option compensation (2)                                    -
                                                      ----------------

GAAP research and development expense guidance        $3,005 - $3,235
                                                      ----------------

        Note: The guidance for both "Adjusted" and GAAP research and
        development expense excludes a one-time expense associated
        with writing off acquired in-process research and development
        to be incurred in connection with the proposed acquisition of
        Abgenix. The amount of such expense has not yet been
        determined. For GAAP reporting purposes, charges relating to
        acquired in-process research and development are reported
        separately from research and development expense on the
        consolidated statements of operations.

    (1) In connection with the proposed acquisition of Abgenix, Amgen
        will incur research and development merger-related expenses.
        As the final amounts of such expenses have not yet been
        determined, no adjustment is reflected above.

    (2) In connection with Amgen's adoption of Statement of Financial
        Accounting Standard No. 123R "Share-Based Payment" on January
        1, 2006, Amgen will expense stock option compensation. As the
        final amount of such expense has not yet been determined, no
        adjustment is reflected above.

CONTACT: Amgen, Thousand Oaks
Mary Klem, 805/447-4587 (media)
Arvind Sood, 805/447-1060 (investors)

SOURCE: Amgen Inc.