SECURITIES AND EXCHANGE COMMISSION

                        WASHINGTON D.C. 20549

                              FORM 10-Q


(Mark One)
[ X ]  QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE 
       SECURITIES EXCHANGE ACT OF 1934

     For the quarterly period ended September 30, 1995

                                 OR

[   ]  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
       SECURITIES EXCHANGE ACT OF 1934


Commission file number 0-12477


                             AMGEN INC.
       (Exact name of registrant as specified in its charter)


          Delaware                                95-3540776
- -------------------------------         -----------------------------
(State or other jurisdiction of                (I.R.S. Employer
incorporation or organization)                Identification No.)


1840 Dehavilland Drive, Thousand Oaks, California     91320-1789
- ---------------------------------------------------------------------
    (Address of principal executive offices)          (Zip Code)


Registrant's telephone number, including area code:    (805) 447-1000

Indicate by  check mark  whether the  registrant  (1) has  filed  all
reports required to be filed by Section 13 or 15(d) of the Securities
Exchange Act of  1934 during the  preceding 12 months   (or for  such
shorter  period  that  the  registrant  was  required  to  file  such
reports), and (2) has  been subject to  such filing requirements  for
the past 90 days.                  Yes  X    No

     As of  September 30,  1995,  the registrant  had  265,998,635(A)
shares of Common Stock, $.0001 par value, outstanding.
- ---------------

(A)All share numbers have  been adjusted retroactively to  reflect a
   two-for-one split of the common stock  effected in the form  of a
   100 percent  stock dividend  distributed on  August  15, 1995  to
   stockholders of record on August 1, 1995.

                             AMGEN INC.

                                INDEX


                                                         Page No.

PART I    FINANCIAL INFORMATION

          Item 1. Financial Statements.......................3

            Condensed Consolidated Statements of
            Operations - three and nine months
            ended September 30, 1995 and 1994 ...............4

            Condensed Consolidated Balance Sheets -
            September 30, 1995 and December 31, 1994 ........5

            Condensed Consolidated Statements of
            Cash Flows - nine months
            ended September 30, 1995 and 1994 ...........6 - 7

            Notes to Condensed Consolidated Financial
            Statements ......................................8

          Item 2. Management's Discussion and Analysis
                  of Financial Condition and Results of
                  Operations................................13


PART II   OTHER INFORMATION

          Item 1.Legal Proceedings .........................18

          Item 6.Exhibits and Reports on Form 8-K ..........19

          Signatures........................................20

          Index to Exhibits.................................21


                   PART I - FINANCIAL INFORMATION


Item 1.   Financial Statements

     The information in  this report for  the three  and nine  months
ended September  30, 1995  and 1994,  is unaudited  but includes  all
adjustments (consisting  only  of normal  recurring  accruals)  which
Amgen Inc. ("Amgen" or the "Company") considers necessary for a  fair
presentation of the results of operations for those periods.

     The condensed financial statements should be read in conjunction
with  the  Company's  financial  statements  and  the  notes  thereto
contained in the Company's Annual Report on Form 10-K for the  fiscal
year ended December 31, 1994.

     Interim results are  not necessarily indicative  of results  for
the full fiscal year.

                             AMGEN INC.

           CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

                (In millions, except per share data)
                             (Unaudited)

                              Three Months Ended   Nine Months Ended
                                 September 30,       September 30,
                                 1995     1994      1995      1994
                               -------- --------  --------  --------
Revenues:                  
 Product sales ..............   $460.6   $401.7   $1,334.4  $1,136.0
 Corporate partner revenues .     23.8     16.9       65.1      49.7
 Royalty income .............      8.9      7.7       26.9      19.3
                                ------   ------   --------  --------
  Total revenues ............    493.3    426.3    1,426.4   1,205.0
                                ------   ------   --------  --------
Operating expenses:
 Cost of sales ..............     64.1     59.1      207.1     176.8
 Research and development ...    105.5     81.7      327.7     235.6
 Marketing and selling ......     69.1     61.9      197.8     174.7
 General and administrative .     37.6     31.9      106.8      90.4
 Loss of affiliates, net ....     15.2      9.8       41.2      25.6
                                ------   ------   --------  --------
  Total operating expenses ..    291.5    244.4      880.6     703.1
                                ------   ------   --------  --------
Operating Income.............    201.8    181.9      545.8     501.9
                                ------   ------   --------  --------
Other income (expense):
 Interest and other income ..     15.4      6.8       46.7      16.0
 Interest expense, net ......     (3.6)    (3.3)     (11.2)     (8.7)
                                ------   ------   --------  --------
  Total other income
   (expense) ................     11.8      3.5       35.5       7.3
                                ------   ------   --------  --------
Income before income taxes...    213.6    185.4      581.3     509.2

Provision for income taxes...     67.8     71.4      189.2     194.3
                                ------   ------   --------  --------
Net income...................   $145.8   $114.0   $  392.1  $  314.9
                                ======   ======   ========  ========

Earnings per share:
 Primary ....................    $0.52     $0.41      $1.40     $1.12
 Fully diluted ..............    $0.51     $0.41      $1.38     $1.12

Shares used in calculation of:
 Primary earnings per share .    281.8    278.5      280.2     280.0
 Fully diluted earnings per
  share .....................    283.2    279.1      283.8     281.9

                       See accompanying notes.

                             AMGEN INC.

                CONDENSED CONSOLIDATED BALANCE SHEETS

                (In millions, except per share data)
                             (Unaudited)


                                           September 30, December 31,
                                                1995        1994
                                            -----------  -----------
                               ASSETS
Current assets:
 Cash and cash equivalents ................  $  145.0      $  211.3
 Marketable securities ....................     846.7         485.4
 Trade receivables, net ...................     205.3         194.7
 Inventories ..............................      85.8          98.0
 Deferred tax assets, net .................      70.2          70.2
 Other current assets .....................      67.0          56.0
                                             --------      --------
   Total current assets ...................   1,420.0       1,115.6

Property, plant and equipment at cost, net      707.9         665.3
Investments in affiliated companies.......       76.4          82.3
Other assets..............................      143.9         130.9
                                             --------      --------
                                             $2,348.2      $1,994.1
                                             ========      ========

                 LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
 Accounts payable .........................  $   47.2      $   30.5
 Commercial paper .........................      99.5          99.7
 Other accrued liabilities ................     449.5         406.2
                                             --------      --------
   Total current liabilities ..............     596.2         536.4

Long-term debt............................      177.2         183.4

Contingencies

Stockholders' equity:
 Common stock, $.0001 par value; 750.0
  shares authorized; outstanding - 266.0
  shares in 1995 and 264.7 shares in 1994 .         -             -
 Additional paid-in capital ...............     827.6         719.3
 Retained earnings ........................     747.2         555.0
                                             --------      --------
   Total stockholders' equity .............   1,574.8       1,274.3
                                             --------      --------
                                             $2,348.2      $1,994.1
                                             ========      ========

                       See accompanying notes.

                             AMGEN INC.

           CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

                            (In millions)
                             (Unaudited)

                                            Nine Months Ended
                                               September 30,
                                             1995        1994
                                          ----------  ----------

   Cash flows from operating activities:
    Net income ..........................  $   392.1   $   314.9
    Depreciation and amortization .......       64.3        57.9
    Deferred income taxes ...............          -         3.0
    Loss of affiliates, net .............       41.2        25.6
    Cash provided by (used in):
      Trade receivables, net ............      (10.6)      (21.8)
      Inventories .......................       12.2       (12.5)
      Other current assets ..............      (11.0)       (3.8)
      Accounts payable ..................       16.7        (1.2)
      Accrued liabilities ...............       43.3       (14.4)
                                           ---------   ---------
       Net cash provided by operating
        activities ......................      548.2       347.7
                                           ---------   ---------

   Cash flows from investing activities:
    Purchases of property, plant and
      equipment .........................     (106.8)      (93.7)
    Proceeds from maturities of
      marketable securities .............       79.8        82.7
    Proceeds from sales of marketable
      securities ........................      894.1     1,174.9
    Purchases of marketable securities ..   (1,335.2)   (1,115.0)
    Increase in investments in
      affiliated companies ..............       (0.4)      (18.8)
    Increase in other assets ............      (13.0)       (9.6)
                                           ---------   ---------
       Net cash (used in) provided by
        investing activities ............  $  (481.5)  $    20.5
                                           ---------   ---------


                       See accompanying notes.
                      (Continued on next page)

                             AMGEN INC.

     CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Continued)

                            (In millions)
                             (Unaudited)

                                             Nine Months Ended
                                               September 30,
                                              1995        1994
                                          ----------  ----------

   Cash flows from financing activities:
    Decrease in commercial paper ........  $    (0.2)  $   (10.2)
    Proceeds from issuance of long-term
      debt ..............................          -        12.5
    Repayment of long-term debt .........       (6.2)       (9.3)
    Net proceeds from issuance of common
      stock upon the exercise of stock
      options ...........................       84.6        30.7
    Tax benefit related to stock options        23.6        14.5
    Net proceeds from issuance of common
      stock upon the exercise of warrants          -        15.3
    Repurchases of common stock .........     (199.9)     (226.0)
    Other ...............................      (34.9)      (22.7)
                                           ---------   ---------
       Net cash used in financing
        activities ......................     (133.0)     (195.2)
                                           ---------   ---------

   (Decrease) increase in cash and cash        
    equivalents .........................      (66.3)      173.0

   Cash and cash equivalents at
    beginning of period .................      211.3       128.5
                                           ---------   ---------
   Cash and cash equivalents at end of
    period ..............................  $   145.0   $   301.5
                                           =========   =========

                       See accompanying notes.

                             AMGEN INC.
        NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
                         September 30, 1995


1.   Summary of significant accounting policies

  Business

     Amgen Inc. ("Amgen" or the "Company") is a global  biotechnology
company that develops,  manufactures and  markets human  therapeutics
based on advanced cellular and molecular biology.

  Principles of consolidation

     The consolidated financial  statements include  the accounts  of
the Company and its wholly owned  subsidiaries as well as  affiliated
companies for which the Company has a controlling financial  interest
and exercises  control over  their operations  ("majority  controlled
affiliates").  All  material intercompany  transactions and  balances
have been  eliminated in  consolidation.   Investments in  affiliated
companies which  are 50%  owned and/or  where the  Company  exercises
significant influence  over operations  are accounted  for using  the
equity method.  All other equity investments are accounted for  under
the cost  method.   The caption  "Loss of  affiliates, net"  includes
Amgen's equity in the operating  results of affiliated companies  and
the minority interest others hold in the operating results of Amgen's
majority controlled affiliates.

  Inventories

     Inventories are stated at the lower of cost or market.  Cost  is
determined in  a manner  which approximates  the first-in,  first-out
(FIFO) method.  Inventories are shown net of applicable reserves  and
allowances.  Inventories consist of the following (in millions):

                                September 30,  December 31,
                                     1995          1994
                                    ------        ------
        Raw materials .........     $10.5          $11.0
        Work in process .......      43.8           54.0
        Finished goods ........      31.5           33.0
                                    -----          -----
                                    $85.8          $98.0
                                    =====          =====

  Product sales

     Product sales consist of two products, EPOGEN(R) (Epoetin  alfa)
and NEUPOGEN(R) (Filgrastim).

     Quarterly NEUPOGEN(R)  sales  volume  in the  United  States  is
influenced by  a  number  of  factors  including  underlying  demand,
seasonality of  cancer  chemotherapy  administration  and  wholesaler
inventory management practices.  Wholesaler inventory reductions tend

to reduce domestic NEUPOGEN(R) sales in the first quarter each  year.
NEUPOGEN(R) sales in  the European  Union ("EU")  have experienced  a
decline in the third quarter in prior years due to seasonality.

       As  a  result  of  an   agreement  between  Amgen  and   Ortho
Pharmaceutical  Corporation,  a  subsidiary  of  Johnson  &   Johnson
("Johnson &  Johnson") covering  the U.S.  market for  the  Company's
Epoetin alfa product, Amgen does not recognize product sales it makes
into the contractual market of Johnson  & Johnson and does  recognize
the product sales made by Johnson & Johnson into Amgen's  contractual
market.  These  sales amounts, and  adjustments thereto, are  derived
from third-party data on shipments to end users and their usage  (see
Note 4, "Contingencies - Johnson & Johnson arbitrations").

  Income taxes

     Income taxes are accounted for  in accordance with Statement  of
Financial Accounting Standards ("SFAS") No. 109 (Note 3).

  Earnings per share

     Earnings per share are computed in accordance with the  treasury
stock method.  Primary and fully diluted earnings per share are based
upon the weighted average number of common shares and dilutive common
stock equivalents during the period  in which they were  outstanding.
Common  stock  equivalents  include  outstanding  options  under  the
Company's stock option plans and warrants  to purchase shares of  the
Company's common stock.  The warrants expired on June 30, 1994.

  Basis of presentation

     The financial information  for the three  and nine months  ended
September 30, 1995 and 1994 is unaudited but includes all adjustments
(consisting only  of normal  recurring  accruals) which  the  Company
considers necessary  for  a  fair  presentation  of  the  results  of
operations for these  periods.  Interim  results are not  necessarily
indicative of results for the full fiscal year.

  Reclassification

     Certain prior period amounts  have been reclassified to  conform
to the current period presentation.


2.   Debt

     As of September 30, 1995, $99.5 million of commercial paper  was
outstanding.   These borrowings  generally  had maturities  of  three
months or less and had effective interest rates averaging 5.9%.

     In June 1995, the Company replaced its existing unsecured credit
facility with a new unsecured credit facility (the "credit facility").
The credit  facility includes a commitment  expiring on June 23, 2000
for  up  to $150.0  million  of  borrowings under a revolving line of
credit (the "revolving line commitment") and a commitment expiring on

December 5, 1997 for up to an additional $73.0 million of letters  of
credit (the "letters  of credit commitment").   As  of September  30,
1995,  $150.0  million  was   available  under  the  revolving   line
commitment for  borrowing and  to  support the  Company's  commercial
paper program.    Also, as of September  30, 1995, letters of  credit
totaling $72.4  million were  issued and  outstanding to  secure  the
Company's promissory notes and accrued interest thereon.   Borrowings
under the revolving  line commitment bear  interest at various  rates
which are a function  of, at the Company's  option, either the  prime
rate of a major bank,  the federal funds rate   or a Eurodollar  base
rate.   Under  the terms  of  the  credit facility,  the  Company  is
required to meet  a minimum interest  coverage ratio  and maintain  a
minimum level  of  tangible  net worth.    In  addition,  the  credit
facility   contains   limitations    on   investments,   liens    and
sale/leaseback transactions.

     Long-term debt consists of the following (in millions):

                                   September 30,  December 31,
                                        1995           1994
                                       ------         ------
     Medium Term Notes ..........      $109.0         $113.0
     Promissory notes ...........        68.2           68.2
     Other obligations ..........           -            2.2
                                       ------         ------
                                       $177.2         $183.4
                                       ======         ======

     The Company has  registered $200.0 million  of unsecured  medium
term debt securities  ("Medium Term Notes")  of which $109.0  million
were outstanding at September 30, 1995.  These Medium Term Notes bear
interest at fixed  rates averaging 5.8%  and mature in  approximately
two to eight years.


3.   Income taxes

     The provision for  income taxes  consists of  the following  (in
millions):

                              Three Months Ended   Nine Months Ended
                                 September 30,       September 30,
                                1995      1994      1995      1994
                                -----     -----    ------    ------
        Federal ............    $63.6     $60.9    $173.8    $166.8
        State ..............      4.2      10.5      15.4      27.5
                                -----     -----    ------    ------
          Total ............    $67.8     $71.4    $189.2    $194.3
                                =====     =====    ======    ======

     The decrease in the current year tax rate is due to tax benefits
from the sale of products manufactured  in the Puerto Rico  fill-and-
finish facility which began in the first quarter of 1995.

4.   Contingencies

  Johnson & Johnson arbitrations

     In September  1985,  the Company  granted  Johnson &  Johnson  a
license relating to certain patented technology and know-how of the 
Company to sell a genetically engineered form of recombinant human
erythropoietin, called Epoetin alfa, throughout the United States for
all human uses except  dialysis and diagnostics.   Johnson &  Johnson
sells Epoetin alfa under the brand name PROCRIT(R).

     A number of  disputes have arisen  between Amgen  and Johnson  &
Johnson as  to  their respective  rights  and obligations  under  the
various agreements between them, including the agreement granting the
license (the  "License Agreement").   These  disputes have  been  the
subject of arbitration  proceedings before  Judicial Arbitration  and
Mediation Services, Inc. ("JAMS") in Chicago, Illinois commencing  in
January 1989.  A dispute  that has not yet  been resolved and is  the
subject  of  the  current  arbitration  proceeding  relates  to   the
accounting methodology currently employed by the Company for  Epoetin
alfa sales.   The  Company  and Johnson  &  Johnson are  required  to
compensate each other for Epoetin alfa sales which either party makes
into  the  other  party's  contractual  market.    The  Company   has
established and is employing an accounting methodology to assign  the
proceeds of sales of EPOGEN(R) and PROCRIT(R) in Amgen's and Johnson &
Johnson's respective  contractual markets.    Johnson &  Johnson  has
disputed this methodology and is proposing an alternative methodology
for adoption by the arbitrator.   If, as a result of the  arbitration
proceeding, a methodology different  from that currently employed  by
the Company is instituted to assign the proceeds of sales between the
parties, it may yield results that are different from the results  of
the accounting methodology currently employed by  the Company.  As  a
result of  the arbitration,  it is  possible that  the Company  would
recognize a different level of EPOGENR sales than are currently being
recognized.   As a  result of  the arbitration,  the Company  may  be
required to  pay additional  compensation to  Johnson &  Johnson  for
sales during prior periods, or Johnson  & Johnson may be required  to
pay compensation to the Company for such prior period sales.  Due  to
the  uncertainties  of  any   arbitrated  result,  the  Company   has
established net liabilities that exceed the amounts paid to Johnson &
Johnson.

     A trial  date  is scheduled  for  March 1,  1996  regarding  the
accounting methodologies  and compensation  for  sales by  Johnson  &
Johnson into  Amgen's  contractual market  and  sales by  Amgen  into
Johnson & Johnson's contractual market.  Discovery as to these issues
is in progress.

     The Company  also  filed a  demand  in the  arbitration  seeking
termination of the License Agreement and damages.  A hearing on  this
demand will be scheduled following the adjudication of the accounting
methodologies for Epoetin alfa sales.  On October 30, 1995 Johnson  &
Johnson filed a complaint in the United States District Court for the
District of Delaware  seeking to enjoin  the arbitrator from  hearing
the termination claims and a judgment declaring that JAMS does not have

jurisdiction over the claims.    The Company is unable  to predict at
this time the outcome of this demand or when it will be resolved.

     On October  2, 1995,  Johnson &  Johnson filed  a demand  for  a
separate  arbitration  proceeding  against  the  Company  before  the
American  Arbitration  Association  ("AAA")  in  Chicago,   Illinois.
Johnson &  Johnson  alleges  in this  demand  that  the  Company  has
breached the License Agreement.  The demand also includes allegations
of various antitrust violations.  In  this demand, Johnson &  Johnson
seeks an  injunction,  declaratory relief,  unspecified  compensatory
damages, punitive damages and costs.  The Company has filed a  motion
to  stay  the  arbitration  pending  the  outcome  of  the   existing
arbitration proceedings before JAMS discussed above.  The Company has
also  filed  an  answer  and   counterclaim  denying  that  AAA   has
jurisdiction to  hear or  decide the  claims  stated in  the  demand,
denying the allegations in the demand and counterclaiming for certain
unpaid invoices.

  Synergen litigation

     Acquisition litigation

     The Company and its wholly owned subsidiary, Amgen Boulder Inc.
(formerly Synergen, Inc.), have been  named as defendants in  several
lawsuits  filed  in  connection  with  the  Company's  December  1994
acquisition of Synergen (the ``Acquisition'').  One suit, brought by
plaintiffs seeking to represent a  class of Synergen warrant  holders
who claim to  have been deprived  of the benefit  of their  warrants,
includes a request for an injunction, declaratory relief and  general
damages in the  sum of  $34.3 million  and also  names Amgen  Boulder
Development Corporation as  a defendant.   The balance  of the  suits
have been brought  by plaintiffs  who seek  to represent  a class  of
stockholders of  Synergen common  stock.   These plaintiffs  seek  an
unspecified amount of compensatory  damages, an order rescinding  the
Acquisition and related equitable relief based upon allegations  that
the defendants breached their fiduciary duties by failing to maximize
stockholder  value  and  defrauded  the  plaintiffs  by  omitting  to
disclose allegedly material information concerning Synergen's  future
prospects.

     ANTRIL(TM) litigation

     Several lawsuits  have  been  filed  against  Synergen  alleging
misrepresentations in connection with its research and development of
ANTRIL(TM) for the treatment  of sepsis.  One  suit brought by  three
Synergen stockholders alleges  violations of  state securities  laws,
fraud and  misrepresentation  and  seeks  an  unspecified  amount  of
compensatory damages and punitive damages.  Another suit, proposed as
a class action,  filed by  a limited  partner of  a partnership  with
which Synergen is  affiliated, seeks rescission  of certain  payments
made to one of the defendants  (or unspecified damages not less  than
$50.0 million) and treble damages based on a variety of  allegations.
Broker-dealers who acted  as market makers  in Synergen options  have
also filed  a suit  claiming in  excess of  $3.2 million  in  trading
losses.

     While it is not possible to predict accurately or determine  the
eventual outcome of  the Johnson &  Johnson arbitration  proceedings,
the Synergen litigation or various other legal proceedings (including
patent disputes)  involving  Amgen,  the Company  believes  that  the
outcome of these proceedings will not have a material adverse  effect
on its financial statements.

5.   Capital stock

     During the nine  months ended  September 30,  1995, the  Company
acquired  5.6 million shares of its  common stock at a total cost  of
$199.9 million  under  its  common  stock  repurchase  program.    At
September 30,  1995, $131.3  million of  the amount  approved by  the
Board of Directors remained available for repurchase through December
31, 1995.   

     In July  1995, the  Board of  Directors approved  a  two-for-one
split of the  Company's common stock  effected in the  form of a  100
percent stock dividend.  The dividend  was distributed on August  15,
1995, to stockholders of record on August 1, 1995.  Accordingly,  the
condensed consolidated  financial  statements  and  the  accompanying
notes have been  retroactively adjusted to  give recognition to  this
stock split.


Item 2.   Management's Discussion and Analysis of Financial Condition
          and Results of Operations


Liquidity and Capital Resources

     Cash provided by operating activities  has been and is  expected
to continue to be the Company's primary source of funds.  During  the
nine months  ended September  30,  1995, operations  provided  $548.2
million of cash compared with $347.7  million during the same  period
last year.   The Company had  cash, cash  equivalents and  marketable
securities of $991.7  million at  September 30,  1995, compared  with
$696.7 million at December 31, 1994.

     Capital expenditures totaled $106.8 million for the nine  months
ended September 30, 1995,  compared with $93.7  million for the  same
period a year ago.  Over the  next few years, the Company expects  to
spend approximately  $150.0 million  to $300.0  million per  year  on
capital projects to expand the Company's global operations.

     The Company receives  cash from the  exercise of employee  stock
options.   During the  nine months  ended September  30, 1995,  stock
options and their  related tax  benefits provided  $108.2 million  of
cash compared  with $45.2  million for  the  same period  last  year.
Proceeds from the  exercise of stock  options and  their related  tax
benefits will vary from period to  period based upon fluctuations  in
the market value of the Company's stock relative to the exercise price
of such options, among other factors.

     The Company has a common  stock repurchase program to 
offset the dilutive effect of its  employee benefit stock option  and
stock purchase plans.  Since its inception in 1992 through  September
30, 1995, the Company  has repurchased $793.7  million of its  common
stock and  is  authorized to  purchase  up to  an  additional  $131.3
million through  December 31,  1995.   During the  nine months  ended
September 30,  1995,  the Company  purchased  5.6 million  shares  of
common stock at a cost of  $199.9 million compared with 10.2  million
shares purchased at  a cost of  $226.0 million during  the same  period
last year.

     To provide for  financial flexibility  and increased  liquidity,
the Company has established several sources  of debt financing.   The
Company has a  shelf registration statement  with the Securities  and
Exchange Commission under which it could  issue up to $200.0  million
of Medium  Term Notes.   At  September 30,  1995, $109.0  million  of
Medium Term Notes were outstanding which mature in approximately  two
to eight years.   The Company  has a commercial  paper program  which
provides for short-term borrowings up to an aggregate face amount  of
$200.0 million.  At September 30,  1995, $99.5 million of  commercial
paper was outstanding, generally with  maturities of three months  or
less.   The Company  also  has a  $150.0  million revolving  line  of
credit,  principally  to  support  the  Company's  commercial   paper
program.  No borrowings  on this line of  credit were outstanding  at
September 30, 1995.

     The Company invests its  cash in accordance  with a policy  that
seeks to maximize returns while  ensuring both liquidity and  minimal
risk of principal  loss.  The  policy limits  investments to  certain
types of  instruments issued  by institutions  with investment  grade
credit  ratings,   and   places  restrictions   on   maturities   and
concentration by  type  and  issuer.    The  Company's  fixed  income
investments  are  subject  to  the  risk  of  market  interest   rate
fluctuations, and all  of the  Company's investments  are subject  to
risks associated with  the ability of  the issuers  to perform  their
obligations under the instruments.

     The Company  has a  program to  manage certain  portions of  its
exposure to fluctuations in foreign  currency exchange rates.   These
exposures primarily result from  European sales, partially offset  by
costs incurred in Europe.  The  Company generally hedges the  related
receivables with foreign currency forward contracts, which  typically
mature within six months.  The  Company uses foreign currency  option
and forward  contracts which  generally expire  within 12  months  to
hedge certain  anticipated  future sales.    At September  30,  1995,
outstanding option and  forward contracts totaled  $25.7 million  and
$63.2 million, respectively.

     The Company believes  that existing funds,  cash generated  from
operations, and existing sources of  debt financing will be  adequate
to satisfy its working  capital and capital expenditure  requirements
and  to  support  its  common   stock  repurchase  program  for   the
foreseeable future.    However,  the  Company  may  raise  additional
capital from time to time to take advantage of favorable conditions in

the markets or in connection with the Company's corporate development
activities.

Results of Operations

Product sales

     Product sales increased 14.7% and 17.5%  for the three and  nine
months ended September 30, 1995, respectively, compared with the same
periods last year.

  NEUPOGEN(R) (Filgrastim)

     The Company's worldwide  NEUPOGEN(R) sales  were $230.3  million
and $689.6 million for the three and nine months ended September  30,
1995, respectively.   These amounts represent  increases of 7.3%  and
13.3%, respectively, over the same periods last year.

     Domestic sales  of NEUPOGEN(R)  were $163.7  million and  $486.8
million for  the three  and nine  months  ended September  30,  1995,
respectively.  These amounts represent increases of $3.6 million  and
$36.3 million, or 2.2% and 8.1%, respectively, over the same  periods
last year.  These increases are primarily due to increased usage  of
NEUPOGEN(R) and to  price increases.   Current  quarter results  were
influenced by  accelerated  wholesaler  purchasing  just  before  the
extended July  4  holiday  period, which  created  artificially  high
inventory levels at the  end of the  second quarter, suppressing  the
increase in  third quarter  sales of  NEUPOGEN(R).   Current  quarter
results also reflect the ongoing and  intensifying cost  reduction
pressure in  the health  care  marketplace,  including  the  growing
influence of managed care organizations and the use of guidelines  in
patient care.  This pressure has contributed to the slowing of growth
in domestic  NEUPOGEN(R) usage  over the  past several  years and  is
expected to  continue to  influence such  growth for  the  forseeable
future.

     International sales of  NEUPOGEN(R), primarily  in Europe,  were
$66.6 million and $202.8 million for the three and nine months  ended
September 30, 1995, respectively.  These amounts represent  increases
of $12.0 million and $44.8 million, or 22.0% and 28.4%, respectively,
over the same  periods last year.   Three factors  account for  these
increases:    (1)  the  inclusion  of  sales  from  three  additional
countries as the result of Austria,  Sweden, and Finland joining  the
EU on January 1, 1995, (2) increased market penetration, and (3) the
favorable effects of strengthened foreign  currencies.  Prior to  the
entry of these countries into the  EU, F. Hoffmann La Roche paid  the
Company royalties  on  sales  in  these  countries  under  a  license
agreement.   The Company's  overall share  of the  colony-stimulating
factor market in the EU has decreased slightly since the introduction
in 1994 of competing colony stimulating factor products.

     Quarterly NEUPOGEN(R)  sales  volume  in the  United  States  is
influenced by  a  number  of  factors  including  underlying  demand,
seasonality of  cancer  chemotherapy  administration  and  wholesaler
inventory management practices.  Wholesaler inventory reductions tend
to reduce domestic NEUPOGEN(R) sales in the first quarter each  year.
In prior  years,  NEUPOGEN(R) sales  in  the EU  have  experienced  a
decline to varying degrees in the third quarter due to seasonality.

  EPOGEN(R) (Epoetin alfa)

     EPOGEN(R) sales were $230.3 million  and $644.8 million for  the
three and nine months ended  September 30, 1995, respectively.  These
amounts represent  increases of  $43.3 million  or 23.2%  and  $117.3
million or 22.2% over  the same periods last  year.  These  increases
were primarily  due  to an  increase  in the  U.S.  dialysis  patient
population, the  administration  of  higher doses  of  EPOGEN(R)  per
patient, and,  to  a  lesser extent,  increased  penetration  of  the
dialysis market.

Cost of sales

     Cost of sales  as a percentage  of product sales  was 13.9%  and
15.5% for  the  three  and nine  months  ended  September  30,  1995,
respectively, compared with 14.7% and 15.6% for the same periods last
year.   Cost of  sales  as a  percentage  of product  sales  declined
slightly in the current quarter as benefits of the Puerto Rico  fill-
and-finish facility  were realized.   The  fourth quarter  margin  is
expected to be similar to the third quarter margin.  In 1996, cost of
sales as a percentage of product sales is expected to range from  14%
to 16%.

Research and development

     Research and  development expenses  increased $23.8  million  or
29.1% and $92.1 million or 39.1% for the three and nine months  ended
September 30, 1995, respectively, compared with the same periods last
year.   These increases  are primarily  due to  an expansion  of  the
Company's internal  research and  development staff,  partially as  a
result of the acquisition of Synergen in December 1994.  In addition,
the current year nine month period  includes a $20.0 million  signing
payment made in the first quarter  to The Rockefeller University  for
an exclusive license  to certain technologies.   Annual research  and
development expenses in 1996  are expected to  increase at an  annual
rate exceeding the anticipated 1996 product sales growth rate.

Marketing and selling

     Marketing and selling expenses  increased $7.2 million or  11.6%
and $23.1  million or  13.2%, for  the three  and nine  months  ended
September 30, 1995, respectively, compared with the same periods last
year.    These  increases  primarily  reflect  marketing  efforts  to
increase the number of  patients receiving NEUPOGEN(R) and to bring  
more patients receiving EPOGEN(R) within the target hematocrit
range.  In 1996, marketing and selling expenses combined with general
and  administrative expenses are expected to have an aggregate annual

growth rate lower than the anticipated 1996 annual growth in  product
sales.

General and administrative

     General and administrative  expenses increased  $5.7 million  or
17.9% and $16.4 million or 18.1%, for the three and nine months ended
September 30, 1995, respectively, compared with the same periods last
year.  These increases are primarily  due to staff-related and  legal
expenses.  In 1996, general and administrative expenses combined with
marketing and  selling expenses  are expected  to have  an  aggregate
annual growth rate lower than the  anticipated 1996 annual growth  in
product sales.

Interest and other income

     Interest and other income increased  $8.6 million or 126.5%  and
$30.7 million  or  191.9% during  the  three and  nine  months  ended
September 30, 1995, respectively, compared with the same periods last
year.  These increases are primarily due to: (1) higher current  year
cash balances, (2) capital gains realized in the Company's investment
portfolio during the current year  periods while capital losses  were
incurred in the prior year periods, (3) higher interest rates  earned
by  the  Company's  investment  portfolio  during  the  current  year
periods, and (4) gains on foreign currency transactions. Interest  and
other income is expected to fluctuate from period to period primarily
due to changes in interest rates and cash balances.

Income taxes

     The Company's effective tax rate for  the three and nine  months
ended September 30, 1995  was 31.7% and 32.5%  compared to 38.5%  and
38.2%, respectively, for the same periods last year.  These decreases
in the tax rate were  due to tax benefits  from the sale of  products
manufactured in the Puerto Rico fill-and-finish facility which  began
in the first  quarter of 1995.   These tax  benefits are expected  to
result in an annualized effective tax rate of 31-33% in 1995.

Financial Outlook

     Worldwide NEUPOGEN(R) sales for 1995 are  expected to grow at  a
double digit  rate but  lower  than the  1994  growth rate.    Future
NEUPOGEN(R) sales  increases  are dependent  primarily  upon  further
penetration of existing markets, the timing and nature of  additional
indications for which the product may be approved and the effects  of
competitive products.  NEUPOGEN(R) usage is expected to continue to be
affected by cost containment pressures on health care providers, which
are intensifying because of managed care and guidelines.  In addition,
international NEUPOGEN(R)  sales  will  continue  to  be  subject  to
changes in foreign currency exchange rates and increased competition.

     EPOGEN(R) sales for 1995  are anticipated to  grow at an  annual
rate of more  than 20%.   The Company anticipates  that increases  in
both the U.S. dialysis patient population and dosing will continue to
drive EPOGEN(R)  sales.   EPOGEN(R) sales  may  also be  affected  by

future changes in reimbursement rates or the basis  for reimbursement
by the federal government.

     The  Company  expects  double  digit  earnings  growth  in  1995
primarily as a result of the anticipated increases in product  sales,
increases realized in interest and other income, and the decrease  in
the 1995  tax rate.   The  Company currently  anticipates that  total
product sales and earnings will  grow at  double digit  rates in  1996, 
but these growth rates  are  expected  to be  lower  than  1995  growth 
rates.  Estimates  of  future  product  sales  and  earnings,  however,
are necessarily speculative in nature and  are difficult to predict  
with accuracy.

Legal Matters

     The Company is  engaged in arbitration  proceedings with one  of
its licensees  and various  legal proceedings  relating to  Synergen.
For a  discussion  of these  matters  see  Note 4  to  the  Condensed
Consolidated Financial Statements.

                     PART II - OTHER INFORMATION

Item 1.   Legal Proceedings

     The Company is  engaged in arbitration  proceedings with one  of
its licensees.  For a complete discussion of these matters see Note 4
to the  Condensed  Consolidated  Financial Statements  -  "Johnson  &
Johnson arbitrations".  Other legal proceedings are also reported  in
Note 4 to the Condensed Consolidated Financial Statements and in  the
Company's Form  10-K  for the  year  ended December  31,  1994,  with
material developments since that report described below except to the
extent otherwise reported in the Company's Form 10-Qs for the periods
ended March 31, 1995 and June 30, 1995.  While it is not possible  to
predict accurately  or to  determine the  eventual outcome  of  these
matters, the  Company  believes  that  the  outcome  of  these  legal
proceedings will not have a material adverse effect on the  financial
statements of the Company.

Synergen litigation

     Acquisition litigation

     In Livergood v. Synergen,  Inc., et al., Weld,  et al. v.  Amgen
Inc., et al., and Reineke v. Synergen, Inc., et al., purported  class
action  suits  previously   filed  on  behalf   of  former   Synergen
stockholders challenging the acquisition price, all three suits  were
consolidated in  United States  District  Court, County  of  Boulder,
State of Colorado, and the court  has stayed the proceedings  pending
the outcome of  the Stanley, et  al. v. Soll,  et al. suit  involving
similar claims previously filed in the  Delaware Chancery Court.   In
Glick v. Synergen, Inc.,  et al., a lawsuit  previously brought by  a
class of Synergen warrant holders who claim to have been deprived  of
the benefit  of their  warrants, the  court has  dismissed the  third
amended complaint  but granted  leave to  amend the  complaint.   The

plaintiffs have  amended  the  complaint  to  seek  declaratory  relief 
and an injunction.

     ANTRIL(TM) litigation

     In Temple, et al. v. Synergen,  Inc., et al., a suit  previously
filed in the District Court for the City and County of Denver,  State
of  Colorado,   alleging   misrepresentations  in   connection   with
Synergen's research and development  of ANTRIL(TM) for the  treatment
of sepsis, the  court has stayed  the proceedings  pending an  appeal
filed by the plaintiffs in the United States  District Court for  the
Tenth Circuit.  The  appeal seeks to reverse  a Federal court  ruling
which denied  the plaintiffs'  exclusion from  a prior  class  action
settlement.  If the Tenth Circuit affirms the ruling, the  plaintiffs
will be foreclosed from proceeding in the above mentioned state court
action.

Erythropoietin patent litigation

     This lawsuit was terminated on October  2, 1995 when the  United
States  Supreme  Court  denied  Johnson  &  Johnson's  petition   for
certiorari which sought review  of an April 5,  1995 decision by  the
United States Court of Appeals for the Federal Circuit.


Item 6.   Exhibits and Reports on Form 8-K

     (a)  Reference is made to the Index to Exhibits included herein.

     (b)  Reports on Form 8-K

     The Company filed  a report  on Form  8-K dated  August 31, 1995
reporting a demand filed in an arbitration proceeding with Johnson  &
Johnson seeking:   (1) termination of  the product license  agreement
between the  Company and  Johnson &  Johnson,  (2) an  accounting  of
Johnson & Johnson's spillover sales and (3) damages.


                             SIGNATURES


     Pursuant to the requirements of  the Securities Exchange Act  of
1934, the registrant has duly caused this report to be signed on  its
behalf by the undersigned thereunto duly authorized.


                                     Amgen Inc.
                                     (Registrant)



Date:     11/13/95                   By:/s/ Robert S. Attiyeh
- ------------------                   ------------------------------------
                                        Robert S. Attiyeh
                                        Senior Vice President Finance
                                        and Corporate Development, and
                                        Chief Financial Officer




Date:     11/13/95                   By:/s/ Larry A. May
- ------------------                   ------------------------------------
                                        Larry A. May
                                        Vice President, Corporate
                                        Controller and Chief
                                        Accounting Officer



                             AMGEN INC.

                          INDEX TO EXHIBITS

Exhibit No.                     Description

  3.1       Restated Certificate of Incorporation. (7)
  3.2       Certificate of  Amendment  to  Restated  Certificate  of
            Incorporation, effective as of July 24, 1991. (14)
  3.3       Bylaws, as amended to date. (19)
  4.1       Indenture dated January 1, 1992 between the Company  and
            Citibank N.A., as trustee. (15)
  4.2       Forms of Commercial Paper Master Note Certificates. (18)
 10.1*      Company's Amended  and  Restated  1991 Equity  Incentive
            Plan.
 10.2*      Company's Amended and Restated 1984 Stock Option Plan.
 10.3       Shareholder's Agreement of Kirin-Amgen,  Inc., dated May
            11, 1984, between the Company and Kirin Brewery Company,
            Limited (with  certain confidential  information deleted
            therefrom). (1)
 10.4       Amendment Nos. 1, 2,  and 3, dated March  19, 1985, July
            29, 1985  and December  19, 1985,  respectively, to  the
            Shareholder's Agreement of Kirin-Amgen,  Inc., dated May
            11, 1984 (with certain  confidential information deleted
            therefrom). (3)
 10.5       Product License Agreement, dated September 30, 1985, and
            Technology License Agreement, dated,  September 30, 1985
            between the Company and Ortho Pharmaceutical Corporation
            (with   certain    confidential   information    deleted
            therefrom). (2)
 10.6       Product License Agreement, dated September 30, 1985, and
            Technology License Agreement,  dated September  30, 1985
            between  Kirin-Amgen,  Inc.  and   Ortho  Pharmaceutical
            Corporation  (with   certain  confidential   information
            deleted therefrom). (3)
 10.7*      Company's Employee Stock Purchase Plan, amended April 1,
            1992. (16)
 10.8       Agreement, dated February 12, 1986,  between the Company
            and Sloan-Kettering Institute for  Cancer Research (with
            certain confidential information deleted therefrom). (4)
 10.9       Amendment No. 2, dated November 13,  1990, to Agreement,
            dated February 12, 1986, between the  Company and Sloan-
            Kettering Institute  for Cancer  Research (with  certain
            confidential information deleted therefrom). (13)
 10.10      Research, Development Technology Disclosure  and License
            Agreement PPO, dated  January 20,  1986, by  and between
            the Company and Kirin Brewery Co., Ltd. (4)
 10.11      Research Collaboration Agreement, dated August 31, 1990,
            between Amgen Inc.  and Regeneron  Pharmaceuticals, Inc.
            (with   certain    confidential   information    deleted
            therefrom). (13)

 10.12      Amendment  Nos.  4  and   5,  dated  October   16,  1986
            (effective July 1, 1986) and December 6, 1986 (effective
            July  1,  1986),   respectively,  to   the  Shareholders
            Agreement of Kirin-Amgen, Inc. dated May 11, 1984 (with
            certain confidential information deleted therefrom). (5)  
 10.13      Assignment and  License  Agreement,  dated  October  16,
            1986, between  the Company  and Kirin-Amgen,  Inc. (with
            certain confidential information deleted therefrom). (5)
 10.14      G-CSF European  License  Agreement,  dated December  30,
            1986, between  Kirin-Amgen, Inc.  and the  Company (with
            certain confidential information deleted therefrom). (5)
 10.15      Research  and  Development  Technology   Disclosure  and
            License Agreement: GM-CSF, dated March 31, 1987, between
            Kirin Brewery  Company, Limited  and  the Company  (with
            certain confidential information deleted therefrom). (5)
 10.16*     Company's Amended  and  Restated  1987 Directors'  Stock
            Option Plan.
 10.17      Cross License  Agreement, dated  June  1, 1987,  between
            Amgen Inc. and Amgen Clinical Partners, L.P. (6)
 10.18      Development Agreement, dated June 1, 1987, between Amgen
            Inc. and Amgen Clinical Partners, L.P. (6)
 10.19      Joint Venture  Agreement, dated  June  1, 1987,  between
            Amgen Inc. and Amgen Clinical Partners, L.P. (6)
 10.20      Partnership Purchase  Option  Agreement,  dated June  1,
            1987, between  Amgen Inc.  and Amgen  Clinical Partners,
            L.P. (6)
 10.21*     Company's Amended and Restated 1988 Stock Option Plan.
 10.22*     Company's  Retirement  and  Savings  Plan,  amended  and
            restated as of January 1, 1993. (16)
 10.23      Amendment,   dated   June   30,   1988,   to   Research,
            Development,   Technology    Disclosure   and    License
            Agreement: GM-CSF  dated March  31, 1987,  between Kirin           
            Brewery Company, Limited and the Company. (7)
 10.24      Amending Agreement, dated June 30,  1988, to Development
            Agreement,  Partner  Purchase  Option  Agreement,  Cross
            License Agreement  and  Joint  Venture Agreement,  dated
            June 1,  1987, between  the Company  and Amgen  Clinical
            Partners, L.P. (7)
 10.25      Agreement on G-CSF in the EU,  dated September 26, 1988,
            between Amgen  Inc.  and  F.  Hoffmann-La  Roche  &  Co.
            Limited Company  (with certain  confidential information
            deleted therefrom). (9)
 10.26      Supplementary Agreement  to Agreement  dated January  4,
            1989 to Agreement  on G-CSF in  the EU,  dated September
            26, 1988, between the Company and F. Hoffmann-La Roche &
            Co.  Limited   Company,   (with   certain   confidential
            information deleted therefrom). (9)
 10.27      Agreement on G-CSF in Certain  European Countries, dated
            January 1, 1989, between  Amgen Inc. and  F. Hoffmann-La
            Roche & Co.  Limited Company (with  certain confidential
            information deleted therefrom). (9)
 10.28      Rights Agreement, dated January 24,  1989, between Amgen
            Inc. and  American  Stock  Transfer and  Trust  Company,
            Rights Agent. (8)

 10.29      First Amendment to  Rights Agreement, dated  January 22,
            1991, between Amgen Inc. and American Stock Transfer and
            Trust Company, Rights Agent. (11)
 10.30      Second Amendment  to Rights  Agreement,  dated April  2,
            1991, between Amgen Inc. and American Stock Transfer and
            Trust Company, Rights Agent. (12)
 10.31      Deed of  Trust  and Security  Agreement,  dated June  1,
            1989,  between  the  Company  and  UNUM  Life  Insurance
            Company of America. (10)
 10.32      Note, dated June 1,  1989, between the Company  and UNUM
            Life Insurance Company of America. (10)
 10.33      Agency Agreement, dated November 21, 1991, between Amgen
            Manufacturing,  Inc.  and  Citicorp  Financial  Services
            Corporation. (16)
 10.34      Agency Agreement,  dated  May  21, 1992,  between  Amgen
            Manufacturing,  Inc.  and  Citicorp  Financial  Services
            Corporation. (16)
 10.35      Guaranty, dated July 29,  1992, by the Company  in favor
            of Merck Sharp & Dohme Quimica de Puerto Rico, Inc. (17)
 10.36      936 Promissory  Note No.  01, dated  December 11,  1991,
            issued by Amgen Manufacturing, Inc. (16)
 10.37      936 Promissory  Note No.  02, dated  December 11,  1991,
            issued by Amgen Manufacturing, Inc. (16)
 10.38      936 Promissory Note No. 001, dated July 29, 1992, issued
            by Amgen Manufacturing, Inc. (16)
 10.39      936 Promissory Note No. 002, dated July 29, 1992, issued
            by Amgen Manufacturing, Inc. (16)
 10.40      Guaranty, dated  November 21,  1991, by  the Company  in
            favor of Citicorp Financial Services Corporation. (16)
 10.41      Lease and Agreement relating  to Lease, dated  March 27,
            1986 and  April  1,  1986,  respectively, for  2003  Oak
            Terrace Lane between 2001 Hillcrest  Partnership and the
            Company. (19)
 10.42      Partnership Purchase  Agreement, dated  March 12,  1993,
            between the  Company,  Amgen  Clinical  Partners,  L.P.,
            Amgen  Development  Corporation,  the  Class  A  limited
            partners and the Class B limited partner. (17)
 10.43*     Amgen Supplemental Retirement  Plan dated June  1, 1993.
            (20)
 10.44      Promissory Note of  Mr. Kevin W.  Sharer, dated  June 4,
            1993. (20)
 10.45      Promissory Note of Mr. Larry A.  May, dated February 24,
            1993. (21)
 10.46*     First Amendment dated October 26, 1993  to the Company's
            Retirement and Savings Plan. (21)
 10.47*     Amgen Performance Based Management Incentive Plan. (21)
 10.48      Agreement and Plan of  Merger, dated as of  November 17,
            1994, among  Amgen Inc.,  Amgen Acquisition  Subsidiary,
            Inc. and Synergen, Inc. (22)
 10.49      Third  Amendment  to  Rights  Agreement,   dated  as  of
            February 21, 1995, between Amgen Inc. and American Stock
            Transfer Trust and Trust Company (23)

 10.50      Credit Agreement, dated as of June 23, 1995, among Amgen
            Inc., the  Borrowing  Subsidiaries  named  therein,  the
            Banks named therein, Swiss Bank Corporation and ABN AMRO
            Bank N.V., as Issuing Banks, and Swiss Bank Corporation,
            as Administrative Agent.(24)
 11         Computation of per share earnings.
 27         Financial Data Schedule.
- ----------------
* Management contract or compensatory plan or arrangement.

(1)  Filed as an exhibit to the  Annual Report on Form  10-K for the
     year ended  March 31,  1984 on  June 26,  1984 and  incorporated
     herein by reference.
(2)  Filed as an  exhibit to Quarterly  Report on Form  10-Q for  the
     quarter ended  September  30,  1985 on  November  14,  1985  and
     incorporated herein by reference.
(3)  Filed as an  exhibit to Quarterly  Report on Form  10-Q for  the
     quarter  ended  December  31,  1985  on  February  3,  1986  and
     incorporated herein by reference.
(4)  Filed as an exhibit to Amendment No. 1 to Form S-1  Registration
     Statement (Registration  No.  33-3069)  on March  11,  1986  and
     incorporated herein by reference.
(5)  Filed as an exhibit to the Form 10-K Annual Report for the  year
     ended March 31, 1987 on May 18, 1987 and incorporated herein by    
     reference.
(6)  Filed as an exhibit to the Quarterly Report on Form 10-Q for the
     quarter ended June 30, 1987 on August 12, 1987 and  incorporated
     herein by reference.
(7)  Filed as an exhibit to Form  8 amending the Quarterly Report  on
     Form 10-Q for the quarter ended June 30, 1988 on August 25, 1988
     and incorporated herein by reference.
(8)  Filed as an exhibit to the Form 8-K Current Report dated January
     24, 1989 and incorporated herein by reference.
(9)  Filed as an exhibit  to the Annual Report  on Form 10-K for  the
     year ended  March 31,  1989 on  June 28,  1989 and  incorporated
     herein by reference.
(10) Filed as an exhibit to the Quarterly Report on Form 10-Q for the
     quarter ended June 30, 1989 on August 14, 1989 and  incorporated
     herein by reference.
(11) Filed as an exhibit to the Form 8-K Current Report dated January
     22, 1991 and incorporated herein by reference.
(12) Filed as an exhibit to the  Form 8-K Current Report dated  April
     12, 1991 and incorporated herein by reference.
(13) Filed as an exhibit  to the Annual Report  on Form 10-K for  the
     year ended  March 31,  1991 on  July  1, 1991  and  incorporated
     herein by reference.
(14) Filed as an exhibit  to the Form 8-K  Current Report dated  July
     24, 1991 and incorporated herein by reference.
(15) Filed as an  exhibit to  Form S-3  Registration Statement  dated
     December 19, 1991 and incorporated herein by reference.
(16) Filed as an exhibit  to the Annual Report  on Form 10-K for  the
     year ended December 31, 1992 on March 30, 1993 and  incorporated
     herein by reference.

(17) Filed as an  exhibit to the  Form 8-A dated  March 31, 1993  and
     incorporated herein by reference.
(18) Filed as an exhibit to the Form 10-Q for the quarter ended March
     31, 1993 on May 17, 1993 and incorporated herein by reference.
(19) Filed as an exhibit to the Form 10-Q for the quarter ended  June
     30,  1993  on  August  16,  1993  and  incorporated  herein   by
     reference.
(20) Filed as  an exhibit  to the  Form 10-Q  for the  quarter  ended
     September 30, 1993 on November 12, 1993 and incorporated  herein
     by reference.
(21) Filed as an exhibit  to the Annual Report  on Form 10-K for  the
     year ended December 31, 1993 on March 25, 1994 and  incorporated
     herein by reference.
(22) Filed as  an  exhibit  to the  Form  8-K  Current  Report  dated
     November 18, 1994 on December 2, 1994 and incorporated herein by
     reference.
(23) Filed as  an  exhibit  to the  Form  8-K  Current  Report  dated
     February 21, 1995 on  March 7, 1995  and incorporated herein  by
     reference.
(24) Filed as  an exhibit  to the  Form 10-Q  for the  quarter  ended
     June 30, 1995  on August  11, 1995  and incorporated  herein  by
     reference.



                                                                   EXHIBIT 11



                              AMGEN INC.
                  COMPUTATION OF PER SHARE EARNINGS
                         PRIMARY COMPUTATION
                 (In millions, except per share data)
                             (Unaudited)

                           Three Months Ended     Nine Months Ended
                             September 30,         September 30,
                            1995       1994       1995       1994
                          --------   --------   --------   --------

Net income .............    $145.8     $114.0     $392.1     $314.9
                          ========   ========   ========   ========

Applicable common and
 common stock equivalent
 shares:
Weighted average shares
 of common stock
 outstanding during the
 period ................     265.1      265.8      264.8      266.6

Incremental number of
 shares outstanding
 during the period
 resulting from the
 assumed exercises of
 stock options and
 warrants ..............      16.7       12.7       15.4       13.4
                          --------   --------   --------   --------
Weighted average shares
 of common stock and
 common stock
 equivalents outstanding
 during the period .....     281.8      278.5      280.2      280.0
                          ========   ========   ========   ========

Earnings per common
 share primary .........  $    .52   $    .41   $   1.40   $   1.12
                          ========   ========   ========   ========

      
                                                             EXHIBIT 11



                                     AMGEN INC.
                          COMPUTATION OF PER SHARE EARNINGS
                              FULLY DILUTED COMPUTATION
                        (In millions, except per share data)
                                     (Unaudited)

                           Three Months Ended     Nine Months Ended
                             September 30,         September 30,
                            1995       1994       1995       1994
                          --------   --------   --------   --------

Net income .............    $145.8     $114.0     $392.1     $314.9
                          ========   ========   ========   ========

Applicable common and
 common stock equivalent
 shares:
Weighted average shares
 of common stock
 outstanding during the
 period ................     265.1      265.8      264.8      266.6

Incremental number of
 shares outstanding
 during the period
 resulting from the
 assumed exercises of
 stock options and
 warrants ..............      18.1       13.3       19.0       15.3
                          --------   --------   --------   --------
Weighted average shares
 of common stock and
 common stock
 equivalents outstanding
 during the period .....     283.2      279.1      283.8      281.9
                          ========   ========   ========   ========

Earnings per common
 share fully diluted ...  $    .51   $    .41   $   1.38   $   1.12
                          ========   ========   ========   ========







                            EXHIBIT 10.1

                             AMGEN INC.

           AMENDED AND RESTATED 1991 EQUITY INCENTIVE PLAN



    1.   PURPOSE.

         (a)  The purpose of  the Amended  and Restated 1991  Equity
Incentive Plan (the "Plan") is to provide a means by which  employees
of and  consultants  to  Amgen  Inc.,  a  Delaware  corporation  (the
"Company"), and  its Affiliates,  as  defined in  subparagraph  1(b),
directly or  indirectly through  trusts created  for the  benefit  of
their families, may be given an opportunity to benefit from increases
in value of  the stock  of the Company  through the  granting of  (i)
incentive stock options, (ii) nonqualified stock options, (iii) stock
bonuses, and (iv) rights to purchase restricted stock, all as defined
below.

         (b)  The word "Affiliate"  as used  in the  Plan means  any
parent corporation or subsidiary corporation of the Company, as those
terms are defined in  Sections 424(e) and  (f), respectively, of  the
Internal Revenue Code of 1986, as amended (the "Code").

         (c)  The Company, by means of the Plan, seeks to retain the
services of persons now employed by or serving as consultants to  the
Company, to  secure and  retain the  services of  persons capable  of
filling such positions, and to provide incentives for such persons to
exert maximum efforts for the success of the Company.

         (d)  The Company intends that the  rights issued under  the
Plan ("Stock  Awards")  shall, in  the  discretion of  the  Board  of
Directors of  the Company  (the "Board")  or any  committee to  which
responsibility for  administration of  the  Plan has  been  delegated
pursuant to subparagraph  2(c), be either  (i) stock options  granted
pursuant to paragraph 5 hereof, including incentive stock options  as
that term  is used  in  Section 422  of  the Code  ("Incentive  Stock
Options"), or options which do not qualify as Incentive Stock Options
("Nonqualified Stock Options") (together  hereinafter referred to  as
"Options"), or (ii)  stock bonuses or  rights to purchase  restricted
stock granted pursuant to paragraph 6 hereof.

         (e)  The word  "Trust" as  used in  the Plan  shall mean  a
trust created for the benefit of  the employee or consultant, his  or
her spouse, or members of their immediate family.  The word  optionee
shall mean the person to whom  the option is granted or the  employee
or consultant for whose benefit the option is granted to a Trust,  as
the context shall require.

    2.   ADMINISTRATION.

         (a)  The Plan shall be administered by the Board unless and
until the Board delegates administration to a committee, as  provided
in subparagraph 2(c).

         (b)  The Board shall have the power, subject to, and within
the limitations of, the express provisions of the Plan:

              (1)  To determine  from  time  to  time which  of  the
persons eligible under the Plan shall  be granted Stock Awards;  when
and how Stock Awards shall be granted; whether a Stock Award will  be
an Incentive  Stock  Option, a  Nonqualified  Stock Option,  a  stock
bonus, a right to purchase restricted stock, or a combination of  the
foregoing; the provisions of each Stock Award granted (which need not
be identical), including  the time or  times when a  person shall  be
permitted to purchase or receive stock pursuant to a Stock Award; and
the number of  shares with  respect to  which Stock  Awards shall  be
granted to each such person.

              (2)  To construe  and  interpret  the Plan  and  Stock
Awards granted under it, and to establish, amend and revoke rules and
regulations for its administration.   The Board,  in the exercise  of
this power, may correct any defect, omission or inconsistency in  the
Plan or in any Stock Award,  in a manner and  to the extent it  shall
deem necessary or expedient to make the Plan fully effective.

              (3)  To amend the Plan as provided in paragraph 13.

              (4)  Generally, to exercise such powers and to perform
such acts as the  Board deems necessary or  expedient to promote  the
best interests of the Company.

         (c)  The Board may delegate administration of the Plan to a
committee composed of not fewer than  three (3) members of the  Board
(the "Committee"), all  of the members  of which  Committee shall  be
disinterested persons  and  outside  directors, if  required  and  as
defined by  the  provisions  of subparagraphs  2(d)  and  2(e).    If
administration is delegated to a Committee, the Committee shall have,
in connection  with the     administration of  the Plan,  the  powers
theretofore  possessed  by  the  Board,  subject,  however,  to  such
resolutions, not inconsistent with the provisions of the Plan, as may
be adopted from time to time by the Board.

         (d)  The term "disinterested person", as used in this Plan,
shall mean an  administrator of  the Plan,  whether a  member of  the
Board or of any Committee to which responsibility for  administration
of the Plan has  been delegated pursuant to  subparagraph 2(c):   (i)
who  is  not  at  the  time   he  or  she  exercises  discretion   in
administering the Plan eligible  and has not at  any time within  one
(1) year prior  thereto been eligible  for selection as  a person  to
whom Stock Awards may  be granted pursuant to  the Plan or any  other
plan  of  the  Company  or  any  of  its  affiliates  entitling   the
participants therein to acquire equity  securities of the Company  or
any of its affiliates;  or (ii) who is  otherwise considered to be  a
"disinterested person" in accordance with the rules, regulations or

interpretations of the Securities and Exchange Commission.  Any such
person shall otherwise comply with the requirements of Rule 16b-3 
promulgated under the Securities Exchange Act of 1934, as amended 
(the "Exchange Act"), as from time to time in effect.

         (e)  The term  "outside director,"  as used  in this  Plan,
shall mean an  administrator of  the Plan,  whether a  member of  the
Board or of any Committee to which responsibility for  administration
of the Plan has been delegated pursuant to subparagraph 2(c), who  is
considered to be an "outside director" in accordance with the  rules,
regulations or interpretations of Section 162(m) of the Code.

         (f)  Any requirement that an administrator of the Plan be a
"disinterested person" or "outside director"  shall not apply if  the
Board or the Committee expressly declares that such requirement shall
not apply.

    3.   SHARES SUBJECT TO THE PLAN.

         (a)  Subject to the provisions of paragraph  11 relating to
adjustments upon  changes in  stock, the  stock  that may  be  issued
pursuant to Stock Awards granted under  the Plan shall not exceed  in
the  aggregate  Forty  Eight  Million  (48,000,000)  shares  of   the
Company's $.0001 par value common stock (the "Common Stock").  If any
Stock Award granted  under the Plan  shall for any  reason expire  or
otherwise terminate without having been exercised in full, the Common
Stock not  purchased  under  such  Stock  Award  shall  again  become
available for the Plan.  Shares  repurchased by the Company  pursuant
to any repurchase rights reserved by the Company pursuant to the Plan
shall not be available for subsequent issuance under the Plan.

         (b)  The Common St ock subject to the  Plan may be unissued
shares or reacquired shares, bought on the market or otherwise.

         (c)  An  Incentive  Stock  Option  may  be  granted  to  an
eligible person  under the  Plan only  if the  aggregate fair  market
value (determined at the time the Incentive Stock Option is  granted)
of the Common Stock with respect to which incentive stock options (as
defined by  the Code)  are exercisable  for the  first time  by  such
optionee during any calendar year under all such plans of the Company
and its  Affiliates  does not  exceed  one hundred  thousand  dollars
($100,000).  If it is determined that an entire Option or any portion
thereof does not qualify for treatment  as an Incentive Stock  Option
by reason of exceeding  such maximum, such  Option or the  applicable
portion shall be considered a Nonqualified Stock Option.

    4.   ELIGIBILITY.

         (a)  Incentive  Stock  Options  may  be  granted   only  to
employees (including officers) of the Company  or its Affiliates.   A
director of the Company  shall not be  eligible to receive  Incentive
Stock Options unless such director is also an employee of the Company
or any Affiliate.  Stock Awards other than Incentive Stock Options may

be granted only to employees  (including officers) of or  consultants
to the Company or any Affiliate or to Trusts of any such employee  or
consultant.   A director  of the  Company shall  not be  eligible  to
receive such Stock Awards unless such director is also an employee of
or a consultant to the Company or any Affiliate.

         (b)  A director  shall  in no  event  be el igible for  the
benefits of  the Plan  unless and  until such  director is  expressly
declared eligible to participate in the  Plan by action of the  Board
or the Committee, and only if, at any time discretion is exercised by
the Board or the Committee in the selection of a director as a person
to whom Stock Awards may be  granted, or in the determination of  the
number of shares which  may be covered by  Stock Awards granted to  a
director:   (i)  a  majority of  the  Board  and a  majority  of  the
directors acting in such matter are disinterested persons, as defined
in  subparagraph  2(d);  (ii)   the  Committee  consists  solely   of
"disinterested persons" as defined in subparagraph 2(d); or (iii) the
Plan  otherwise  complies  with   the  requirements  of  Rule   16b-3
promulgated under the Exchange Act, as  from time to time in  effect.
The Board shall otherwise comply with the requirements of Rule  16b-3
promulgated under the Exchange Act, as  from time to time in  effect.
Notwithstanding the  foregoing, the  restrictions set  forth in  this
subparagraph 4(b) shall not apply if the Board or Committee expressly
declares that such restrictions shall not apply.

         (c)  No person  shall  be  eligible  for the  grant  of  an
Incentive Stock Option under the Plan if, at the time of grant,  such
persons owns (or is deemed to  own pursuant to Section 424(d) of  the
Code) stock  possessing more  than ten  percent  (10%) of  the  total
combined voting power of  all classes of stock  of the Company or  of
any of its  Affiliates unless the  exercise price  of such  Incentive
Stock Option is at  least one hundred and  ten percent (110%) of  the
fair market value of the  Common Stock at the  date of grant and  the
Incentive Stock Option  is not  exercisable after  the expiration  of
five (5) years from the date of grant.

         (d)  Stock Awards shall be limited to a  maximum of 250,000
shares of Common Stock per person per calendar year.

    5.   TERMS OF STOCK OPTIONS.

         Each Option shall be  in such form  and shall contain  such
terms and  conditions  as  the Board  or  the  Committee  shall  deem
appropriate.    The  provisions  of  separate  Options  need  not  be
identical, but each  Option shall include  (through incorporation  of
provisions hereof  by  reference  in the  Option  or  otherwise)  the
substance of each of the following provisions:

         (a)  No Option shall be exercisable after the expiration of
ten (10) years from the date it was granted.

         (b)  The exercise price of each Incentive  Stock Option and
each Nonqualified Stock  Option shall be  not less  than one  hundred
percent (100%) of the fair market  value of the Common Stock  subject
to the Option on the date the Option is granted.

         (c)  The purchase price  of Common Stock  acquired pursuant
to an Option  shall be paid,  to the extent  permitted by  applicable
statutes and regulations, either:  (i) in cash at the time the Option
is exercised;  or  (ii)  at  the  discretion  of  the  Board  or  the
Committee, either at the time of grant or exercise of the Option  (A)
by delivery to the Company of  shares of Common Stock of the  Company
that have been held for the period required to avoid a charge to  the
Company's reported earnings and  valued at the  fair market value  on
the date of exercise,  (B) according to a  deferred payment or  other
arrangement with the person to whom the Option is granted or to  whom
the Option is transferred  pursuant to subparagraph  5(d), or (C)  in
any other form of legal consideration  that may be acceptable to  the
Board or the Committee in their discretion.

    In the case of any deferred payment arrangement,  interest shall
be payable at least  annually and shall be  charged at not less  than
the minimum  rate of  interest necessary  to avoid  the treatment  as
interest, under any applicable provisions of the Code, of any amounts
other than amounts stated to be  interest under the deferred  payment
arrangement.

          (d)  An  Option  granted  to  a  natural  person  shall  be
exercisable during the lifetime of such  person only by such  person,
provided that such person during such person's lifetime may designate
a Trust to be such person's beneficiary with respect to any Incentive
Stock Options granted after February 25, 1992 and with respect to any
Nonqualified Stock  Options, and  such beneficiary  shall, after  the
death of the  person to  whom the Option  was granted,  have all  the
rights that  such person  has while  living, including  the right  to
exercise the Option.  In the  absence of such designation, after  the
death of the person to whom  the Option is granted, the Option  shall
be exercisable by the person or persons to whom the optionee's rights
under such  Option  pass  by will  or  by  the laws  of  descent  and
distribution.

         (e)  The total number of shares of Common  Stock subject to
an Option may,  but need not,  be allotted  in periodic  installments
(which may, but need not, be equal).   From time to time during  each
of such  installment  periods,  the  Option  may  become  exercisable
("vest") with respect to some or  all of the shares allotted to  that
period, and  may be  exercised with  respect to  some or  all of  the
shares allotted to such  period and/or any prior  period as to  which
the Option was not fully exercised.  During the remainder of the term
of the Option (if its term extends beyond the end of the  installment
periods), the Option may be exercised from time to time with  respect
to any shares then remaining subject  to the Option.  The  provisions
of this  subparagraph  5(e)  are subject  to  any  Option  provisions
governing the minimum number of shares  as to which an Option may  be
exercised.

         (f)  The Company may require any optionee, or any person to
whom an Option is transferred under subparagraph 5(d), as a condition
of exercising  any  such  Option:  (i)  to  give  written  assurances
satisfactory to the Company as to the optionee's knowledge and

experience in  financial  and business  matters  and/or to  employ  a
purchaser representative  who has  such knowledge  and experience  in
financial and business  matters, and  that he  or she  is capable  of
evaluating, alone or  together with  the purchaser's  representative,
the merits  and risks  of exercising  the Option;  and (ii)  to  give
written assurances  satisfactory to  the  Company stating  that  such
person is acquiring the Common Stock  subject to the Option for  such
person's own account and not with any present intention of selling or
otherwise distributing the Common Stock.  These requirements, and any
assurances given pursuant to such requirements, shall be  inoperative
if: (x) the issuance  of the shares upon  the exercise of the  Option
has been  registered under  a then  currently effective  registration
statement  under  the  Securities  Act  of  1933,  as  amended   (the
"Securities Act");  or  (y)  as  to  any  particular  requirement,  a
determination  is  made  by  counsel   for  the  Company  that   such
requirement need  not be  met in  the  circumstances under  the  then
applicable securities law.

         (g)  An Option  shall  terminate  three  (3)  months  after
termination  of  the  optionee's  employment  or  relationship  as  a
consultant or director with the Company or an Affiliate, unless:  (i)
such termination is  due to such  person's permanent  and total  dis-
ability, within  the meaning  of Section  422(c)(6) of  the Code,  in
which case  the Option  may, but  need not,  provide that  it may  be
exercised at any time within one (1) year following such  termination
of employment or relationship as a  consultant or director; (ii)  the
optionee dies while in the employ of or while serving as a consultant
or director to the Company or  an Affiliate, or within not more  than
three (3) months after termination of such employment or relationship
as a consultant or director, in  which case the Option may, but  need
not, provide that  it may be  exercised at any  time within  eighteen
(18) months following  the death  of the  optionee by  the person  or
persons to whom the optionee's rights under such Option pass by  will
or by the laws of descent and  distribution;  or (iii) the Option  by
its term specifies  either (A) that  it shall  terminate sooner  than
three (3) months  after termination of  the optionee's employment  or
relationship as  a consultant  or director  with  the Company  or  an
Affiliate; or (B) that it may be exercised more than three (3) months
after termination of the optionee's  employment or relationship as  a
consultant or  director  with the  Company  or an  Affiliate.    This
subparagraph 5(g) shall not  be construed to extend  the term of  any
Option or to permit anyone to exercise the Option after expiration of
its term, nor shall it be construed to increase the number of  shares
as to which any Option is exercisable from the amount exercisable  on
the date of termination of the optionee's employment or  relationship
as a consultant or director.

         (h)  The Option  may,  but need  not,  include a  provision
whereby the optionee may elect at any time during the term of his  or
her employment or relationship as a  consultant or director with  the
Company or any Affiliate to exercise the Option as to any part or all
of the shares subject to the Option prior to the stated vesting dates
of the Option.  Any shares so purchased from any unvested installment
or Option  may be  subject to  a  repurchase right  in favor  of  the
Company or  to  any other  restriction  the Board  or  the  Committee
determines to be appropriate.

         (i)  To the extent provided by the terms of an Option, each
optionee may  satisfy any  federal, state  or local  tax  withholding
obligation relating to  the exercise  of such  Option by  any of  the
following means or by  a combination of such  means: (i) tendering  a
cash payment;  (ii)  authorizing the  Company  to withhold  from  the
shares of the Common  Stock otherwise issuable to  the optionee as  a
result of the exercise of the Option a number of shares having a fair
market value less than or equal to the amount of the withholding  tax
obligation; or (iii) delivering to the Company owned and unencumbered
shares of the Common  Stock having a fair  market value less than  or
equal to the amount of the withholding tax obligation.

         (j)  Without in any way limiting the authority of the Board
or Committee to make or not to make grants of Options hereunder,  the
Board or Committee shall have the  authority (but not an  obligation)
to include as part of any Option agreement a provision entitling  the
optionee to a further  Option (a "Re-Load Option")  in the event  the
optionee exercises the Option evidenced  by the Option agreement,  in
whole or in  part, by surrendering  other shares of  Common Stock  in
accordance with this Plan and the terms and conditions of the  Option
agreement.  Any  such Re-Load  Option (i) shall  be for  a number  of
shares equal to the  number of shares surrendered  as part or all  of
the exercise price of such Option; (ii) shall have an expiration date
which is the same as the  expiration date of the Option the  exercise
of which gave rise  to such Re-Load Option;  and (iii) shall have  an
exercise price which is  equal to one hundred  percent (100%) of  the
fair market value of the Common  Stock subject to the Re-Load  Option
on the date of exercise of the original  Option or, in the case of  a
Re-Load Option  which  is an  Incentive  Stock Option  and  which  is
granted to a 10% stockholder (as defined in subparagraph 4(c)), shall
have an exercise price which is equal to one hundred and ten  percent
(110%) of the fair  market value of the  Common Stock subject to  the
Re-Load Option on the date of exercise of the original Option.

    Any such Re-Load Option  may be an Incentive  Stock Option or  a
Nonqualified Stock Option, as the Board or Committee may designate at
the time of the grant of the original Option, provided, however, that
the designation of any  Re-Load Option as  an Incentive Stock  Option
shall be  subject  to the  one  hundred thousand  dollars  ($100,000)
annual  limitation  on  exercisability  of  Incentive  Stock  Options
described in subparagraph 3(c) of the  Plan and in Section 422(d)  of
the Code.   There shall be  no Re-Load Options  on a Re-Load  Option.
Any such  Re-Load Option  shall be  subject  to the  availability  of
sufficient shares under  subparagraph 3(a)  and shall  be subject  to
such other  terms  and  conditions as  the  Board  or  Committee  may
determine.

    6.   TERMS OF STOCK BONUSES AND PURCHASES OF         
    RESTRICTED STOCK

         Each stock  bonus or  restricted stock  purchase  agreement
shall be in such form and shall contain such terms and conditions  as
the Board or  the Committee shall  deem appropriate.   The terms  and
conditions of stock bonus or restricted stock purchase agreements may
change from time to time, and the terms and conditions of separate

agreements need not be identical, but each stock bonus or  restricted
stock purchase  agreement  shall include  (through  incorporation  of
provisions hereof by  reference in  the agreement  or otherwise)  the
substance of each of the following provisions as appropriate:

         (a)  The purchase price under each stock purchase agreement
shall be such amount  as the Board or  Committee shall determine  and
designate in  such agreement.    Notwithstanding the  foregoing,  the
Board or the  Committee may determine  that eligible participants  in
the Plan may be awarded stock pursuant to a stock bonus agreement  in
consideration for past services actually  rendered to the Company  or
for its benefit.

         (b)  No rights  under  a stock  bonus  or restricted  stock
purchase agreement shall be assignable  by any participant under  the
Plan, either voluntarily or  by operation of  law, except where  such
assignment is required by law or expressly authorized by the terms of
the applicable stock bonus or restricted stock purchase agreement.

         (c)  The purchase  price of  stock acquired  pursuant to  a
stock purchase agreement shall  be paid either:   (i) in cash at  the
time of  purchase;  (ii)  at  the discretion  of  the  Board  or  the
Committee, according to a deferred payment or other arrangement  with
the person to whom the  Common Stock is sold;  or (iii) in any  other
form of legal consideration  that may be acceptable  to the Board  or
the Committee in  their discretion.   Notwithstanding the  foregoing,
the Board or the  Committee to which administration  of the Plan  has
been delegated  may award  Common Stock  pursuant  to a  stock  bonus
agreement in consideration for past services actually rendered to the
Company or for its benefit.

         (d)  Shares of Common Stock sold or awarded  under the Plan
may, but need not, be subject to a repurchase option in favor of  the
Company in accordance with a vesting schedule to be determined by the
Board or the Committee.

         (e)  In the event a person ceases  to be an employee  of or
ceases to serve as a consultant  to the Company or an Affiliate,  the
Company may  repurchase or  otherwise reacquire  any  or all  of  the
shares of Common Stock held by  that person which have not vested  as
of the date  of termination  under the terms  of the  stock bonus  or
restricted stock  purchase agreement  between  the Company  and  such
person.

    7.   CANCELLATION AND RE-GRANT OF OPTIONS.

         The Board  or the  Committee shall  have  the authority  to
effect, at any time and  from time to time,  with the consent of  the
affected holders of  Options, (i)  the repricing  of any  outstanding
Options  under  the  Plan  and/or   (ii)  the  cancellation  of   any
outstanding Options  under the  Plan and  the grant  in  substitution
therefor of new Options under the Plan covering the same or different
numbers of shares of Common Stock,  but having an exercise price  per
share not less than one hundred percent (100%) of the fair market value
per share of Common Stock on the new grant date or, in the case of a 10%

stockholder (as  defined in  subparagraph 4(c)),  not less  than  one
hundred and ten percent (110%) of the fair market value per share  of
Common Stock on the new grant date.

    8.   COVENANTS OF THE COMPANY.

         (a)  During the terms of the Stock Awards granted under the
Plan, the Company  shall keep available  at all times  the number  of
shares of Common Stock  required to satisfy such  Stock Awards up  to
the number of shares of Common Stock authorized under the Plan.

         (b)  The Company shall seek to obtain  from each regulatory
commission or agency having jurisdiction over the Plan such authority
as may be required to issue and sell shares of Common Stock under the
Stock Awards granted  under the  Plan; provided,  however, that  this
undertaking shall  not  require the  Company  to register  under  the
Securities Act either  the Plan, any  Stock Award  granted under  the
Plan or any  Common Stock  issued or  issuable pursuant  to any  such
Stock Award.  If, after reasonable efforts, the Company is unable  to
obtain from any  such regulatory commission  or agency the  authority
that counsel for the Company deems necessary for the lawful  issuance
and sale  of  Common Stock  under  the  Plan, the  Company  shall  be
relieved from  any liability  for failure  to issue  and sell  Common
Stock upon  exercise  of such  Stock  Awards unless  and  until  such
authority is obtained.

    9.   USE OF PROCEEDS FROM COMMON STOCK.

         Proceeds from the  sale of Common  Stock pursuant to  Stock
Awards granted under the Plan shall  constitute general funds of  the
Company.

    10.  MISCELLANEOUS.

          (a)  The  Board  or  Committee  shall  have  the  power  to
accelerate the time during  which a Stock Award  may be exercised  or
the time during which  a Stock Award or  any part thereof will  vest,
notwithstanding the provisions  in the Stock  Award stating the  time
during which it  may be exercised  or the time  during which it  will
vest.  Each  Option providing  for vesting  pursuant to  subparagraph
5(e) shall also provide that if the employee or consultant should die
during the term of his or her  employment with the Company or his  or
her affiliation  with  the  Company  as  a  consultant,  the  vesting
schedule of Options granted to such employee or consultant or to  the
Trusts of such employee or consultant shall be accelerated by  twelve
months for each full  year the employee has  been employed by or  the
consultant has  been affiliated  with the  Company.  Options granted
under the Plan that  are outstanding on February  25, 1992, shall  be
amended to  include  the  accelerated vesting  provided  for  in  the
preceding sentence of this Paragraph 10(a).

         (b)  Neither an optionee nor  any person to whom  an Option
is transferred under the provisions of the Plan shall be deemed to be
the holder of, or to have any of the rights of a holder with  respect to,

any shares subject to  such Option unless and  until such person  has
satisfied all requirements for exercise of the Option pursuant to its
terms.

         (c)  Nothing in  the  Plan or  any  instrument executed  or
Stock Award granted pursuant thereto  shall confer upon any  eligible
employee, consultant, director,  optionee or holder  of Stock  Awards
under the Plan any right to continue in the employ of the Company  or
any Affiliate or to  continue acting as a  consultant or director  or
shall affect the right of the  Company or any Affiliate to  terminate
the employment  or consulting  relationship  or directorship  of  any
eligible employee, consultant, director, optionee or holder of  Stock
Awards under the Plan  with or without  cause.  In  the event that  a
holder of  Stock Awards  under the  Plan  is permitted  or  otherwise
entitled to  take a  leave of  absence, the  Company shall  have  the
unilateral right to (i) determine whether such leave of absence  will
be  treated  as  a  termination  of  employment  or  relationship  as
consultant or  director  for purposes  hereof,  and (ii)  suspend  or
otherwise delay the time or times at which exercisability or  vesting
would otherwise occur  with respect to  any outstanding Stock  Awards
under the Plan.

    11.  ADJUSTMENTS UPON CHANGES IN COMMON STOCK.

         If any change is  made in the Common  Stock subject to  the
Plan, or subject to any Stock  Award granted under the Plan  (through
merger,  consolidation,   reorganization,   recapitalization,   stock
dividend,  dividend  in  property  other  than  cash,  stock   split,
liquidating dividend,  combination  of shares,  exchange  of  shares,
change in corporate structure or otherwise), the Plan and outstanding
Stock Awards  will be  appropriately adjusted  in the  class(es)  and
maximum number of shares subject to  the Plan, the maximum number  of
shares which may be granted to a participant in a calendar year,  and
the class(es)  and number  of shares  and price  per share  of  stock
subject to outstanding Stock Awards.

    12.  CHANGE OF CONTROL.

          (a)  Notwithstanding anything to the contrary in this Plan,
in the event of a Change  in Control (as hereinafter defined),  then,
to the extent permitted  by    applicable law:   (i) the time  during
which Stock Awards become  vested shall automatically be  accelerated
so that the  unvested portions of  all Stock Awards  shall be  vested
prior to the  Change in Control  and (ii) the  time during which  the
Options may be exercised shall automatically be accelerated to  prior
to the Change in Control.  Following the acceleration of the  vesting
and exercise periods,  at the  election of  the holder  of the  Stock
Award, the  Stock Award  may  be:   (x)  exercised (with  respect  to
Options) or,  if the  surviving or  acquiring corporation  agrees  to
assume the  Stock  Awards or  substitute  similar stock  awards,  (y)
assumed; or (z) replaced with substitute  stock awards.  Options  not
exercised, substituted  or assumed  prior to  or upon  the Change  in
Control shall be terminated.

         (b)  For purposes of the Plan, a "Change of Control" shall

be deemed to have occurred at any of the following times:

              (i)  Upon  the  acquisition   (other  than   from  the
Company) by  any person,  entity or  "group," within  the meaning  of
Section 13(d)(3) or 14(d)(2) of the Exchange Act (excluding, for this
purpose, the Company or its affiliates, or any employee benefit  plan
of the Company or its affiliates which acquires beneficial  ownership
of voting securities of the Company), of beneficial ownership (within
the meaning  of Rule  13d-3 promulgated  under the  Exchange Act)  of
fifty percent (50%) or more of either the then outstanding shares  of
Common Stock  or the  combined voting  power  of the  Company's  then
outstanding voting  securities  entitled  to vote  generally  in  the
election of directors; or

              (ii)   At the  time individuals  who, as  of April  2,
1991, constitute  the Board  (the "Incumbent  Board") cease  for  any
reason to constitute at least a majority of the Board, provided  that
any person becoming  a director subsequent  to April  2, 1991,  whose
election, or nomination for  election by the Company's  stockholders,
was approved by a vote of at  least a majority of the directors  then
comprising the Incumbent Board (other than an election or  nomination
of an individual whose initial assumption of office is in  connection
with an  actual  or  threatened  election  contest  relating  to  the
election of the Directors of the  Company, as such terms are used  in
Rule 14a-11 of  Regulation 14A  promulgated under  the Exchange  Act)
shall be, for purposes of the Plan, considered as though such  person
were a member of the Incumbent Board; or

              (iii)  Immediately  prior to  the consummation by  the
Company of a  reorganization, merger, consolidation,  (in each  case,
with respect  to  which persons  who  were the  stockholders  of  the
Company  immediately  prior   to  such   reorganization,  merger   or
consolidation do  not, immediately  thereafter, own  more than  fifty
percent (50%) of the combined voting power entitled to vote generally
in  the  election  of  directors   of  the  reorganized,  merged   or
consolidated company's  then  outstanding  voting  securities)  or  a
liquidation or dissolution of  the Company or of  the sale of all  or
substantially all of the assets of the Company; or

              (iv)   The occu rrence of  any other  event  which the
Incumbent Board  in  its  sole discretion  determines  constitutes  a
Change of Control.

    13.  QUALIFIED DOMESTIC RELATIONS ORDERS

          (a)  Anything in the Plan to the contrary  notwithstanding,
rights under Stock Awards  may be assigned to  an Alternate Payee  to
the extent that a QDRO so provides.  (The terms "Alternate Payee" and
"QDRO" are defined  in Subsection (c)  below.)  The  assignment of  a
Stock Award to  an Alternate Payee  pursuant to a  QDRO shall not  be
treated as having caused a new  grant.  The transfer of an  Incentive
Stock Option to an Alternate Payee may, however, cause it to fail  to
qualify as an Incentive Stock Option.   If a Stock Award is  assigned
to an Alternate  Payee, the Alternate  Payee generally  has the  same
rights as the grantee under the terms of the Plan; provided  however, that

(1) the Stock  Award shall  be  subject to  the  same vesting  terms  and
exercise period as if the Stock Award were still held by the grantee,
(2) an Alternate  Payee may  not transfer a  Stock Award  and (3)  an
Alternate Payee is ineligible for Re-Load Options.

          (b)  In the event of the Plan administrator's receipt of  a
domestic relations  order or  other notice  of  adverse claim  by  an
Alternate Payee  of a  grantee  of a  Stock  Award, transfer  of  the
proceeds of the exercise of such Stock Award, whether in the form  of
cash, stock or other property, may be suspended.  Such proceeds shall
thereafter be transferred pursuant  to the terms of  a QDRO or  other
agreement between  the  grantee and  Alternate  Payee.   A  grantee's
ability to  exercise  a  Stock  Award  may  be  barred  if  the  Plan
administrator receives a court order directing the Plan administrator
not to permit exercise.

         (c)  The word "QDRO" as used in the Plan shall mean a court
order (1) that creates or recognizes the right of the spouse,  former
spouse or  child  (an "Alternate  Payee")  of an  individual  who  is
granted a Stock Award to an interest in such Stock Award relating  to
marital property  rights  or support  obligations  and (2)  that  the
administrator of the Plan determines  would be a "qualified  domestic
relations order," as that  term is defined in  section 414(p) of  the
Code and section  206(d) of the  Employee Retirement Income  Security
Act ("ERISA"), but for the fact that the Plan is not a plan described
in section 3(3) of ERISA.

    14.  AMENDMENT OF THE PLAN.

         (a)  The Board  at any  time, and  from time  to time,  may
amend the Plan.  However, except as provided in paragraph 11 relating
to adjustments upon changes in the  Common Stock, no amendment  shall
be effective  unless  approved by  the  stockholders of  the  Company
within twelve  (12)  months  before or  after  the  adoption  of  the
amendment, where the amendment will:

              (i)  Increase the number of shares  reserved for Stock
Awards under the Plan;

             (ii)  Modify the  requirements  as  to eligibility  for
participation in the  Plan to the  extent such modification  requires
stockholder  approval  in   order  for  the   Plan  to  satisfy   the
requirements of Section  422(b) of  the Code  or to  comply with  the
requirements of Rule 16b-3 promulgated under the Exchange Act; or

            (iii)  Modify  the  Plan  in  any  other   way  if  such
modification requires stockholder approval in  order for the Plan  to
satisfy the requirements of Section 422(b)  of the Code or to  comply
with the requirements  of Rule 16b-3  promulgated under the  Exchange
Act.

         (b)  It is expressly contemplated that the  Board may amend
the Plan in  any respect the  Board deems necessary  or advisable  to
provide optionees  with  the  maximum  benefits  provided  or  to  be
provided

under the  provisions of  the Code  and the  regulations  promulgated
thereunder relating  to employee  Incentive Stock  Options and/or  to
bring the  Plan  and/or  Options granted  under  it  into  compliance
therewith.

         (c)  Rights and obligations  under any Stock  Award granted
before amendment of the Plan shall not be altered or impaired by  any
amendment of the Plan, unless:  (i) the Company requests the  consent
of the person  to whom  the Stock Award  was granted;  and (ii)  such
person consents in writing.

    15.  TERMINATION OR SUSPENSION OF THE PLAN.

         (a)  The Board may  suspend or  terminate the  Plan at  any
time.  Unless sooner terminated, the Plan shall terminate on December
31, 2000.  No Stock  Awards may be granted  under the Plan while  the
Plan is suspended or after it is terminated.

         (b)  Rights and obligations under any Stock  Awards granted
while the  Plan is  in effect  shall not  be altered  or impaired  by
suspension or termination of the Plan, except with the consent of the
person to whom the Stock Award was granted.

    16.  EFFECTIVE DATE OF PLAN.

         The Plan shall become effective as determined by the Board,
but no  Stock Awards  granted under  the  Plan shall  be  exercisable
unless and until the  Plan has been approved  by the stockholders  of
the Company and, if required, an  appropriate permit has been  issued
by the Commissioner of Corporations of the State of California.

                            EXHIBIT 10.16

                             AMGEN INC.

       AMENDED AND RESTATED 1987 DIRECTORS' STOCK OPTION PLAN


1.   PURPOSE
    (a)  The purpose of the  1987 Directors' Stock Option Plan  (the
"Plan") is to provide  a means by which  each director of AMGEN  INC.
(the "Company") and its Affiliates, as defined in subparagraph  1(b),
who is not  otherwise an  employee of  the Company  or any  Affiliate
(each such  person being  hereafter referred  to as  a  "Non-Employee
Director") may  be given  an opportunity  to  purchase stock  of  the
Company.
    (b)  The word "Affiliate" as  used in the Plan means any  parent
corporation or subsidiary corporation of  the Company as those  terms
are defined in Sections 424(e) and (f), respectively, of the Internal
Revenue Code of 1986, as amended (the "Code").
    (c)  The  Compan y, by means  of the  Plan, seeks to  retain the
services of  persons now  serving as  Non-Employee Directors  of  the
Company, to  secure and  retain the  services of  persons capable  of
serving in such capacity, and to provide incentives for such  persons
to exert maximum efforts for the success of the Company.
    (d)  The Company intends that the options issued under  the Plan
not be incentive stock options as that term is used in Section 422 of
the Code.

2.   ADMINISTRATION
    (a)  The Plan  shall be administered by  the  Board of  Directors
(the "Board") of  the Company unless  and until  the Board  delegates
administration to a committee, as provided in subparagraph 2(c).
    (b)  The Board shall have the power, subject to, and  within the
limitations of, the express provisions of the Plan:
         (1)  To construe and interpret the Plan and options granted
under it, and to  establish, amend and  revoke rules and  regulations
for its administration.   The Board, in the  exercise of this  power,
may correct any defect, omission or  inconsistency in the Plan or  in
any option agreement,  in a manner  and to the  extent it shall  deem
necessary or expedient to make the Plan fully effective.
         (2)  To amend the Plan as provided in paragraph 11.
         (3)  Generally, to exercise such powers and to perform such
acts as the Board  deems necessary or expedient  to promote the  best
interests of the Company.    (c)       The   Board    may   delegate
administration of the Plan to a committee composed of not fewer  than
three (3) members of the Board (the "Committee"), all of the  members
of which Committee shall be persons who in the opinion of counsel  to
the Company are  "disinterested persons" within  the meaning of  Rule
16b-3 under the Securities Exchange Act  of 1934.  If  administration
is delegated to a Committee, the Committee shall have, in  connection
with the administration of the Plan, the powers theretofore possessed
by the Board, subject, however, to such resolutions, not inconsistent
with the provisions of the Plan, as may be adopted from time to time

by the Board.  The  Board may abolish the  Committee at any time  and
revest in the Board the administration of the Plan.

3.   SHARES SUBJECT TO THE PLAN
    (a)   Subject to  the provisions  of  paragraph 10  relating  to
adjustments upon  changes  in  stock, the  stock  that  may  be  sold
pursuant to options granted  under the Plan shall  not exceed in  the
aggregate one million  eight hundred thousand  (1,800,000) shares  of
the Company's common  stock.  If  any option granted  under the  Plan
shall for any  reason expire  or otherwise  terminate without  having
been exercised in  full, the stock  not purchased  under such  option
shall again become available for the Plan.
    (b)  The  stock subject to  the Plan may  be unissued shares  or
reacquired shares, bought on the market or otherwise.

4.   ELIGIBILITY
    Options shall be granted only  to Non-Employee Directors of  the
Company, or an affiliate of such Non-Employee Directors.

5.   NON-DISCRETIONARY GRANTS
    (a)  On  January 27 of  each year commencing  January 27,  1992,
each person  who is  at  that time  a  Non-Employee Director  of  the
Company,  or  an  affiliate  of  such  Non-Employee  Director,  shall
automatically be granted  under the Plan,  without further action  by
the Company, the Board, or the  Company's stockholders, an option  to
purchase three thousand five hundred  (3,500) shares of common  stock
of the Company  on the terms  and conditions set  forth herein.   The
number of shares  to be granted  hereunder shall not  be adjusted  as
provided for in subparagraph 10(a),  but, however, shall be  adjusted
by multiplying by a fraction, the numerator of which is forty dollars
($40.00) per share and  the denominator of which  is the fair  market
value of the common stock of the Company  on the date of grant.   The
number of shares granted pursuant to this subparagraph 5(a) shall  be
rounded to the nearest  one hundred (100) shares  (rounding up if  50
shares); notwithstanding the foregoing, the number  of shares that
shall be granted pursuant to this subparagraph 5(a) shall not be less
than two thousand  (2,000) nor shall it exceed five thousand (5,000)
shares.  The option shall be on the terms and conditions set forth 
herein and should the date of grant set forth above be a Saturday,
Sunday or legal holiday, such grant shall be made on the next business
day.
    (b)  Each person  who, after January 27  of any year  commencing
January 27, 1991 and prior to November 1 of any year, becomes a  Non-
Employee Director,  or an  affiliate of  such Non-Employee  Director,
shall, upon  the date  he or  such affiliate  becomes a  Non-Employee
Director, automatically be  granted under the  Plan, without  further
action by the Company, the Board,  or the Company's stockholders,  an
option to  purchase three  thousand five  hundred (3,500)  shares  of
common stock of  the Company on  the terms and  conditions set  forth
herein.  The number  of shares to be  granted hereunder shall not  be
adjusted as provided for in  subparagraph 10(a), but, however,  shall
be adjusted by multiplying by a  fraction, the numerator of which  is
forty dollars ($40.00) per share and the denominator of which is  the
fair market value of the common stock  of the Company on the date  of
grant.

The number of shares granted pursuant to this subparagraph 5(b) shall
be rounded to the nearest one hundred (100) shares (rounding up if 50
shares); notwithstanding  the foregoing,  the number  of shares  that
shall be granted pursuant to this subparagraph 5(b) shall not be less
than two thousand (2,000) nor shall  it exceed five thousand  (5,000)
shares.  The option  shall be on the  terms and conditions set  forth
herein and should the  date of grant set  forth above be a  Saturday,
Sunday or  legal  holiday, such  grant  shall  be made  on  the  next
business day.

6.   OPTION PROVISIONS
    Each option shall be in such  form and shall contain such  terms
and conditions as the Board or the Committee shall deem  appropriate.
The provisions of separate  options need not  be identical, but  each
option shall include (through  incorporation of provisions hereof  by
reference in the option  or otherwise) the substance  of each of  the
following provisions:
    (a)  The term of  each  option shall be  ten (10) years from  the
date it was granted.
    (b)  The  exercise price  of each  option shall  be one  hundred
percent (100%) of the fair market value of the stock subject to  such
option on the date such option is granted.
    (c)  The purchase price of stock acquired pursuant to  an option
shall be paid,  to the extent  permitted by  applicable statutes  and
regulations, either (i) in cash
at the  time the  option is  exercised  or (ii)  by delivery  to  the
Company of shares of common stock that have been held for the  period
required to avoid  a charge to  the Company's  reported earnings  and
valued at their fair market value  on the date of exercise.   Options
granted under the Plan that are  outstanding on April 2, 1991,  shall
be amended to include the right to exercise with common stock of  the
Company as provided for in this subparagraph 6(c).
    (d)  An option granted to a natural person shall  be exercisable
during the lifetime of such person only by such person, provided that
such person during such person's lifetime may designate an  affiliate
of such person to  be such person's beneficiary  with respect to  the
Option, and such beneficiary shall, after the death of the person  to
whom the Option was granted, have all of the rights that such  person
had while living, including the right to exercise the Option.  In the
absence of such designation,  after the death of  the person to  whom
the Option is granted, the Option shall be exercisable by the  person
or persons to whom  the optionee's rights under  such Option pass  by
will or by the laws of descent and distribution.
    (e)  An option shall not vest with respect to each  optionee (i)
unless the optionee, or the affiliate  of such optionee, as the  case
may be, has, at the date of grant, provided three (3) years of  prior
continuous service as a Non-Employee Director, or (ii) until the date
upon which such optionee  or the affiliate of  such optionee, as  the
case may be, has  provided one year of  continuous service as a  Non-
Employee Director  following  the  date  of  grant  of  such  option,
whereupon such option  shall become fully  exercisable in  accordance
with its terms, provided that, if the optionee, or the affiliate of such
optionee, as the case may  be, has, at the date of grant, provided
three (3) years of prior continuous service as a Non-Employee

Director, such option shall not become exercisable for six (6) months
after the  date of  grant (even  though such  option shall  be  fully
vested as of the date of grant).
    (f)  The Company may require any optionee, or any person to whom
an option is transferred under subparagraph  6(d), as a condition  of
exercising  any  such  option:    (1)  to  give  written   assurances
satisfactory to  the  Company  as to  the  optionee's  knowledge  and
experience in financial and business matters; and (2) to give written
assurances satisfactory to  the Company stating  that such person  is
acquiring the  stock subject  to the  option  for such  person's  own
account and not with  any present intention  of selling or  otherwise
distributing the stock.  These requirements, and any assurances given
pursuant to  such  requirements,  shall be  inoperative  if  (i)  the
issuance of  the shares  upon the  exercise of  the option  has  been
registered under a  then currently  effective registration  statement
under the Securities Act of 1933, as amended (the "Securities  Act"),
or (ii), as to any particular requirement, a determination is made by
counsel for the Company that such requirement need not be met in  the
circumstances under the then applicable securities laws.
    (g)  Subject to  the last  sentence of  this  subparagraph 6(g),
each option granted after April 2, 1991, under the Plan shall include
and all outstanding options under the Plan on April 2, 1991 shall  be
amended to include a  provision entitling the  optionee to a  further
option (a "Reload Option")  in the event  the optionee exercises  the
option evidenced  by  the option  grant,  in  whole or  in  part,  by
surrendering  other  shares  of  common  stock  of  the  Company   in
accordance with the Plan and the terms of the option grant.  Any such
Reload Option (i) shall be for a number of shares equal to the number
of shares surrendered  as part or  all of the  exercise price of  the
original option; (ii) shall have an expiration date which is the same
as the expiration date of the  original option; and (iii) shall  have
an exercise price which is equal to one hundred percent (100%) of the
fair market value of the common stock subject to the Reload Option on
the date of exercise of the original option.  Any such Reload  Option
shall be  subject  to the  availability  of sufficient  shares  under
subparagraph 3(a).   There  shall be  no Reload  Option on  a  Reload
Option.  The provisions  of this subparagraph  6(g) shall not  become
effective and shall be void unless  and until receipt by the  Company
of an interpretive letter from the Securities and Exchange Commission
or an opinion of counsel reasonably acceptable to the Company to  the
effect that the Plan will be a "formula plan" as defined in Rule 16b-
3(c)(2)(ii)  if  Reload   Options  are  granted   pursuant  to   this
subparagraph 6(g).

7.   COVENANTS OF THE COMPANY
    (a)  During the terms of the options granted under the Plan, the
Company shall keep  available at all  times the number  of shares  of
stock required to satisfy such options.
    (b)   The Company  shall seek  to  obtain from  each  regulatory
commission or agency having jurisdiction over the Plan such authority
as may be required to issue and sell shares of stock upon exercise of
the options  granted under  the Plan;  provided, however,  that  this
undertaking shall  not  require the  Company  to register  under  the
Securities Act either the Plan, any option granted under the Plan, or

any stock issued  or issuable pursuant  to any such  option.  If  the
Company is unable to  obtain from any  such regulatory commission  or
agency the authority  which counsel for  the Company deems  necessary
for the lawful issuance and sale of stock under the Plan, the Company
shall be relieved from  any liability for failure  to issue and  sell
stock upon exercise of such options  unless and until such  authority
is obtained.

8.   USE OF PROCEEDS FROM STOCK
    Proceeds from  the sale  of stock  pursuant  to options  granted
under the Plan shall constitute general funds of the Company.

9.   MISCELLANEOUS
    (a)  Neither  an optionee nor  any person to  whom an option  is
transferred under subparagraph 6(d) shall be deemed to be the  holder
of, or to have  any of the rights  of a holder  with respect to,  any
shares subject  to  such option  unless  and until  such  person  has
satisfied all requirements for exercise of the option pursuant to its
terms.
    (b)  Throughout the te rm of any option granted  pursuant to the
Plan, the Company shall make available to the holder of such  option,
not later than one hundred twenty (120) days after the close of  each
of the Company's fiscal years during  the option term, upon  request,
such  financial  and  other  information  regarding  the  Company  as
comprises the  annual  report  to the  stockholders  of  the  Company
provided for in the by-laws of the Company and such other information
regarding the Company  as the holder  of such  option may  reasonably
request.

10.  ADJUSTMENTS UPON CHANGES IN STOCK
    (a)  If any change is made in the stock subject to  the Plan, or
subject to  any  option  granted  under  the  Plan  (through  merger,
consolidation,  reorganization,  recapitalization,  stock   dividend,
dividend in  property  other  than  cash,  stock  split,  liquidating
dividend, combination  of  shares,  exchange  of  shares,  change  in
corporate structure or otherwise),  the Plan and outstanding  options
will be appropriately adjusted in the class(es) and maximum number of
shares subject to the Plan and the class(es) and number of shares and
price per share  of stock subject  to outstanding options;  provided,
that the minimum and maximum number  of shares of common stock to  be
granted as provided for in subparagraphs  5(a) and 5(b) shall not  be
adjusted for any stock split, combination  of shares or common  stock
dividend.
     (b)  Notwithstanding anything to the  contrary in this Plan,  in
the event of a Change in  Control (as hereinafter defined), then,  to
the extent permitted by  applicable law:  (i)  the time during  which
options become vested shall automatically be accelerated so that  the
unvested portions of all options shall be vested prior to the  Change
in Control  and  (ii)  the  time during  which  the  options  may  be
exercised shall automatically be accelerated  to prior to the  Change
of Control.   Upon  or  after the  acceleration  of the  vesting  and
exercise periods, at the election of the holders of the options,  the
options may be:   (x)  exercised or,  if the  surviving or  acquiring
corporation agrees  to  assume  the  options  or  substitute  similar
options, (y) assumed; or (z) replace with substitute options.  Options

not exercised, substituted or assumed prior to or upon the Change in
Control  shall  be terminated.
          (c)  For purposes of the Plan, a "Change of Control"  shall
be deemed to have occurred at any of the following times:
               (i)  Upon  the  acquisition   (other  than  from   the
Company) by  any person,  entity or  "group," within  the meaning  of
Section 13(d) (3) or 14(d) (2) of the Securities Exchange Act of 1934
as amended (the  "Exchange Act")  (excluding, for  this purpose,  the
Company or  its  affiliates, or  any  employee benefit  plan  of  the
Company or  its affiliates  which  acquires beneficial  ownership  of
voting securities of  the Company), of  beneficial ownership  (within
the meaning  of Rule  13d-3 promulgated  under the  Exchange Act)  of
fifty percent (50%) or more of either the then outstanding shares  of
Common Stock  or the  combined voting  power  of the  Company's  then
outstanding voting  securities  entitled  to vote  generally  in  the
election of directors; or
               (ii) At the  time individuals who,  as of October  23,
1995, constitute the Board (the "Incumbent
Board") cease for any reason to constitute at least a majority of the
Board, provided that  any person  becoming a  director subsequent  to
October 23, 1995, whose election, or  nomination for election by  the
Company's stockholders, was approved by a vote of at least a majority
of the directors then comprising the  Incumbent Board (other than  an
election or nomination of an  individual whose initial assumption  of
office is in connection with an actual or threatened election contest
relating to the  election of the  Directors of the  Company, as  such
terms are used in Rule 14A-11 of Regulation 14A promulgated under the
Exchange Act)  shall be,  for purposes  of  the Plan,  considered  as
though such person were a member of the Incumbent Board; or
              (iii) Immediately  prior to  the  consummation by  the
Company of a  reorganization, merger, consolidation,  (in each  case,
with respect  to  which persons  who  were the  stockholders  of  the
Company  immediately  prior   to  such   reorganization,  merger   or
consolidation do  not, immediately  thereafter, own  more than  fifty
percent (50%) of the combined voting power entitled to vote generally
in  the  election  of  directors   of  the  reorganized,  merged   or
consolidated company's  then  outstanding  voting  securities)  or  a
liquidation or dissolution of  the Company or of  the sale of all  or
substantially all of the assets of the Company.

11.  AMENDMENT OF THE PLAN
    (a)  The Board at any time, and from time to time, may amend the
Plan; provided, however, that the Board shall not amend the Plan more
than once every six months with respect to the provisions of the Plan
relating to the amount,  price, and timing of  grants, other than  to
comply with  changes  in the  Code,  the Employee  Retirement  Income
Security Act of 1974, as amended, or the regulations thereunder.
    (b)   Rights and  obligations under  any  option granted  before
amendment of  the  Plan shall  not  be  altered or  impaired  by  any
amendment of the Plan, except with the consent of the person to  whom
the option was granted.

12.  TERMINATION OR SUSPENSION OF THE PLAN

    (a)  The Board  may suspend or terminate  the Plan at any  time.
Unless sooner terminated, the Plan shall terminate ten (10) years from

the date the Plan is adopted by the Board.  No options may be granted
under the Plan while the Plan is suspended or after it is terminated.
    (b)  Rights and obligations under  any option granted while  the
Plan is in effect shall not  be altered or impaired by suspension  or
termination of the  Plan, except with  the consent of  the person  to
whom the option was granted.

13.  EFFECTIVE DATE OF PLAN
    The Plan became effective  as of January 27,  1987.  No  options
granted under the Plan  as the result of  the amendments on July  24,
1990 and April  2, 1991 shall  be exercisable unless  and until  said
amendment is approved by the stockholders of the Company, and to  the
extent required or necessary under applicable law, amendments made on
April  2,  1991  shall  not  be  effective  until  approved  by   the
stockholders of the Company.






                            EXHIBIT 10.2

                             AMGEN INC.

            AMENDED AND RESTATED 1984 STOCK OPTION PLAN

    1.   PURPOSE.

         (a)  The purpose  of the  Plan is  to provide  a means  by
which selected  employees,  directors (if  declared  eligible  under
paragraph 4) and consultants to  Amgen Inc., a Delaware  corporation
(the "Company"),  and its  Affiliates,  as defined  in  subparagraph
1(b), directly or indirectly through trusts for the benefit of their
families, may  be given  an opportunity  to  purchase stock  of  the
Company.

         (b)  The word "Affiliate"  as used in  the Plan  means any
parent corporation  or subsidiary  corporation  of the  Company,  as
those terms are defined in Sections 424(e) and (f), respectively, of
the Internal Revenue Code of 1986, as amended (the "Code").

         (c)  The Company, by  means of the  Plan, seeks to  retain
the services of persons now holding positions, to secure and  retain
the services of persons  capable of filling  such positions, and  to
provide incentives for such persons to exert maximum efforts for the
success of the Company.

         (d)  The Company intends that the options issued under the
Plan shall,  in the  discretion of  the Board  of Directors  of  the
Company (the "Board") or any  committee to which responsibility  for
administration  of  the   Plan  has  been   delegated  pursuant   to
subparagraph 2(c), be either incentive stock options as that term is
used in  Section 422  of the  Code ("Incentive  Stock Options"),  or
options  which   do  not   qualify   as  Incentive   Stock   Options
("Nonincentive Stock  Options").   All options  shall be  separately
designated Incentive Stock Options or Nonincentive Stock Options  at
the time of grant, and in such form as issued pursuant to  paragraph
5, and a separate  certificate or certificates  shall be issued  for
shares purchased on exercise of each type of option.

          (e)  The word  "Trust" as  used in  the Plan  shall mean  a
trust created for the benefit of  the employee or consultant, his  or
her spouse, or members of their immediate family.  The word  optionee
shall mean the person to whom  the option is granted or the  employee
or consultant for whose benefit the option is granted to a Trust,  as
the context shall require.

    2. ADMINISTRATION.

         (a)  The Plan shall  be administered  by the Board  unless
and until  the Board  delegates administration  to a  committee,  as
provided in subparagraph 2(c).

         (b)  The Board  shall  have  the power,  subject  to,  and
within the limitations of, the express provisions of the Plan:

              (1)  To determine  from  time to  time  which of  the
persons eligible under the Plan shall  be granted options; when  and
how the  option shall  be granted;  whether the  option will  be  an
Incentive  Stock  Option  or   a  Nonincentive  Stock  Option;   the
provisions of each  option granted  (which need  not be  identical),
including the time or  times during the term  of each option  within
which all  or portions  of such  option may  be exercised;  and  the
number of shares for which an  option shall be granted to each  such
person.

              (2)  To construe and  interpret the Plan  and options
granted under  it, and  to establish,  amend  and revoke  rules  and
regulations for its administration.  The  Board, in the exercise  of
this power, may correct any defect, omission or inconsistency in the
Plan or in any option  agreement, in a manner  and to the extent  it
shall deem necessary or expedient to make the Plan fully effective.

              (3)  To amend the Plan as provided in paragraph 10.

              (4)  Generally,  to  exercise  such   powers  and  to
perform such  acts as  the Board  deems  necessary or  expedient  to
promote the best interests of the Company.

         (c)  The Board may delegate administration of  the Plan to
a committee composed  of not  fewer than  three (3)  members of  the
Board (the "Committee"), all of the members of which Committee shall
be  disinterested  persons,  if  required  and  as  defined  by  the
provisions of subparagraph 2(d).  If administration is delegated  to
a Committee,  the  Committee  shall have,  in  connection  with  the
administration of the Plan, the powers theretofore possessed by  the
Board, subject, however, to such resolutions, not inconsistent  with
the provisions of the Plan, as may  be adopted from time to time  by
the Board.   The Board  may abolish the  Committee at  any time  and
revest in the Board the administration of the Plan.

         (d)  The term  "disinterested  person",  as used  in  this
Plan, shall mean an administrator of  the Plan, whether a member  of
the  Board  or  of  any   Committee  to  which  responsibility   for
administration  of  the   Plan  has  been   delegated  pursuant   to
subparagraph 2(c):  (i) who is not  at the time he or she  exercises
discretion in administering  the Plan eligible  and has  not at  any
time within one (1) year prior  thereto been eligible for  selection
as a person to whom stock may be allocated or to whom stock  options
or stock appreciation rights may be granted pursuant to the Plan  or
any other plan of the Company or any of its Affiliates entitling the
participants therein  to  acquire  stock,  stock  options  or  stock
appreciation rights of the Company or any of its Affiliates; or (ii)
who is  otherwise  considered  to be  a  "disinterested  person"  in
accordance with  the  rules,  regulations  or  interpreters  of  the
Securities and Exchange Commission.  Any such person shall otherwise
comply with the  requirements of  Rule 16b-3  promulgated under  the
Securities Exchange Act of 1934, as amended (the "Exchange Act"), as
from time to time in effect.

    3.   SHARES SUBJECT TO THE PLAN.

         (a)  Subject to the provisions of paragraph  9 relating to
adjustments upon  changes  in stock,  the  stock that  may  be  sold
pursuant to options granted under the  Plan shall not exceed in  the
aggregate twenty million four  hundred thousand (20,400,000)  shares
of the Company's $.0001 par value common stock (the "Common Stock").
If any option granted under the Plan shall for any reason expire  or
otherwise terminate  without  having  been exercised  in  full,  the
Common Stock  not purchased  under such  option shall  again  become
available for the Plan.

         (b)  The Common Stock subject to the Plan  may be unissued
shares or reacquired shares, bought on the market or otherwise.

         (c)  An Incentive  Stock  Option  may  be  granted  to  an
eligible person under  the Plan only  if the  aggregate fair  market
value (determined as  of the  times the  respective Incentive  Stock
Options are  granted) of  the Common  Stock  with respect  to  which
Incentive Stock Options are exercisable for  the first time by  such
optionee during  any  calendar year  under  all such  plans  of  the
Company and  its Affiliates  does not  exceed one  hundred  thousand
dollars ($100,000).  Should it be determined that any portion of  an
Incentive Stock Option granted under the  Plan does not qualify  for
treatment as an Incentive Stock Option  by reason of exceeding  such
maximum, such option shall be considered a Nonincentive Stock Option
to the extent, but only to the extent, of such excess.  Should it be
determined that an entire option does  not qualify for treatment  as
an Incentive Stock Option,  such option shall,  in its entirety,  be
considered a Nonincentive Stock Option.

    4.   ELIGIBILITY.

         (a)  Incentive  Stock  Options  may  be  granted  only  to
employees of  the  Company or  its  Affiliates, and  a  director  or
officer of the Company  shall not be  eligible to receive  Incentive
Stock Options unless such director or officer is also an employee of
the Company or  any Affiliate.   Nonincentive Stock  Options may  be
granted only to employees of, or consultants to, the Company or  its
Affiliates (including directors  or officers who  so qualify) or  to
Trusts of any such employee or consultant.

         (b)  A director  shall in  no event  be  eligible for  the
benefits of the  Plan unless and  until such  director is  expressly
declared eligible to participate in the Plan by action of the  Board
or the Committee, and only if,  at any time discretion is  exercised
by the Board  in the selection  of a director  as a  person to  whom
options may be  granted, or in  the determination of  the number  of
shares which may be covered by options granted to a director:  (i) a
majority of the Board and a majority of the directors acting in such
matter are disinterested persons,  as defined in subparagraph  2(d);
(ii) the  Committee consists  solely of  "disinterested persons"  as
defined in subparagraph 2(d); or  (iii) the Plan otherwise  complies
with the requirements of Rule 16b-3 promulgated under the Exchange Act.

The Board shall otherwise comply with the requirements of Rule 16b-3
promulgated under the Exchange Act, as from time to time in effect.

         (c)  No person  shall  be eligible  for  the grant  of  an
Incentive Stock Option under the Plan if, at the time of grant, such
person owns (or is deemed to  own pursuant to Section 425(d) of  the
Code) stock  possessing more  than ten  percent (10%)  of the  total
combined voting power of all classes  of stock of the Company or  of
any of its Affiliates  unless the exercise  price of such  Incentive
Stock Option is at least one hundred ten percent (110%) of the  fair
market value of the Common Stock at  the date of grant and the  term
of the Incentive Stock  Option does not exceed  five (5) years  from
the date of grant.

    5.   OPTION PROVISIONS.

         Each option shall be in  such form and shall  contain such
terms and  conditions  as the  Board  or the  Committee  shall  deem
appropriate.   The  provisions  of  separate  options  need  not  be
identical, but each option  shall include (through incorporation  of
provisions hereof  by  reference in  the  option or  otherwise)  the
substance of each of the following provisions:

         (a)  The term of any option shall not be  greater than ten
(10) years from the date it was granted.

         (b)  The exercise  price of  each  Incentive Stock  Option
shall be not less than one hundred percent (100%) of the fair market
value of the  Common Stock  subject to the  option on  the date  the
option is granted.   The exercise price  of each Nonincentive  Stock
Option shall be not less than eighty-five percent (85%) of the  fair
market value of the Common Stock  subject to the option on the  date
the option is granted.

         (c)  The purchase price of Common Stock  acquired pursuant
to an option shall  be paid, to the  extent permitted by  applicable
statutes and regulations, either (i) in cash at the time the  option
is exercised,  or  (ii)  at  the discretion  of  the  Board  or  the
Committee, either at the time of grant or exercise of the option (A)
by delivery to the Company of other Common Stock of the Company, (B)
according to  a deferred  payment or  other arrangement  (which  may
include, without limiting the generality  of the foregoing, the  use
of other Common Stock  of the Company) with  the person to whom  the
option is granted or to whom  the option is transferred pursuant  to
subparagraph 5(d), or (C) in any  other form of legal  consideration
that may  be acceptable  to  the Board  or  the Committee  in  their
discretion.

    In the case of any deferred payment arrangement, interest shall
be payable at least annually and  shall be charged at not less  than
the minimum rate  of interest necessary  to avoid  the treatment  as
interest, under  any  applicable  provisions of  the  Code,  of  any
amounts other than amounts stated to be interest under the  deferred
payment arrangement.

         (d)  An option  granted  to  a  natural  person  shall  be
exercisable during the lifetime of such person only by such  person,
provided  that  such  person  during  such  person's  lifetime   may
designate a Trust to  be such person's  beneficiary with respect  to
any Incentive Stock Options granted after February 25, 1992 and with
respect to  any Nonincentive  Stock  Options, and  such  beneficiary
shall, after the death of the person to whom the option was granted,
have all the rights that such person has while living, including the
right to exercise the option.   In the absence of such  designation,
after the death  of the person  to whom the  option is granted,  the
option shall be  exercisable by the  person or persons  to whom  the
optionee's rights under such option pass  by will or by the laws  of
descent and distribution.

         (e)  The total number of shares of Common Stock subject to
an option may, but  need not, be  allotted in periodic  installments
(which may, but need not, be equal).  From time to time during  each
of such  installment  periods,  the option  may  be  exercised  with
respect to some or all of the shares allotted to that period, and/or
with respect to  some or  all of the  shares allotted  to any  prior
period as to which the option  was not fully exercised.  During  the
remainder of the term of the option (if its term extends beyond  the
end of the installment  periods), the option  may be exercised  from
time to time with  respect to any shares  then remaining subject  to
the option.  The provisions of this subparagraph 5(e) are subject to
any option provisions governing the minimum  number of shares as  to
which an option may be exercised.

         (f)  The Company may require  any optionee, or  any person
to whom  an option  is transferred  under  subparagraph 5(d),  as  a
condition of  exercising  any such  option:   (1)  to  give  written
assurances  satisfactory  to  the  Company  as  to  the   optionee's
knowledge and experience in financial and business matters and/or to
employ  a  purchaser  representative  who  has  such  knowledge  and
experience in financial and business matters, and that he or she  is
capable of  evaluating,  alone  or  together  with  the  purchaser's
representative, the merits and risks  of exercising the option;  and
(2) to give written assurances  satisfactory to the Company  stating
that such person is acquiring the Common Stock subject to the option
for such person's own account and not with any present intention  of
selling  or  otherwise  distributing   the  Common  Stock.     These
requirements,  and   any   assurances   given   pursuant   to   such
requirements, shall be inoperative if (i) the issuance of the shares
upon the exercise  of the option  has been registered  under a  then
currently effective registration statement under the Securities  Act
of 1933,  as amended  (the  "Securities Act");  or  (ii) as  to  any
particular requirement, a determination is  made by counsel for  the
Company that such requirement need not  be met in the  circumstances
under the then applicable federal securities laws.

         (g)  An option  shall  terminate  three (3)  months  after
termination of  the  optionee's  employment  or  relationship  as  a
consultant with  the  Company  or  an  Affiliate,  unless  (i)  such
termination is due to such person's permanent and total disability,

within the meaning of Section 422(c)(6)  of the Code, in which  case
the option may, but  need not, provide that  it may be exercised  at
any  time  within  one  (1)  year  following  such  termination   of
employment or relationship  as a  consultant; or  (ii) the  optionee
dies while in the employ of or while serving as a consultant to  the
Company or an Affiliate,  or within not more  than three (3)  months
after  termination  of   such  employment  or   relationship  as   a
consultant, in which case the option may, but need not, provide that
it may  be  exercised  at  any  time  within  eighteen  (18)  months
following the death of the optionee by the person or persons to whom
the optionee's rights under such option pass by will or by the  laws
of descent and distribution; (iii) the option by its terms specifies
that  it  shall  terminate  sooner  than  three  (3)  months   after
termination of  the  optionee's  employment  or  relationship  as  a
consultant; or (iv)  that it may  be exercised more  than three  (3)
months  after   termination   of  the   optionee's   employment   or
relationship as a consultant with the Company or an Affiliate.  This
subparagraph 5(g) shall not be construed  to extend the term of  any
option or to permit anyone to  exercise the option after  expiration
of its term,  nor shall it  be construed to  increase the number  of
shares as  to  which  any option  is  exercisable  from  the  amount
exercisable on the date of termination of the optionee's  employment
or relationship as a consultant.

         (h)  The option  may, but  need not,  include a  provision
whereby the optionee may elect at any time during the term of his or
her employment or relationship as a  consultant with the Company  or
any Affiliate to exercise the  option as to any  part or all of  the
shares subject to the option prior to the stated vesting date of the
option or  of  any  installment or  installments  specified  in  the
option.  Any shares  so purchased from  any unvested installment  or
option may be subject to a repurchase right in favor of the  Company
or to any other restriction the Board or the Committee determines to
be appropriate.

         (i)  To the extent provided by the terms of an option, the
optionee may satisfy  any federal,  state or  local tax  withholding
obligation relating to  the exercise of  such option by  any of  the
following means or by a combination  of such means: (1) tendering  a
cash payment;  (2)  authorizing the  Company  to withhold  from  the
shares of the Common Stock otherwise issuable to the participant  as
a result of  the exercise  of the stock  option a  number of  shares
having a fair market value less than  or equal to the amount of  the
withholding tax obligation; or (3)  delivering to the Company  owned
and unencumbered shares  of the Common  Stock having  a fair  market
value less  than or  equal  to the  amount  of the  withholding  tax
obligation.

         (j)  Without in  any  way limiting  the  authority of  the
Board or  Committee  to  make  or not  to  make  grants  of  Options
hereunder, the Board or Committee shall have the authority (but  not
an obligation) to include as part  of any Option agreement, and  all
outstanding Nonincentive Stock Options, to the extent there are unvested
options on June 30, 1991, shall be amended to include, a provision
entitling the optionee to a further Option (a "Re-Load Option") in the
event the optionee exercises the Option evidenced by the Option agreement,

in whole or in part, by surrendering other shares of Common Stock in
accordance with this Plan and the terms and conditions of the Option
agreement.  Any  such Re-Load Option  (i) shall be  for a number  of
shares equal to the number of  shares surrendered as part or all  of
the exercise price of such Option  (or surrendered for shares  which
were  unvested  on  June  30,  1991  in  the  case  of  an   amended
Nonincentive Stock Option); (ii) shall have an expiration date which
is the same  as the expiration  date of the  Option the exercise  of
which gave rise to such Re-Load Option; (iii) shall have an exercise
price which  is equal  to one  hundred percent  (100%) of  the  fair
market value of the  Common Stock subject to  the Re-Load Option  on
the date of exercise of the original Option or, in the case of a Re-
Load Option which is an Incentive Stock Option and which is  granted
to a 10% stockholder (as defined  in subparagraph 4(c)), shall  have
an exercise price  which is  equal to  one hundred  and ten  percent
(110%) of the fair market value  of the Common Stock subject to  the
Re-Load Option on the date of  exercise of the original Option;  and
(iv)  shall  be  granted  under  the  1988  Stock  Option  Plan,  if
sufficient shares  are available  under  subparagraph 3(a)  of  that
Plan, and if sufficient shares of Common Stock are not so available,
shall be granted under the 1991 Equity Incentive Plan to the  extent
shares of Common Stock are available under that Plan.

    Any such Re-Load Option may be  an Incentive Stock Option or  a
Nonincentive Stock Option, as the  Board or Committee may  designate
at the time of the grant of the original Option, except that all Re-
Load  Options  on  unvested  shares  (as   of  June  30,  1991)   of
Nonincentive Stock  Options  shall be  Nonincentive  Stock  Options,
provided, however, that the designation of any Re-Load Option as  an
Incentive Stock Option shall be subject to the one hundred  thousand
dollars ($100,000) annual limitation on exercisability of  Incentive
Stock Options  described in  subparagraph 3(c)  of the  Plan and  in
Section 422(d) of the Code.  There shall be no Re-Load Options on  a
Re-Load Option.   Any such Re-Load  Option shall be  subject to  the
availability of sufficient  shares under the  Amgen Inc. 1988  Stock
Option Plan or under the Amgen  Inc. 1991 Equity Incentive Plan  and
shall be subject to such other terms and conditions as the Board  or
Committee may determine.

    6.   COVENANTS OF THE COMPANY.

         (a)  During the  terms of  the options  granted under  the
Plan, the Company shall  keep available at all  times the number  of
shares of Common Stock required to satisfy such options.

         (b)  The Company shall seek to obtain from each regulatory
commission or  agency  having jurisdiction  over     the  Plan  such
authority as may be required to issue and sell shares of stock  upon
exercise of the options granted  under the Plan; provided,  however,
that this  undertaking shall  not require  the Company  to  register
under the Securities Act either the  Plan, any option granted  under
the Plan or any Common Stock issued or issuable pursuant to any such
option.   If, after reasonable efforts, the Company is unable to obtain
from any such regulatory commission or agency the authority that counsel

for the Company deems necessary for the lawful issuance and sale  of
stock under  the  Plan,  the Company  shall  be  relieved  from  any
liability for failure to issue and  sell Common Stock upon  exercise
of such options unless and until such authority is obtained.

    7.   USE OF PROCEEDS FROM COMMON STOCK.

         Proceeds from the sale of Common Stock pursuant to options
granted under  the  Plan  shall  constitute  general  funds  of  the
Company.

    8.   MISCELLANEOUS.

          (a)  The Board or  the Committee  shall have  the power  to
accelerate the time during  which an option may  be exercised or  the
time during which an option or any part thereof will vest pursuant to
subparagraph 5(e),  notwithstanding  the  provisions  in  the  option
stating the time during which it may be exercised or the time  during
which it will vest.   Each option providing  for vesting pursuant  to
subparagraph  5(e)  shall  also  provide  that  if  the  employee  or
consultant should die during the term  of his or her employment  with
the Company  or  his  or  her  affiliation  with  the  Company  as  a
consultant, the vesting schedule of options granted to such  employee
or consultant or to the Trusts  of such employee or consultant  shall
be accelerated by twelve months for  each full year the employee  has
been employed  by or  the consultant  has  been affiliated  with  the
Company.  Options granted  under the  Plan  that are  outstanding  on
February 25,  1992,  shall  be amended  to  include  the  accelerated
vesting provided  for in  the preceding  sentence of  this  Paragraph
8(a).

         (b)  Neither an optionee nor any person to  whom an option
is transferred under  subparagraph 5(d) shall  be deemed  to be  the
holder of, or to have any of the rights of a holder with respect to,
any shares subject to such option  unless and until such person  has
satisfied all requirements  for exercise of  the option pursuant  to
its terms.

         (c)  Throughout the term of any option granted pursuant to
the Plan, the  Company shall make  available to the  holder of  such
option, not later than one hundred twenty (120) days after the close
of each of the Company's fiscal  years during the option term,  upon
request, such financial and other information regarding the  Company
as comprises the annual  report to the  shareholders of the  Company
provided for in the bylaws of the Company.

         (d)  Nothing in  the Plan  or any  instrument executed  or
option granted  pursuant  thereto  shall confer  upon  any  eligible
participant or optionee any right to  continue in the employ of  the
Company or any Affiliate or shall affect the right of the Company or
any  Affiliate  to   terminate  the  employment   of  any   eligible
participant or optionee with or without cause.

    9.   ADJUSTMENTS UPON CHANGES IN COMMON STOCK.

         (a)  If any change is made in the Common Stock subject to

the Plan, or subject to any  option granted under the Plan  (through
merger,  consolidation,   reorganization,  recapitalization,   stock
dividend,  dividend  in  property  other  than  cash,  stock  split,
liquidating dividend,  combination of  shares, exchange  of  shares,
change  in  corporate   structure  or  otherwise),   the  Plan   and
outstanding options will be appropriately adjusted in the  class(es)
and the  maximum  number of  shares  subject  to the  Plan  and  the
class(es) and the  number of shares  and price per  share of  Common
Stock subject to outstanding options.

          (b)  Notwithstanding anything to the contrary in this Plan,
in the event of a Change  in Control (as hereinafter defined),  then,
to the extent permitted by applicable law:  (i) the time during which
options become vested shall automatically be accelerated so that  the
unvested portions of all options shall be vested prior to the  Change
in Control  and  (ii)  the  time during  which  the  options  may  be
exercised shall automatically be accelerated  to prior to the  Change
of Control.   Upon  or  after the  acceleration  of the  vesting  and
exercise periods, at the election of the holders of the options,  the
options may be:   (x)  exercised or,  if the  surviving or  acquiring
corporation agrees  to  assume  the  options  or  substitute  similar
options, (y)  assumed;  or  (z)  replaced  with  substitute  options.
Options not exercised, substituted  or assumed prior  to or upon  the
Change in Control shall be terminated.

          (c)  For purposes of the Plan, a "Change of Control"  shall
be deemed to have occurred at any of the following times:

               (i)  Upon  the  acquisition   (other  than  from   the
Company) by  any person,  entity or  "group," within  the meaning  of
Section 13(d) (3) or  14(d) (2) of the  Exchange Act (excluding,  for
this purpose, the Company or its affiliates, or any employee  benefit
plan of  the  Company or  its  affiliates which  acquires  beneficial
ownership  of  voting  securities  of  the  Company),  of  beneficial
ownership (within the  meaning of  Rule 13d-3  promulgated under  the
Exchange Act)  of fifty  percent (50%)  or more  of either  the  then
outstanding shares of Common  Stock or the  combined voting power  of
the Company's  then outstanding  voting securities  entitled to  vote
generally in the election of directors; or

               (ii) At the time  individuals who, as  of October  23,
1995, constitute  the Board  (the "Incumbent  Board") cease  for  any
reason to constitute at least a majority of the Board, provided  that
any person becoming a director subsequent to October 23, 1995,  whose
election, or nomination for  election by the Company's  stockholders,
was approved by a vote of at  least a majority of the directors  then
comprising the Incumbent Board (other than an election or  nomination
of an individual whose initial assumption of office is in  connection
with an  actual  or  threatened  election  contest  relating  to  the
election of the Directors of the  Company, as such terms are used  in
Rule 14A-11 of  Regulation 14A  promulgated under  the Exchange  Act)
shall be, for purposes of the Plan, considered as though such  person
were a member of the Incumbent Board; or

               (iii)     Immediately prior to the consummation by the

Company of a  reorganization, merger, consolidation,  (in each  case,
with respect  to  which persons  who  were the  stockholders  of  the
Company  immediately  prior   to  such   reorganization,  merger   or
consolidation do  not, immediately  thereafter, own  more than  fifty
percent (50%) of the combined voting power entitled to vote generally
in  the  election  of  directors   of  the  reorganized,  merged   or
consolidated company's  then  outstanding  voting  securities)  or  a
liquidation or dissolution of  the Company or of  the sale of all  or
substantially all of the assets of the Company; or

               (iv) The occurrence  of  any  other  event  which  the
Incumbent Board  in  its  sole discretion  determines  constitutes  a
Change of Control.


    10.  AMENDMENT OF THE PLAN.

         (a)  The Board at  any time,  and from time  to time,  may
amend the Plan.  However, except as provided in paragraph 9 relating
to adjustments upon changes in the Common Stock, no amendment  shall
be effective  unless approved  by the  stockholders of  the  Company
within twelve  (12)  months before  or  after the  adoption  of  the
amendment, where the amendment will:

              (i)   Increase  the  number  of  shares  reser ved  for
         options under the Plan;

              (ii)     Materially  modify  the  requirements  as  to
         eligibility for participation in the Plan; or

               (iii)  Materially  increase the benefits accruing  to
         participants under the Plan.

         (b)  It is expressly contemplated that the Board may amend
the Plan in any  respect the Board deems  necessary or advisable  to
provide optionees  with  the  maximum benefits  provided  or  to  be
provided under  the  provisions  of the  Code  and  the  regulations
promulgated thereunder relating to employee incentive stock  options
and/or to  bring  the Plan  and/or  options granted  under  it  into
compliance therewith.

         (c)  Rights  and  obligations  under  any  option  granted
before amendment of the Plan shall not be altered or impaired by any
amendment of the Plan, unless (i)  the Company requests the  consent
of the person to whom the  option was granted, and (ii) such  person
consents in writing.

    11.  TERMINATION OR SUSPENSION OF THE PLAN.

         (a)  The Board may  suspend or terminate  the Plan  at any
time.  Unless sooner terminated, the  Plan shall terminate on  March
16, 1994.  No options may be  granted under the Plan while the  Plan
is suspended or after it is terminated.

         (b)  Rights and obligations under any option granted while

the Plan is in effect shall not be altered or impaired by suspension
or termination of the Plan, except with the consent of the person to
whom the option was granted.

    12.  EFFECTIVE DATE OF PLAN.

         The Plan  shall  become  effective as  determined  by  the
Board.

                            EXHIBIT 10.21

                             AMGEN INC.

             AMENDED AND RESTATED 1988 STOCK OPTION PLAN


    1.   PURPOSE.
         (a)  The purpose of the Plan is to provide a means by which
selected  employees  and  directors   (if  declared  eligible   under
paragraph 4) of and consultants to Amgen Inc., a Delaware corporation
(the "Company"), and its Affiliates, as defined in subparagraph 1(b),
directly or  indirectly  through  trusts for  the  benefit  of  their
families, may  be  given an  opportunity  to purchase  stock  of  the
Company.
         (b)  The word "Affiliate"  as used  in the  Plan means  any
parent corporation or subsidiary corporation of the Company, as those
terms are defined in  Sections 424(e) and  (f), respectively, of  the
Internal Revenue Code of 1986, as amended (the "Code").
         (c)  The Company, by means of the Plan, seeks to retain the
services of persons now holding positions,  to secure and retain  the
services of persons capable of filling such positions, and to provide
incentives for such persons to exert maximum efforts for the  success
of the Company.
         (d)  The Company intends that the options  issued under the
Plan shall,  in the  discretion  of the  Board  of Directors  of  the
Company (the "Board") or any committee to which responsibility for
administration of the Plan has been delegated pursuant to subparagraph
2(c), be either incentive stock options as that term is used in Section
422 of the Code ("Incentive Stock  Options"),  or options  which  do not
qualify as Incentive Stock Options ("Nonqualified Stock Options").  All
options shall be separately designated Incentive Stock Options or 
Nonqualified Stock Options at the time of grant, and in such form  as
issued pursuant  to  paragraph  5,  and  a  separate  certificate  or
certificates shall be issued for shares purchased on exercise of each
type of option.  An option designated as a Nonqualified Stock  Option
shall not be treated as an Incentive Stock Option.
               The word  "Trust" as  used in  the Plan  shall mean  a
trust created for the benefit of  the employee or consultant, his  or
her spouse, or members of their immediate family.  The word  optionee
shall mean the person to whom  the option is granted or the  employee
or consultant for whose benefit the option is granted to a Trust,  as
the context shall require.

    2.   ADMINISTRATION.
         (a)  The Plan shall be administered by the Board unless and
until the Board delegates administration to a committee, as  provided
in subparagraph 2(c).
         (b)  The Board shall have the power, subject to, and within
the limitations of, the express provisions of the Plan:
              (1)  To determine  from  time  to  time which  of  the
persons eligible under the Plan shall be granted options; when and how
the option shall be granted; whether the option will be an Incentive

Stock Option or a Nonqualified Stock  Option; the provisions of  each
option granted (which need not be  identical), including the time  or
times during the term of each option within which all or portions  of
such option may be exercised; and  the number of shares for which  an
option shall be granted to each such person.
              (2)  To construe  and interpret  the Plan  and options
granted under  it,  and to  establish,  amend and  revoke  rules  and
regulations for its administration.   The Board,  in the exercise  of
this power, may correct any defect, omission or inconsistency in  the
Plan or in any  option agreement, in  a manner and  to the extent  it
shall deem necessary or expedient to make the Plan fully effective.
              (3)  To amend the Plan as provided in paragraph 11.
              (4)  Generally, to exercise such powers and to perform
such acts as the  Board deems necessary or  expedient to promote  the
best interests of the Company.
         (c)  The Board may delegate administration of the Plan to a
committee composed of not fewer than  three (3) members of the  Board
(the "Committee"), all  of the members  of which  Committee shall be
disinterested persons, if required and  as defined by the  provisions
of subparagraph 2(d).  If administration is delegated to a Committee,
the Committee shall  have, in connection  with the administration  of
the Plan, the  powers theretofore  possessed by  the Board,  subject,
however, to such resolutions, not inconsistent with the provisions of
the Plan, as  may be adopted  from time to  time by the  Board.   The
Board may abolish the Committee at  any time and revest in the  Board
the administration of the Plan.
         (d)  The term "disinterested person", as used in this Plan,
shall mean an  administrator of  the Plan,  whether a  member of  the
Board or of any Committee to which responsibility for  administration
of the Plan has  been delegated pursuant to  subparagraph 2(c):   (i)
who  is  not  at  the  time   he  or  she  exercises  discretion   in
administering the Plan eligible  and has not at  any time within  one
(1) year prior  thereto been eligible  for selection as  a person  to
whom stock  may  be allocated  or  to  whom stock  options  or  stock
appreciation rights may be granted pursuant to the Plan or any  other
plan  of  the  Company  or  any  of  its  Affiliates  entitling   the
participants  therein  to  acquire  stock,  stock  options  or  stock
appreciation rights of the Company or any of its Affiliates; or  (ii)
who is  otherwise  considered  to  be  a  "disinterested  person"  in
accordance with  the rules,  regulations  or interpretations  of  the
Securities and Exchange Commission.  Any such person shall  otherwise
comply with  the requirements  of Rule  16b-3 promulgated  under  the
Securities Exchange Act of 1934, as amended (the "Exchange Act"),  as
from time to time in effect.
         (e)  Any requirement that an administrator of the Plan be a
"disinterested person" shall not apply if the Board or the  Committee
expressly declares that such requirement shall not apply.

    3.   SHARES SUBJECT TO THE PLAN.
         (a)  Subject to the provisions  of paragraph 9  relating to
adjustments upon  changes  in  stock, the  stock  that  may  be  sold
pursuant to options granted  under the Plan shall  not exceed in  the
aggregate Thirty Six Million (36,000,000) shares of the Company's $.0001
par value common stock (the "Common Stock").   If any option granted
under the Plan shall for any reason expire or otherwise terminate without

having been exercised in full, the  Common Stock not purchased  under
such option shall again become available for the Plan.
         (b)  The Common Stock subject  to the Plan may  be unissued
shares or reacquired shares, bought on the market or otherwise.
         (c)  An  Incentive  Stock  Option  may  be  granted  to  an
eligible person  under the  Plan only  if the  aggregate fair  market
value (determined  as of  the times  the respective  Incentive  Stock
Options are  granted)  of the  Common  Stock with  respect  to  which
Incentive Stock Options are  exercisable for the  first time by  such
optionee during any calendar year under all such plans of the Company
and its  Affiliates  does not  exceed  one hundred  thousand  dollars
($100,000).  Should it be determined that any portion of an Incentive
Stock Option granted under the Plan does not qualify for treatment as
an Incentive Stock Option by reason  of exceeding such maximum,  such
option shall be considered a Nonqualified Stock Option to the extent,
but only to the extent, of such excess.  Should it be determined that
an entire option does not qualify for treatment as an Incentive Stock
Option,  such  option  shall,  in  its  entirety,  be  considered   a
Nonqualified Stock Option.

    4.   ELIGIBILITY.
         (a)  Incentive  Stock  Options  may  be  granted   only  to
employees of the Company or its Affiliates, and a director or officer
of the  Company shall  not be  eligible  to receive  Incentive  Stock
Options unless such director  or officer is also  an employee of  the
Company or any Affiliate.  Nonqualified Stock Options may be  granted
only  to  employees  of,  or  consultants  to,  the  Company  or  its
Affiliates (including directors  or officers  who so  qualify) or  to
Trusts of any such employee or consultant.
         (b)  A director  shall  in no  event  be eligible  for  the
benefits of  the Plan  unless and  until such  director is  expressly
declared eligible to participate in the  Plan by action of the  Board
or the Committee, and only if, at any time discretion is exercised by
the Board or the Committee in the selection of a director as a person
to whom options may be granted, or in the determination of the number
of shares which may be covered by options granted to a director:  (i)
a majority of  the Board and  a majority of  the directors acting  in
such matter  are disinterested  persons, as  defined in  subparagraph
2(d); (ii) the Committee  consists solely of "disinterested  persons"
as defined in subparagraph 2(d); or (iii) the Plan otherwise complies
with the requirements  of Rule 16b-3  promulgated under the  Exchange
Act, as  from time  to time  in effect.   The  Board shall  otherwise
comply with  the requirements  of Rule  16b-3 promulgated  under  the
Exchange Act, as from time to time in effect.
         (c)  No person  shall  be  eligible  for the  grant  of  an
Incentive Stock Option under the Plan if, at the time of grant,  such
person owns (or is  deemed to own pursuant  to Section 424(d) of  the
Code) stock  possessing more  than ten  percent  (10%) of  the  total
combined voting power of  all classes of stock  of the Company or  of
any of its  Affiliates unless the  exercise price  of such  Incentive
Stock Option is at  least one hundred and  ten percent (110%) of  the
fair market value of the  Common Stock at the  date of grant and  the
term of the  Incentive Stock Option  does not exceed  five (5)  years
from the date of grant.

    5.   OPTION PROVISIONS.
         Each option shall be  in suc h form and  shall contain such
terms and  conditions  as  the Board  or  the  Committee  shall  deem
appropriate.    The  provisions  of  separate  options  need  not  be
identical, but each  option shall include  (through incorporation  of
provisions hereof  by  reference  in the  option  or  otherwise)  the
substance of each of the following provisions:
         (a)  No option shall be exercisable after the expiration of
ten (10) years from the date it was granted.
         (b)  The exercise  price  of  each Incentive  Stock  Option
shall be not less than one hundred percent (100%) of the fair  market
value of  the Common  Stock subject  to the  option on  the date  the
option is granted.   The exercise  price of  each Nonqualified  Stock
Option shall be not less than  eighty-five percent (85%) of the  fair
market value of the  Common Stock subject to  the option on the  date
the option is granted.
         (c)  The purchase price  of Common Stock  acquired pursuant
to an option  shall be paid,  to the extent  permitted by  applicable
statutes and regulations, either:  (i) in cash at the time the option
is exercised;  or  (ii)  at  the  discretion  of  the  Board  or  the
Committee, either at the time of grant or exercise of the option  (A)
by delivery to the Company of other Common Stock of the Company,  (B)
according to  a  deferred payment  or  other arrangement  (which  may
include, without limiting the generality of the foregoing, the use of
other Common Stock of the Company) with the person to whom the option
is  granted  or  to  whom  the  option  is  transferred  pursuant  to
subparagraph 5(d), or (C)  in any other  form of legal  consideration
that may  be  acceptable to  the  Board  or the  Committee  in  their
discretion.
    In the case of any deferred payment arrangement,  interest shall
be payable at least  annually and shall be  charged at not less  than
the minimum  rate of  interest necessary  to avoid  the treatment  as
interest, under any applicable provisions of the Code, of any amounts
other than amounts stated to be  interest under the deferred  payment
arrangement.
         (d)  An  option  granted  to  a  natural  person  shall  be
exercisable during the lifetime of such  person only by such  person,
provided that such person during such person's lifetime may designate
a Trust to be such person's beneficiary with respect to any Incentive
Stock Options granted after February 25, 1992 and with respect to any
Nonqualified Stock  Options, and  such beneficiary  shall, after  the
death of the  person to  whom the option  was granted,  have all  the
rights that  such person  has while  living, including  the right  to
exercise the option.  In the  absence of such designation, after  the
death of the person to whom  the option is granted, the option  shall
be exercisable by the person or persons to whom the optionee's rights
under such  option  pass  by will  or  by  the laws  of  descent  and
distribution.
         (e)  The total number of shares of Common  Stock subject to
an option may,  but need not,  be allotted  in periodic  installments
(which may, but need not, be equal).   From time to time during  each
of such installment periods, the option may be exercised with respect
to some or  all of the  shares allotted to  that period, and/or  with
respect to some or all of the shares allotted to any prior period  as
to which the option was not fully exercised.  During the remainder of the
term of the option (if its term extends beyond the end of the installment

periods), the option may be exercised from time to time with  respect
to any shares then remaining subject  to the option.  The  provisions
of this  subparagraph  5(e)  are subject  to  any  option  provisions
governing the minimum number of shares  as to which an option may  be
exercised.
         (f)  The Company may require any optionee, or any person to
whom an option is transferred under subparagraph 5(d), as a condition
of exercising  any  such  option:  (1)  to  give  written  assurances
satisfactory to  the  Company  as to  the  optionee's  knowledge  and
experience in  financial  and business  matters  and/or to  employ  a
purchaser representative  who has  such knowledge  and experience  in
financial and business  matters, and  that he  or she  is capable  of
evaluating, alone or  together with  the purchaser's  representative,
the merits  and risks  of  exercising the  option;  and (2)  to  give
written assurances  satisfactory to  the  Company stating  that  such
person is acquiring the Common Stock  subject to the option for  such
person's own account and not with any present intention of selling or
otherwise distributing the Common Stock.  These requirements, and any
assurances given pursuant to such requirements, shall be  inoperative
if: (i) the issuance  of the shares upon  the exercise of the  option
has been  registered under  a then  currently effective  registration
statement  under  the  Securities  Act  of  1933,  as  amended   (the
"Securities Act");  or  (ii)  as to  any  particular  requirement,  a
determination  is  made  by  counsel   for  the  Company  that   such
requirement need  not be  met in  the  circumstances under  the  then
applicable securities law.
         (g)  An option  shall  terminate  three  (3)  months  after
termination  of  the  optionee's  employment  or  relationship  as  a
consultant with  the  Company  or  an  Affiliate,  unless:  (i)  such
termination is due to such  person's permanent and total  disability,
within the meaning of  Section 422(c)(6) of the  Code, in which  case
the option may, but need not, provide that it may be exercised at any
time within one (1) year following such termination of employment or
relationship as a  consultant; (ii) the  optionee dies  while in  the
employ of  or while  serving as  a consultant  to the  Company or  an
Affiliate, or within not more than three (3) months after termination
of such employment or relationship as a consultant, in which case the
option may, but  need not, provide  that it may  be exercised at  any
time within eighteen (18) months following the death of the  optionee
by the person  or persons to  whom the optionee's  rights under  such
option pass by will  or by the laws  of descent and distribution;  or
(iii) the option  by its  terms specifies  either (A)  that it  shall
terminate sooner  than  three (3)  months  after termination  of  the
optionee's employment or relationship as a consultant, or (B) that it
may be exercised more than three (3) months after termination of  the
optionee's employment  or  relationship  as  a  consultant  with  the
Company or  an  Affiliate.   This  subparagraph  5(g)  shall  not  be
construed to extend  the term of  any option or  to permit anyone  to
exercise the option  after expiration of  its term, nor  shall it  be
construed to increase the number of shares as to which any option  is
exercisable from the amount exercisable on the date of termination of
the optionee's employment or relationship as a consultant.
         (h)  The option  may,  but need  not,  include a  provision
whereby the optionee may elect at any time during the term of his  or
her employment or relationship  as a consultant  with the Company  or
any Affiliate to exercise the option as to any part or all of the shares

subject to the option prior to the stated vesting date of the  option
or of any installment or installments  specified in the option.   Any
shares so purchased from  any unvested installment  or option may  be
subject to a repurchase right in favor of the Company or to any other
restriction the Board or the Committee determines to be appropriate.
         (i)  To the extent provided by the terms of  an option, the
optionee may  satisfy any  federal, state  or local  tax  withholding
obligation relating to  the exercise  of such  option by  any of  the
following means or by  a combination of such  means: (1) tendering  a
cash payment; (2) authorizing the Company to withhold from the shares
of the Common Stock otherwise issuable to the participant as a result
of the exercise of the stock option a number of shares having a  fair
market value less than or equal to the amount of the withholding  tax
obligation; or (3) delivering to  the Company owned and  unencumbered
shares of the Common  Stock having a fair  market value less than  or
equal to the amount of the withholding tax obligation.
         (j)  Without in any way limiting the authority of the Board
or Committee to make or not to make grants of Options hereunder,  the
Board or Committee shall have the  authority (but not an  obligation)
to include  as part  of any  Option  agreement, and  all  outstanding
Nonqualified Stock Options, to the extent there are unvested  options
on June 30, 1991, shall be amended to include, a provision  entitling
the optionee to a  further Option (a "Re-Load  Option") in the  event
the optionee exercises the Option evidenced by the Option  agreement,
in whole or in part, by surrendering other shares of Common Stock  in
accordance with this Plan and the terms and conditions of the  Option
agreement.  Any  such Re-Load  Option (i) shall  be for  a number  of
shares equal to the  number of shares surrendered  as part or all  of
the exercise price of  such Option (or  surrendered for shares  which
were unvested on June 30, 1991 in the case of an amended Nonqualified
Stock Option); (ii) shall have an  expiration date which is the  same
as the expiration date of the Option the exercise of which gave  rise
to such Re-Load Option; (iii) shall  have an exercise price which  is
equal to one hundred percent (100%)  of the fair market value of  the
Common Stock subject to the Re-Load Option on the date of exercise of
the original Option or, in the case  of a Re-Load Option which is  an
Incentive Stock Option and which is granted to a 10% stockholder  (as
defined in subparagraph 4(c)), shall have an exercise price which  is
equal to one hundred and ten percent (110%) of the fair market  value
of the Common  Stock subject  to the Re-Load  Option on  the date  of
exercise of the original Option; and (iv) shall be granted under this
Plan, if sufficient shares are  available under subparagraph 3(a)  of
the Plan,  and  if sufficient  shares  of  Common Stock  are  not  so
available, shall be granted under the  1991 Equity Incentive Plan  to
the extent shares of Common Stock are available under that Plan.
    Any such Re-Load Option  may be an Incentive  Stock Option or  a
Nonqualified Stock Option, as the Board or Committee may designate at
the time of the grant of the original Option, except that all Re-Load
Options on unvested  shares (as of  June 30,  1991) of  Non-Qualified
Stock Options shall be Nonqualified Stock Options, provided, however,
that the  designation of  any Re-Load  Option as  an Incentive  Stock
Option  shall  be  subject  to  the  one  hundred  thousand   dollars
($100,000) annual  limitation on  exercisability of  Incentive  Stock
Options described in subparagraph 3(c) of the Plan and in Section 422(d)

of the Code.   There shall be no Re-Load Options on a Re-Load  Option.
Any such  Re-Load Option  shall be  subject  to the  availability  of
sufficient shares under subparagraph 3(a) of  this Plan or under  the
1991 Equity Incentive Plan and shall  be subject to such other  terms
and conditions as the Board or Committee may determine.

    6.   COVENANTS OF THE COMPANY.
         (a)  During the  terms  of the  options  granted under  the
Plan, the Company  shall keep available  at all times  the number  of
shares of stock required to satisfy such options.
         (b)  The Company shall seek to obtain  from each regulatory
commission or agency having jurisdiction over the Plan such authority
as may be required to issue and sell shares of stock upon exercise of
the options  granted under  the Plan;  provided, however,  that  this
undertaking shall  not  require the  Company  to register  under  the
Securities Act either the Plan, any option granted under the Plan  or
any Common Stock issued or issuable pursuant to any such option.  If,
after reasonable efforts, the  Company is unable  to obtain from  any
such regulatory commission or agency the authority which counsel  for
the Company deems necessary for the lawful issuance and sale of stock
under the Plan, the Company shall be relieved from any liability  for
failure to issue and sell stock upon exercise of such options  unless
and until such authority is obtained.

    7.   USE OF PROCEEDS FROM STOCK.
         Proceeds from the sale of Common Stock pursuant  to options
granted under the Plan shall constitute general funds of the Company.

    8.   MISCELLANEOUS.
         (a)  The Board or  the Committee  shall have  the power  to
accelerate the time during  which an option may  be exercised or  the
time during which an option or any part thereof will vest pursuant to
subparagraph 5(e),  notwithstanding  the  provisions  in  the  option
stating the time during which it may be exercised or the time  during
which it will vest.   Each option providing  for vesting pursuant  to
subparagraph  5(e)  shall  also  provide  that  if  the  employee  or
consultant should die during the term  of his or her employment  with
the Company  or  his  or  her  affiliation  with  the  Company  as  a
consultant, the vesting schedule of options granted to such  employee
or consultant or to the Trusts  of such employee or consultant  shall
be accelerated by twelve months for  each full year the employee  has
been employed  by or  the consultant  has  been affiliated  with  the
Company.   Options granted  under the  Plan that  are outstanding  on
February 25,  1992,  shall  be amended  to  include  the  accelerated
vesting provided  for in  the preceding  sentence of  this  Paragraph
8(a).
         (b)  Neither an optionee nor  any person to whom  an option
is transferred  under subparagraph  5(d) shall  be deemed  to be  the
holder of, or to have any of the rights of a holder with respect  to,
any shares subject to  such option unless and  until such person  has
satisfied all requirements for exercise of the option pursuant to its
terms.
         (c)  Throughout the term of any option  granted pursuant to
the Plan, the  Company shall  make available  to the  holder of  such
option, not later than one hundred twenty (120) days after the close

of each of the  Company's fiscal years during  the option term,  upon
request, such financial and  other information regarding the Company
as comprises the  annual report to  the shareholders of the  Company
provided for in the bylaws of the Company.
         (d)  Nothing in  the  Plan or  any  instrument executed  or
option granted  pursuant  thereto  shall  confer  upon  any  eligible
participant or optionee any  right to continue in  the employ of  the
Company or any  Affiliate or to  continue acting as  a consultant or
shall affect the right of the  Company or any Affiliate to  terminate
the employment or consulting relationship of any eligible participant
or optionee with or without cause.  In the event that an optionee  is
permitted or  otherwise entitled  to take  a  leave of  absence,  the
Company shall have the unilateral right to (i) determine whether such
leave of absence will  be treated as a  termination of employment  or
relationship as consultant for purposes of paragraph 5(g) hereof  and
corresponding provisions of any outstanding options, and (ii) suspend
or otherwise delay the time or  times at which the shares subject  to
the option would otherwise vest.

    9.   CANCELLATION AND RE-GRANT OF OPTIONS.
         The Board  or the  Committee shall  have  the authority  to
effect, at any time and  from time to time,  with the consent of  the
affected option holders, (i) the repricing of any or all  outstanding
options under the  Plan and/or (ii)  the cancellation of  any or  all
outstanding options  under the  Plan and  the grant  in  substitution
therefor new options under  the Plan covering  the same or  different
numbers of shares  of Common  Stock but  having an  option price  per
share not  less than  eighty-five percent  (85%) of  the fair  market
value in the case of a Nonqualified Stock Option, one hundred percent
(100%) of the  fair market value  in the case  of an Incentive  Stock
Option  or,  in  the  case  of  a  10%  stockholder  (as  defined  in
subparagraph 4(c)), not less than one hundred and ten percent  (110%)
of the fair market value per share  of Common Stock on the new  grant
date.

    10.  ADJUSTMENTS UPON CHANGES IN COMMON STOCK.
         (a)  If any chang e is made in  the Common Stock subject  to
the Plan, or subject  to any option granted  under the Plan  (through
merger,  consolidation,   reorganization,   recapitalization,   stock
dividend,  dividend  in  property  other  than  cash,  stock   split,
liquidating dividend,  combination  of shares,  exchange  of  shares,
change in corporate structure or otherwise), the Plan and outstanding
options will  be  appropriately adjusted  in  the class(es)  and  the
maximum number of shares  subject to the Plan  and the class(es)  and
the number of shares and price  per share of Common Stock subject  to
outstanding options.
          (b)  Notwithstanding anything to the contrary in this Plan,
in the event of a Change  in Control (as hereinafter defined),  then,
to the extent permitted by applicable law:  (i) the time during which
options become vested shall automatically be accelerated so that  the
unvested portions of all options shall be vested prior to the  Change
in Control  and  (ii)  the  time during  which  the  options  may  be
exercised shall automatically be accelerated  to prior to the  Change
of Control.   Upon or after the acceleration of the vesting and exercise
periods, at the election of the holders of the options, the options may

be: (x) exercised or, if the surviving or acquiring corporation agrees
to assume the options or substitute similar options, (y) assumed; or (z)
replaced with substitute options.  Options not exercised, substituted
or  assumed  prior  to  or  upon  the  Change  in  Control  shall  be
terminated.
          (c)  For purposes of the Plan, a "Change of Control" shall
be deemed to have occurred at any of the following times:
               (i)  Upon  the  acquisition   (other  than  from   the
Company) by  any person,  entity or  "group," within  the meaning  of
Section 13(d) (3) or  14(d) (2) of the  Exchange Act (excluding,  for
this purpose, the Company or its affiliates, or any employee  benefit
plan of  the  Company or  its  affiliates which  acquires  beneficial
ownership  of  voting  securities  of  the  Company),  of  beneficial
ownership (within the  meaning of  Rule 13d-3  promulgated under  the
Exchange Act)  of fifty  percent (50%)  or more  of either  the  then
outstanding shares of Common  Stock or the  combined voting power  of
the Company's  then outstanding  voting securities  entitled to  vote
generally in the election of directors; or
               (ii) At the  time individuals  who, as  ofOctober  23,
1995, constitute  the Board  (the "Incumbent  Board") cease  for  any
reason to constitute at least a majority of the Board, provided  that
any person becoming a director subsequent to October 23, 1995,  whose
election, or nomination for  election by the Company's  stockholders,
was approved by a vote of at  least a majority of the directors  then
comprising the Incumbent Board (other than an election or  nomination
of an individual whose initial assumption of office is in  connection
with an  actual  or  threatened  election  contest  relating  to  the
election of the Directors of the  Company, as such terms are used  in
Rule 14A-11 of  Regulation 14A  promulgated under  the Exchange  Act)
shall be, for purposes of the Plan, considered as though such  person
were a member of the Incumbent Board; or
               (iii)     Immediately prior to the consummation by the
Company of a  reorganization, merger, consolidation,  (in each  case,
with respect  to  which persons  who  were the  stockholders  of  the
Company  immediately  prior   to  such   reorganization,  merger   or
consolidation do  not, immediately  thereafter, own  more than  fifty
percent (50%) of the combined voting power entitled to vote generally
in  the  election  of  directors   of  the  reorganized,  merged   or
consolidated company's  then  outstanding  voting  securities)  or  a
liquidation or dissolution of  the Company or of  the sale of all  or
substantially all of the assets of the Company; or
              (iv) The occurrence  of  any  other  event  which  the
Incumbent Board  in  its  sole discretion  determines  constitutes  a
Change of Control.

    11.  QUALIFIED DOMESTIC RELATIONS ORDERS
          (a)  Anything in the Plan to the contrary  notwithstanding,
rights under options  may be assigned  to an Alternate  Payee to  the
extent that a  QDRO so provides.   (The terms  "Alternate Payee"  and
"QDRO" are defined in  Subsection (c) below.)   The assignment of  an
option to an Alternate Payee pursuant to a QDRO shall not be  treated
as having caused  a new grant.   The transfer  of an Incentive  Stock
Option to  an Alternate  Payee  may, however,  cause  it to  fail  to
qualify as an Incentive Stock Option.  If an option is assigned to an
Alternate Payee, the Alternate Payee generally has the same rights as

the grantee under the terms of  the Plan; provided however, that  (1)
the option shall be  subject to the same  vesting terms and  exercise
period as  if the  option were  still  held by  the grantee,  (2)  an
Alternate Payee may not transfer an option and (3) an Alternate Payee
is ineligible for Re-Load Options.
          (b)  In the event of the Plan administrator's receipt of  a
domestic relations  order or  other notice  of  adverse claim  by  an
Alternate Payee of a grantee of  an option, transfer of the  proceeds
of the exercise of such option, whether in the form of cash, stock or
other property, may be suspended.  Such proceeds shall thereafter  be
transferred pursuant  to  the terms  of  a QDRO  or  other  agreement
between the  grantee and  Alternate Payee.   A  grantee's ability  to
exercise an option may be barred if the Plan administrator receives a
court order directing the Plan administrator not to permit exercise.
          (c)  The word "QDRO" as used in the Plan shall mean a court
order (1) that creates or recognizes the right of the spouse,  former
spouse or  child  (an "Alternate  Payee")  of an  individual  who  is
granted an option to an interest  in such option relating to  marital
property rights or support obligations and (2) that the administrator
of the  Plan  determines would  be  a "qualified  domestic  relations
order," as that  term is defined  in section 414(p)  of the Code  and
section  206(d)  of  the  Employee  Retirement  Income  Security  Act
("ERISA"), but for the fact that the Plan is not a plan described  in
section 3(3) of ERISA.

    12.  AMENDMENT OF THE PLAN.
         (a)  The Board  at any  time, and  from time  to time,  may
amend the Plan.  However, except as provided in paragraph 10 relating
to adjustments upon changes in the  Common Stock, no amendment  shall
be effective  unless  approved by  the  stockholders of  the  Company
within twelve  (12)  months  before or  after  the  adoption  of  the
amendment, where the amendment will:
              (i)   Increase  the  number  of  shares  reserved  for
options under the Plan;
              (ii)  Modify  the requirements  as to  eligibility for
participation in the Plan (to  the extent such modification  requires
stockholder  approval  in   order  for  the   Plan  to  satisfy   the
requirements of Section  422(b) of  the Code  or to  comply with  the
requirements of Rule 16b-3 promulgated under the Exchange Act); or
              (iii) Modify  the  Plan  in  any  other  way  if  such
modification requires stockholder approval in  order for the Plan  to
satisfy the requirements of Section 422(b)  of the Code or to  comply
with the requirements  of Rule 16b-3  promulgated under the  Exchange
Act.
         (b)  It is expressly contemplated that the  Board may amend
the Plan in  any respect the  Board deems necessary  or advisable  to
provide optionees  with  the  maximum  benefits  provided  or  to  be
provided under  the  provisions  of  the  Code  and  the  regulations
promulgated thereunder relating to  employee incentive stock  options
and/or to  bring  the  Plan and/or  options  granted  under  it  into
compliance therewith.
         (c)  Rights and obligations under any option granted before
amendment of  the  Plan shall  not  be  altered or  impaired  by  any
amendment of the Plan, unless:  (i) the Company requests the consent

of the person to whom the option was granted; and (ii) such person
consents in writing.

    13.  TERMINATION OR SUSPENSION OF THE PLAN.
         (a)  The Board may  suspend or  terminate the  Plan at  any
time.  Unless sooner  terminated, the Plan  shall terminate on  March
14, 1998.  No options may be granted under the Plan while the Plan is
suspended or after it is terminated.
         (b)  Rights and obligations under any option  granted while
the Plan is in effect shall not be altered or impaired by  suspension
or termination of the Plan, except with the consent of the person  to
whom the option was granted.

    14.  EFFECTIVE DATE OF PLAN.
         The Plan shall become effective as determined by the Board.
No option granted  as the result  of the amendment  on April 2,  1991
shall be exercisable unless and until  said amendment is approved  by
the stockholders  of  the Company,  and  to the  extent  required  or
necessary under  applicable law,  amendments made  on April  2,  1991
shall not  be effective  until approved  by the  stockholders of  the
Company.
 

5 1,000,000 9-MOS DEC-31-1995 SEP-30-1995 145 847 205 0 86 1420 708 64 2348 596 0 0 0 0 1575 2348 1334 1426 207 881 0 0 11 581 189 0 0 0 0 392 1.40 1.38