UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON D.C. 20549
                                   FORM 10-K/A
                                 Amendment No. 1         
     (Mark One)
     [ X ]     ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE 
               SECURITIES EXCHANGE ACT OF 1934
     For the fiscal year ended December 31, 1997
               OR
     [   ]    TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE 
               SECURITIES EXCHANGE ACT OF 1934
     Commission file number 0-12477

                                   AMGEN INC.
             (Exact name of registrant as specified in its charter)
             Delaware                                       95-3540776
      (State or other jurisdiction of                    (I.R.S. Employer
      incorporation or organization)                    Identification No.)

     One Amgen Center Drive, Thousand Oaks, California           91320-1789
      (Address of principal executive offices)                   (Zip Code)

     Registrant's telephone number, including area code:       805-447-1000

          Securities registered pursuant to Section 12(g) of the Act:
         Common stock, $.0001 par value, Common shares purchase rights,
                     Contractual contingent payment rights
                                (Title of class)

     Indicate by  check  mark whether  the  registrant (1)  has  filed  all
     reports required to be filed by Section 13 or 15(d) of the  Securities
     Exchange Act of  1934 during  the preceding 12  months   (or for  such
     shorter period that the registrant was required to file such reports),
     and (2) has been subject to  such filing requirements for the past  90
     days.     Yes  X  No
     Indicate by check mark if disclosure of delinquent filers pursuant  to
     Item 405 of Regulation  S-K is not contained  herein, and will not  be
     contained, to the best of registrant's knowledge, in definitive  proxy
     or information statements  incorporated by  reference in  Part III  of
     this Form 10-K or any amendment to this Form 10-K. [X]

     The approximate aggregate market value of voting and non-voting  stock
     held by non-affiliates  of the  registrant was  $13,380,017,000 as  of
     February 28, 1998 (A)
                                     255,754,703
     (Number of shares of common stock outstanding as of February 28, 1998)

     Documents incorporated by reference:
                     Document                             Form 10-K Parts
     Definitive 1998 Proxy Statement, to be filed within
     120 days of December 31, 1997 (specified portions)          III

     (A) Excludes 3,895,561 shares  of common stock  held by directors  and
       officers, and any stockholders whose ownership exceeds five  percent
       of  the shares  outstanding, at  February 28,  1998.   Exclusion  of
       shares held by any person  should not be construed to indicate  that
       such person possesses  the power, directly or indirectly, to  direct
       or  cause  the  direction of  the  management  or  policies  of  the
     

       registrant, or  that such person  is controlled by  or under  common
       control with the registrant.
     

                             EXPLANATORY STATEMENT

          This Amendment No. 1 to the Annual Report on Form 10-K  for Amgen
     Inc. (the "Company") for  the  fiscal year ended  December 31, 1997 is
     being filed to amend Item 14 (a) (3)  by adding as  Exhibits,  certain
     amended and restated financial data schedules.

          As reported in the Company's Annual Report on  Form  10-K for the
     fiscal  year  ended  December  31, 1997 (the "Initial Form 10-K"), the
     Company adopted  Statement of Financial Accounting Standards  ("SFAS")
     No. 128, "Earning  Per  Share," which required a retroactive change in
     the method used to compute and display earnings per share information.
     Although earnings per share information presented in the  Initial Form
     10-K for prior periods was restated to the new method, financial  data
     schedules for prior periods, restated in accordance with SFAS No. 128,
     were not included.  Such restated  financial data  schedules are filed
     pursuant to this Amendment No. 1.  This Amendment No. 1  is also being
     filed  to  amend  certain  amounts  in  the  restated  financial  data
     schedules,  as footnoted,  to properly  state  information required by
     Regulation S-K,  Item 601 (c), Appendix A.  In addition, the financial
     data  schedule  filed  as an  exhibit to the Initial Form 10-K is also
     being  amended,  as  footnoted,  to  properly  state  certain  amounts
     required  by  Regulation  S-K,  Item 601 (c),  Appendix  A  and  filed
     pursuant to this Amendment No. 1.  
                                            2













     
                                             PART IV

     Item 14.  EXHIBITS, FINANCIAL STATEMENT SCHEDULES AND REPORTS ON FORM 
               8-K


       (a)3.   Exhibits

     Exhibit No.                     Description

       3.1       Restated Certificate of Incorporation as amended. (19)
       3.2*      Amended and Restated Bylaws.
       4.1       Indenture dated January  1, 1992 between the Company  and
                 Citibank N.A., as trustee. (8)
       4.2       Forms of Commercial Paper Master Note Certificates. (10)
       4.3       First Supplement  to Indenture, dated  February 26,  1997
                 between the Company and Citibank N.A., as trustee. (16)
       4.4       Officer's Certificate  pursuant to Sections  2.1 and  2.3
                 of the Indenture, as supplemented, establishing a  series
                 of  securities "8-1/8%  Debentures  due April  1,  2097."
                 (18)
       4.5       8-1/8% Debentures due April 1, 2097. (18)
       4.6       Form  of stock  certificate  for the  common  stock,  par
                 value $.0001 of the Company. (19)
       4.7       Officer's Certificate  pursuant to Sections  2.1 and  2.3
                 of  the  Indenture,  dated as  of  January  1,  1992,  as
                 supplemented by  the First supplemental Indenture,  dated
                 as of  February 26, 1997,  each between  the Company  and
                 Citibank,  N.A., as  Trustee,  establishing a  series  of
                 securities entitled "6.50%  Notes Due December 1,  2007".
                 (22)
       4.8       6.50% Notes  Due December  1, 2007  described in  Exhibit
                 4.7. (22)
      10.1*+     Company's  Amended  and Restated  1991  Equity  Incentive
                 Plan.
      10.2+      Company's Amended  and Restated 1984  Stock Option  Plan.
                 (14)
      10.3       Shareholder's Agreement  of Kirin-Amgen, Inc., dated  May
                 11, 1984, between the Company and Kirin Brewery  Company,
                 Limited  (with certain  confidential information  deleted
                 therefrom). (1)
      10.4       Amendment Nos.  1, 2, and 3,  dated March 19, 1985,  July
                 29,  1985 and  December 19,  1985, respectively,  to  the
                 Shareholder's Agreement  of Kirin-Amgen, Inc., dated  May
                 11, 1984  (with certain confidential information  deleted
                 therefrom). (3)
      10.5       Product License Agreement, dated September 30, 1985,  and
                 Technology License  Agreement, dated, September 30,  1985
                 between the Company and Ortho Pharmaceutical  Corporation
                 (with    certain   confidential    information    deleted
                 therefrom). (2)
      10.6       Product License Agreement, dated September 30, 1985,  and
                 Technology License  Agreement, dated  September 30,  1985
                 between  Kirin-Amgen,   Inc.  and  Ortho   Pharmaceutical
                 Corporation   (with  certain   confidential   information
                 deleted therefrom). (3)
      10.7+      Company's Amended  and Restated  Employee Stock  Purchase
                 Plan. (14)
                                       3
     
      10.8       Research, Development  Technology Disclosure and  License
                 Agreement PPO,  dated January  20, 1986,  by and  between
                 the Company and Kirin Brewery Co., Ltd. (4)
      10.9       Amendment  Nos.   4  and  5,   dated  October  16,   1986
                 (effective July 1, 1986) and December 6, 1986  (effective
                 July  1,   1986),  respectively,   to  the   Shareholders
                 Agreement of Kirin-Amgen,  Inc. dated May 11, 1984  (with
                 certain confidential information deleted therefrom). (5)
      10.10      Assignment  and  License  Agreement,  dated  October  16,
                 1986,  between the  Company and  Kirin-Amgen, Inc.  (with
                 certain confidential information deleted therefrom). (5)
      10.11      G-CSF  European  License Agreement,  dated  December  30,
                 1986,  between Kirin-Amgen,  Inc. and  the Company  (with
                 certain confidential information deleted therefrom). (5)
      10.12      Research  and   Development  Technology  Disclosure   and
                 License Agreement: GM-CSF, dated March 31, 1987,  between
                 Kirin  Brewery Company,  Limited  and the  Company  (with
                 certain confidential information deleted therefrom). (5)
      10.13+     Company's Amended  and Restated 1988  Stock Option  Plan.
                 (14)
      10.14+     Company's  Amended and  Restated Retirement  and  Savings
                 Plan. (14)
      10.15      Amendment,   dated   June   30,   1988,   to    Research,
                 Development,    Technology   Disclosure    and    License
                 Agreement:  GM-CSF dated  March 31, 1987,  between  Kirin
                 Brewery Company, Limited and the Company. (6)
      10.16      Agreement on G-CSF  in the EU, dated September 26,  1988,
                 between  Amgen  Inc.  and  F.  Hoffmann-La  Roche  &  Co.
                 Limited  Company (with  certain confidential  information
                 deleted therefrom). (7)
      10.17      Supplementary  Agreement to  Agreement dated  January  4,
                 1989 to  Agreement on G-CSF  in the  EU, dated  September
                 26, 1988, between the Company and F. Hoffmann-La Roche  &
                 Co.   Limited   Company,   (with   certain   confidential
                 information deleted therefrom). (7)
      10.18      Agreement on G-CSF  in Certain European Countries,  dated
                 January 1,  1989, between Amgen  Inc. and F.  Hoffmann-La
                 Roche &  Co. Limited Company  (with certain  confidential
                 information deleted therefrom). (7)
      10.19      Partnership  Purchase Agreement,  dated March  12,  1993,
                 between  the  Company,  Amgen  Clinical  Partners,  L.P.,
                 Amgen  Development  Corporation,  the  Class  A   limited
                 partners and the Class B limited partner. (9)
      10.20+     Amgen Supplemental  Retirement Plan dated  June 1,  1993.
                 (11)
      10.21      Promissory Note  of Mr. Kevin  W. Sharer,  dated June  4,
                 1993. (11)
      10.22+     Amgen Performance Based Management Incentive Plan. (17)
      10.23      Credit Agreement, dated as of June 23, 1995, among  Amgen
                 Inc.,  the  Borrowing  Subsidiaries  named  therein,  the
                 Banks named therein, Swiss Bank Corporation and ABN  AMRO
                 Bank N.V., as Issuing Banks, and Swiss Bank  Corporation,
                 as Administrative Agent. (12)
      10.24      Promissory  Note  of   Mr.  George  A.  Vandeman,   dated
                 December 15, 1995. (13)
      10.25      Promissory  Note  of   Mr.  George  A.  Vandeman,   dated
                 December 15, 1995. (13)
      10.26      Promissory  Note of  Mr.  Stan Benson,  dated  March  19,
                                       4
     
                 1996. (13)      
      10.27+     Amendment No.  1 to  the Company's  Amended and  Restated
                 Retirement and Savings Plan. (14)
      10.28+     Amendment Number 5 to the Company's Amended and  Restated
                 Retirement and Savings Plan dated January 1, 1993. (17)
      10.29+     Amendment Number 2 to the Company's Amended and  Restated
                 Retirement and Savings Plan dated April 1, 1996. (17)
      10.30      First  Amendment  to   Credit  Agreement,  dated  as   of
                 December 12,  1996,  among  Amgen  Inc.,  the   Borrowing
                 Subsidiaries named  therein, and  Swiss Bank  Corporation
                 as Administrative Agent. (17)
      10.31      Fourth Amendment to Rights Agreement, dated February  18,
                 1997 between Amgen  Inc. and American Stock Transfer  and
                 Trust Company, Rights Agent. (15)
      10.32      Preferred  Share  Rights Agreement,  dated  February  18,
                 1997, between Amgen Inc. and American Stock Transfer  and
                 Trust Company, Rights Agent. (15)
      10.33+     Consulting Agreement,  dated November  15, 1996,  between
                 the Company and Daniel Vapnek. (17)
      10.34+     Agreement, dated  May 30, 1995,  between the Company  and
                 George A. Vandeman. (17)
      10.35+     First  Amendment,  effective  January  1,  1998,  to  the
                 Company's Amended  and Restated  Employee Stock  Purchase
                 Plan. (20)
      10.36+     Third  Amendment,  effective  January  1,  1997,  to  the
                 Company's  Amended and  Restated Retirement  and  Savings
                 Plan dated April 1, 1996. (20)      
      10.37      Heads  of Agreement  dated April  10, 1997,  between  the
                 Company and  Kirin Amgen, Inc., on  the one hand, and  F.
                 Hoffmann-La Roche  Ltd, on the  other hand (with  certain
                 confidential information deleted therefrom). (20)
      10.38      Binding  Term  Sheet,  dated  August  20,  1997,  between
                 Guilford Pharmaceuticals  Inc. ("Guilford")  and GPI  NIL
                 Holdings,   Inc.,   and   Amgen   Inc.   (with    certain
                 confidential information deleted therefrom). (21)
      10.39*     Promissory Note  of Ms. Kathryn  E. Falberg, dated  April
                 7, 1995.
      10.40*     Promissory Note of Mr. Edward F. Garnett, dated July  18,
                 1997.
      10.41*+    Fourth Amendment  to the Company's  Amended and  Restated
                 Retirement  and  Savings Plan  as  amended  and  restated
                 effective April 1, 1996.
      10.42*+    Fifth  Amendment to  the Company's  Amended and  Restated
                 Retirement  and  Savings Plan  as  amended  and  restated
                 effective April 1, 1996.
      21*        Subsidiaries of the Company.
      23*        Consent of Ernst & Young LLP, Independent Auditors.   
      24*        Power of  Attorney.  
      27**       Amended - Financial  Data  Schedule  for  the  Year Ended
                 December 31, 1997.
      27.1**     Amended and restated - Financial  Data  Schedule  for the
                 Year  Ended  December 31, 1996;  and for  the Year  Ended
                 December 31, 1995. 
                                       5



     
      27.2**     Amended and restated - Financial  Data  Schedule  for the
                 Nine Months Ended September 30, 1997;  for the Six Months
                 Ended June 30, 1997; and for the Three Months Ended March
                 31, 1997.  
      27.3**     Amended  and  restated - Financial Data  Schedule for the
                 Nine Months Ended September 30, 1996;  for the Six Months
                 Ended June 30, 1996; and for the Three Months Ended March
                 31, 1996.
                 
     ----------------
     ** Filed herewith.
     +  Management contract or compensatory plan or arrangement.
     *  Previously filed as part of the Registrant's initial Annual Report
        on Form 10-K filed with the Commission on March 24, 1998.

     (1)  Filed as an exhibit  to the Annual Report  on Form 10-K for  the
          year ended  March 31,  1984 on  June 26,  1984 and  incorporated
          herein by reference.
     (2)  Filed as an  exhibit to Quarterly  Report on Form  10-Q for  the
          quarter ended  September  30,  1985 on  November  14,  1985  and
          incorporated herein by reference.
     (3)  Filed as an  exhibit to Quarterly  Report on Form  10-Q for  the
          quarter  ended  December  31,  1985  on  February  3,  1986  and
          incorporated herein by reference.
     (4)  Filed as an exhibit to Amendment No. 1 to Form S-1  Registration
          Statement (Registration  No.  33-3069)  on March  11,  1986  and
          incorporated herein by reference.
     (5)  Filed as an exhibit to the Form 10-K Annual Report for the  year
          ended March 31, 1987 on May 18, 1987 and incorporated herein  by
          reference.
     (6)  Filed as an exhibit to Form  8 amending the Quarterly Report  on
          Form 10-Q for the quarter ended June 30, 1988 on August 25, 1988
          and incorporated herein by reference.
     (7)  Filed as an exhibit  to the Annual Report  on Form 10-K for  the
          year ended  March 31,  1989 on  June 28,  1989 and  incorporated
          herein by reference.
     (8)  Filed as an  exhibit to  Form S-3  Registration Statement  dated
          December 19, 1991 and incorporated herein by reference.
     (9)  Filed as an  exhibit to the  Form 8-A dated  March 31, 1993  and
          incorporated herein by reference.
     (10) Filed as an exhibit to the Form 10-Q for the quarter ended March
          31, 1993 on May 17, 1993 and incorporated herein by reference.  
     (11) Filed as  an exhibit  to the  Form 10-Q  for the  quarter  ended
          September 30, 1993 on November 12, 1993 and incorporated  herein
          by reference.
     (12) Filed as  an exhibit  to the  Form 10-Q  for the  quarter  ended
          June 30, 1995  on August  11, 1995  and incorporated  herein  by
          reference.
     (13) Filed as an exhibit  to the Annual Report  on Form 10-K for  the
          year ended December 31, 1995 on March 29, 1996 and  incorporated
          herein by reference.
     (14) Filed as  an exhibit  to the  Form 10-Q  for the  quarter  ended
          September 30, 1996 on November  5, 1996 and incorporated  herein
          by reference.
     (15) Filed as  an  exhibit  to the  Form  8-K  Current  Report  dated
          February 18, 1997 on February  28, 1997 and incorporated  herein
          by reference.
     (16) Filed as an exhibit to the  Form 8-K Current Report dated  March
          14, 1997 on March 14, 1997 and incorporated herein by reference.
     (17) Filed as an exhibit  to the Annual Report  on Form 10-K for  the
          year ended December 31, 1996 on March 24, 1997 and  incorporated
          herein by reference.
                                       6  
     
     (18) Filed as an exhibit to the  Form 8-K Current Report dated  April
          8, 1997 on April 8, 1997 and incorporated herein by reference.
     (19) Filed as an exhibit to the Form 10-Q for the quarter ended March
          31, 1997 on May 13, 1997 and incorporated herein by reference.
     (20) Filed as an exhibit to the Form 10-Q for the quarter ended  June
          30,  1997  on  August  12,  1997  and  incorporated  herein   by
          reference.
     (21) Filed as exhibit 10.47 to the  Guilford Form 8-K Current  Report
          dated August  20, 1997  on September  4, 1997  and  incorporated
          herein by reference.
     (22) Filed as an  exhibit to the  Form 8-K Current  Report dated  and
          filed on December 5, 1997 and incorporated herein by reference.
                                       7
                                 

                                     SIGNATURES


          Pursuant to the  requirements of the  Securities Exchange Act  of
     1934, the registrant has duly caused  this Annual Report to be  signed
     on its behalf by the undersigned, thereunto duly authorized.


                                                  Amgen Inc.
                                                  (Registrant)



     Date:       5/8/98                   By:     /s/ KATHRYN E. FALBERG
                                                  Kathryn E. Falberg
                                                  Vice President, Finance,
                                                  Chief Financial Officer
                                                  and Chief Accounting
                                                  Officer



















     

 

5 1,000,000 YEAR DEC-31-1997 DEC-31-1997 239 787 283 14 109 1,544 1,669 483 3,110 742 229 0 0 0 2,139 3,110 2,220 2,401 301 301 1,308 0 4 861 217 0 0 0 0 644 2.44 2.35 Amended to conform with the requirements of Regulation S-K, Item 601 (c), Appendix A.
 

5 1,000,000 YEAR YEAR DEC-31-1996 DEC-31-1995 JAN-01-1996 JAN-01-1995 DEC-31-1996 DEC-31-1995 169 67 908 984 237 213 12 14 97 89 1,503 1,454 1,301 1,033 391 290 2,766 2,433 643 584 59 177 0 0 0 0 0 0 1,906 1,672 2,766 2,433 2,088 1,819 2,240 1,940 283 273 283 273 1,052 923 0 0 6 15 962 794 283 257 0 0 0 0 0 0 0 0 680 538 2.57 2.03 2.42 1.92 Restated pursuant to Regulaton S-K, Item 601(c), to conform to SFAS No. 128. "EPS-PRIMARY" denotes basic EPS. Amended to conform with the requirements of Regulation S-K, Item 601(c), Appendix A.
 

5 1,000,000 9-MOS 6-MOS 3-MOS DEC-31-1997 DEC-31-1997 DEC-31-1997 JAN-01-1997 JAN-01-1997 JAN-01-1997 SEP-30-1997 JUN-30-1997 MAR-31-1997 240 331 265 862 894 780 250 242 219 14 13 12 111 106 100 1,526 1,646 1,437 1,579 1,490 1,400 467 445 418 3,002 3,043 2,773 634 588 539 129 134 59 0 0 0 0 0 0 0 0 0 2,239 2,270 2,018 3,002 3,043 2,773 1,656 1,103 536 1,794 1,196 576 223 149 72 223 149 72 1,005 552 269 0 0 0 1 1 0 617 529 250 152 148 70 0 0 0 0 0 0 0 0 0 0 0 0 465 381 180 1.75 1.44 .68 1.68 1.37 .65 Restated pursuant to Regulation S-K, Item 601(c), to conform to SFAS No. 128. "EPS-PRIMARY" denotes basic EPS. Amended to conform with the requirements of Regulation S-K, Item 601 (c), Appendix A.
 

5 1,000,000 9-MOS 6-MOS 3-MOS DEC-31-1996 DEC-31-1996 DEC-31-1996 JAN-01-1996 JAN-01-1996 JAN-01-1996 SEP-30-1996 JUN-30-1996 MAR-31-1996 227 214 62 767 798 873 218 214 227 11 15 14 91 92 90 1,406 1,410 1,354 1,193 1,118 1,069 361 336 311 2,549 2,496 2,367 565 577 515 59 99 99 0 0 0 0 0 0 0 0 0 1,768 1,821 1,753 2,549 2,496 2,367 1,529 996 477 1,646 1,079 508 208 135 67 208 135 67 766 506 251 0 0 0 5 4 2 715 466 207 213 144 63 0 0 0 0 0 0 0 0 0 0 0 0 502 322 144 1.89 1.21 .54 1.78 1.14 .51 Restated pursuant to Regulation S-K, Item 601(c), to conform to SFAS No. 128. "EPS-PRIMARY" denotes basic EPS. Amended to conform with the requirements of Regulation S-K, Item 601 (c), Appendix A.