Filed pursuant to Rule 424(b)(3) Registration No. 333-88834 Prospectus Supplement No. 25 dated February 20, 2004 (To Prospectus dated May 31, 2002) $3,950,000,000 Amgen Inc. Liquid Yield Option(TM) Notes due 2032 (Zero Coupon--Senior) and Shares of Common Stock Issuable Upon Conversion of the Liquid Yield Option(TM) Notes This document supplements the prospectus dated May 31, 2002, as amended and supplemented through the date hereof, relating to the resale by the holders of Liquid Yield Option(TM) Notes (Zero Coupon--Senior) (the "LYONs") due March 1, 2032 and the shares of our common stock into which the LYONs are convertible. This prospectus supplement is incorporated by reference into, and should be read in conjunction with, the prospectus dated May 31, 2002, including any amendments or supplements to it. This prospectus supplement is not complete without, and may not be delivered or utilized except in connection with, the prospectus, including any amendments or supplements to it. The table presented below sets forth information as of the date of this prospectus supplement about the principal amount at maturity of the LYONs and the underlying common stock beneficially owned by each selling security holder that may be offered using the prospectus. All of the information set forth in the table has been provided by the selling security holders on or prior to the date of this prospectus supplement and, to our knowledge, is true and correct as of the date of this prospectus supplement. However, the selling security holders may have sold, transferred or otherwise disposed of all or a portion of their notes since the date on which they provided the information regarding their notes. The table of selling security holders contained on pages 42-45 of the prospectus dated May 31, 2002 is hereby amended and replaced by the table set forth below. Principal Amount of Shares of LYONs Stock LYONs Common Owned Owned Beneficially Stock Common After After Owned and Beneficially Stock Completion Completion Material Name Offered/(1)/ Owned Offered/(2)/ of Offering/(3)/ of Offering/(3)/ Relationship/(4)/ - ------------------- -------------- -------------- --------------- ------------------ ------------------ ------------------- 1976 Distribution Trust FBO A.R.Lauder / Zinterhofer .......... 18,000 159.5 159.5 -0- - None 1

1976 Distribution Trust FBO Jane A. Lauder....... ............................ 35,000 310.1 310.1 -0- - None 2000 Revocable Trust FBO A.R. Lauder / Zinterhofer .............................. 18,000 159.5 159.5 -0- - None ABC Ltd. .................................. 175,000 1,550.5 1,550.5 -0- - None Absolute Return Fund Ltd. ................. 5,941,000 52,637.9 52,637.9 -0- - None Advent Convertible Master Cayman L.P. ..... 6,242,000 55,304.7 55,304.7 -0- - None Aid Association for Lutherans, as successor to Lutheran Brotherhood ........ 11,000,000 97,461.1 97,461.1 -0- - None Akela Capital Master Fund, LLC............. 2,000,000 17,720.2 17,720.2 -0- - None Alembic Inc. .............................. 140,000 1,240.4 1,240.4 -0- - None Allentown City Firefighters Pension Plan... 62,000 549.3 549.3 -0- - None Allentown City Officers & Employees Pension Fund.............................. 45,000 398.7 398.7 -0- - None Allentown City Police Pension Plan......... 74,000 655.7 655.7 -0- - None Allgemeine Pensionskasse der Swissair Group..................................... 1,200,000 10,632.1 10,632.1 -0- - None Allstate Insurance Company................. 21,900,000/(5)/ 478,336.2/(5)/ 194,036.2/(5)/ -0-/(5)/ 284,300/(5)/ None Allstate Life Insurance Company............ 21,900,000/(5)/ 478,336.2/(5)/ 194,036.2/(5)/ -0-/(5)/ 284,300/(5)/ None Alpha US Sub Fund 4, LLC................... 675,000 5,980.6 5,980.6 -0- - None Alpha U.S. Sub Fund VIII, LLC.............. 2,300,000 20,378.2 20,378.2 -0- - None American Motorist Insurance Company........ 1,396,000 12,368.7 12,368.7 -0- - None Amerisure Mutual Insurance Company......... 975,000 8,638.6 8,638.6 -0- - None Arapahoe County Colorado................... 135,000 1,196.1 1,196.1 -0- - None 2

Arbitex Master Fund L.P.................... 8,000,000 70,880.8 70,880.8 -0- - None Argent Classic Convertible Arbitrage Fund L.P.......... 4,500,000 39,870.5 39,870.5 -0- - None Argent Classic Convertible Arbitrage Fund (Bermuda) Ltd......................... 6,000,000 53,160.6 53,160.6 -0- - None Argent LowLev Convertible Arbitrage Fund Ltd ......... 13,500,000 119,611.4 119,611.4 -0- - None Aristeia International Limited .................... 26,950,000 238,779.7 238,779.7 -0- - None Aristeia Trading LLC......... 8,050,000 71,323.8 71,323.8 -0- - None Arlington County Employees Retirement System........... 1,470,000 13,024.4 13,024.4 -0- - None Asset Insurance Company Ltd................. 615,000 5,449.0 5,449.0 -0- - None Associated Electric & Gas Insurance Services Limited .................... 3,000,000 26,580.3 26,580.3 -0- - None Atlantic Trust Company....... 4,720,000 323,301.7 41,819.7 -0- 281,482 None Auspicis Ltd................. 430,000 3,809.9 3,809.9 -0- - None Banc of America Securities LLC......................... 21,281,000 188,551.8 188,551.8 -0- - None Bank Austria AG.............. 240,000 2,126.4 2,126.4 -0- - None Bank Austria Cayman Islands, Ltd......................... 4,500,000 39,870.5 39,870.5 -0- - None Bank Hapoalim, B.M........... 6,000,000 53,160.0 53,160.6 -0- - None Bank of America Pension Plan........................ 2,500,000 22,150.3 22,150.3 -0- - None The Bank of New York Cede & Co. ........................ 425,000 3,765.5 3,765.5 -0- - None Barclays Global Investors Ltd. ....................... 1,500,000 13,290.2 13,290.2 -0- - None Bay State Insurance Company Ltd. ............... 340,000 3,012.4 3,012.4 -0- - None Beamtenversicherung-skasse des Kantons Zurich.......... 10,900,000 96,575.1 96,575.1 -0- - None Bear Stearns International Limited..................... 21,835,000 193,460.3 193,460.3 -0- - None Bear, Stearns & Co. Inc...... 9,500,000 84,171.0 84,171.0 -0- - None BGI Global Investors c/o Forest Investment Mngt. L.L.C. ..................... 685,000 6,069.2 6,069.2 -0- - None Black Diamond Capital I, Ltd......................... 2,432,000 21,547.8 21,547.8 -0- - None Black Diamond Convertible Offshore LDC................ 15,296,000 135,524.1 135,524.1 -0- - None Black Diamond Offshore Ltd......................... 8,647,000 76,613.3 76,613.3 -0- - None 3

British Virgin Islands Social Security Board..... ............................... 196,000 1,736.6 1,736.6 -0- - None BT Equity Opportunity ..................... 3,200,000 28,352.3 28,352.3 -0- - None BTES-Convertible Arb ...................... 1,000,000 8,860.1 8,860.1 -0- - None Canyon Capital Arbitrage Masterfund, Ltd... 3,750,000 33,225.4 33,225.4 -0- - None Canyon Mac 18, Ltd. (RMF).................. 625,000 5,537.6 5,537.6 -0- - None Canyon Value Realization Fund (Cayman), Ltd....................................... 5,625,000 49,838.1 49,838.1 -0- - None Canyon Value Realization Fund, L.P......... 2,500,000 22,150.3 22,150.3 -0- - None Cater Allen International Limited ......... 90,000,000 1,059,509.0 797,409.0 -0- 262,100 None The Captive Fixed Income Fund ............. 1,110,000 9,834.7 9,834.7 -0- - None The Captive Investors Fund ................ 1,005,000 8,904.4 8,904.4 -0- - None CCI Investments Company, Ltd. ............. 55,000 487.3 487.3 -0- - None CDC Financial Products, Inc. .............. 20,000,000 177,202.0 177,202.0 -0- - None CDC Ixis Paris............................. 20,000,000 177,202.0 177,202.0 -0- - None Chicago Standard Insurance Company, Ltd. .. 85,000 753.1 753.1 -0- - None Circlet (IMA) Ltd.......................... 1,500,000 13,290.2 13,290.2 -0- - None CitiSAM Ltd. .............................. 24,700,000 218,844.3 218,844.3 -0- - None City of New Orleans........................ 558,000 4,943.9 4,943.9 -0- - None City University of New York................ 335,000 2,968.1 2,968.1 -0- - None Clinton Convertible Managed Trading Account 1 Limited......................... 4,250,000 37,655.4 37,655.4 -0- - None Clinton Multistrategy Master Fund, Ltd. ... 18,225,000 161,475.3 161,475.3 -0- - None Clinton Riverside Convertible Portfolio Limited................................... 20,025,000 177,423.5 177,423.5 -0- - None Cobra Master Fund, Ltd..................... 1,500,000 13,290.2 13,290.2 -0- - None Commerce Bank NA as Custodian for Greater STL Const Lab Pen......................... 700,000 56,202.1 6,202.1 -0- 50,000 None Commerce Bank NA as Custodian for Plum & Pipefitters Loc 562 Pen................... 300,000 20,658.0 2,658.0 -0- 18,000 None Commonwealth Professional Assurance Co. c/o Income Research & Management .................... 600,000 5,316.1 5,316.1 -0- - None Conseco Annuity Assurance Multi Bucket Annuity Convertible Bond Fund .................... 9,750,000 86,386.0 86,386.0 -0- - None Conseco Fund Group Convertible Securities Fund ............... 250,000 2,215.0 2,215.0 -0- - None Continental Assurance Company on behalf of its Separate Account E ................... 7,200,000 63,792.7 63,792.7 -0- - None Continental Casualty Company............... 44,800,000 396,932.5 396,932.5 -0- - None Credit Industriel D'Alsace Et De Lorraine.. 25,400,000 225,046.5 225,046.5 -0- - None Credit Lyonnais SEC USA.................... 28,000,000 248,082.8 248,082.8 -0- - None Credit Suisse First Boston Corporation ....................... 2,400,000 21,264.2 21,264.2 -0- - None Credit Suisse First Boston Europe Ltd...... 278,650,000 2,468,866.9 2,468,866.9 -0- - None Credit Suisse First Boston International ............................ 86,000,000 761,968.6 761,968.6 -0- - None 4

DaimlerChrysler Corp Emp. #1 Pension Plan dtd 4/1/89 ................ 13,980,000 123,864.2 123,864.2 -0- - None Dcash Convertible............ 3,300,000 29,238.3 29,238.3 -0- - None Deephaven Domestic Convertible Trading Ltd........................ 165,850,000 1,469,447.6 1,469,447.6 -0- - None Deeprock & Co................ 3,000,000 26,580.3 26,580.3 -0- - None Deutsche Bank AG London..................... 45,000,000 398,704.5 398,704.5 -0- - None Deutsche Bank Securities Inc........................ 471,600,000 4,178,423.2 4,178,423.2 -0- - None DKR Fixed Income Holding Fund Ltd................... 3,000,000 26,580.3 26,580.3 -0- - None D.L.& C. Insurance Company, Limited ................... 105,000 930.3 930.3 -0- - None Double Black Diamond Offshore LDC............... 50,469,000 447,160.4 447,160.4 -0- - None Dylan (IMA) Ltd.............. 5,000,000 44,300.5 44,300.5 -0- - None Erste Bank der oesterreichischen Sparkassen AG.............. 340,000 3,012.4 3,012.4 -0- - None Excellus Health Plans c/o Income Research & Management................. 2,600,000 23,036.3 23,036.3 -0- - None Family Service Life Insurance Co............... 300,000 2,658.0 2,658.0 -0- - None First Union Securities Inc........................ 20,000,000 177,202.0 177,202.0 -0- - None Forest Alternative Strategies II.............. 186,000 1,648.0 1,648.0 -0- - None Forest Fulcrum Fund L.L.P...................... 2,592,000 22,965.4 22,965.4 -0- - None Forest Global Convertible Fund Series A-5................. 9,682,000 85,783.5 85,783.5 -0- - None Franklin and Marshall College.................... 785,000 6,955.2 6,955.2 -0- - None Gaia Offshore Master Fund Ltd................... 6,450,000 57,147.6 57,147.6 -0- - None GDO Equity Arbitrage Master Fund................ 7,500,000 66,450.8 66,450.8 -0- - None Gemini Sammel Stiftung Zur Forderung der Personalvorsorge .......... 450,000 3,987.0 3,987.0 -0- - None Georgia Municipal Employee Benefit System..................... 1,500,000 13,290.2 13,290.2 -0- - None Global Bermuda Limited Partnership................ 7,000,000 62,020.7 62,020.7 -0- - None GM Employees Global Group Pension Trust........ 2,000,000 17,720.2 17,720.2 -0- - None Goldman Sachs & Co. Profit Sharing Master Trust...................... 5,371,000 47,587.6 47,587.6 -0- - None Goldman Sachs and Company.................... 46,920,000 415,715.9 415,715.9 -0- - None 5

Government of Singapore Investment Corporation Pte Ltd...................... 10,000,000 1,859,593.0 88,601.0 -0- 1,770,992 None The Grable Foundation........ 261,000 2,312.5 2,312.5 -0- - None Grady Hospital Foundation.... 294,000 2,604.9 2,604.9 -0- - None Granville Capital Corporation................. 35,000,000 310,103.5 310,103.5 -0- - None Great-West Life & Annuity Insurance Company.... 14,000,000 124,041.4 124,041.4 -0- - None Guardian Life Insurance Co........................... 16,000,000 141,761.6 141,761.6 -0- - None Guardian Pension Trust....... 1,700,000 15,062.2 15,062.2 -0- - None Gulf International Bank UK Ltd....................... 4,000,000 35,440.4 35,440.4 -0- - None Hamilton Multi-Strategy Master Fund, LP............. 6,000,000 53,160.6 53,160.6 -0- - None Hartford Life Insurance Co................ 44,721,000 602,115.5 396,232.5 -0- 205,883 None HBK Master Fund, L.P......... 17,000,000 172,821.7 150,621.7 -0- 22,200 None HFR CA Select Fund........... 700,000 6,202.0 6,202.0 -0- - None HFR Convertible Arbitrage Account..................... 581,000 5,147.7 5,147.7 -0- - None Highbridge International LLC......................... 148,150,000 1,312,623.8 1,312,623.8 -0- - None HSBC Trustee, Zola Managed Trust....................... 400,000 3,544.0 3,544.0 -0- - None IMF Convertible Fund ........ 3,800,000 33,668.4 33,668.4 -0- - None Independence Blue Cross...... 901,000 7,983.0 7,983.0 -0- - None ING Convertible Fund......... 3,960,000 35,086.0 35,086.0 -0- - None ING VP Convertible Fund...... 40,000 354.4 354.4 -0- - None Investcorp SAM Fund Ltd. .... 20,400,000 180,746.0 180,746.0 -0- - None Jefferies & Co. Inc......... 2,500,000 22,150.3 22,150.3 -0- - None Jersey (IMA) Ltd............. 3,000,000 26,580.3 26,580.3 -0- - None JP Morgan Securities Inc..... 304,000,000 2,716,454.5 2,693,470.5 -0- 22,974 None Kallista Master Fund Limited ................ 11,500,000 101,891.2 101,891.2 -0- - None KBC Financial Products (Cayman Island) Limited..... 85,000,000 753,108.5 753,108.5 -0- - None KBC Financial Products USA Inc......................... 5,280,000 46,781.3 46,781.3 -0- - None Kenwood Insurance Company, Ltd......................... 520,000 4,607.3 4,607.3 -0- - None Key-Royal Reinsurance Company Limited ........... 60,000 531.6 531.6 -0- - None Lakeshore International, Ltd......................... 28,000,000 248,082.8 248,082.8 -0- - None Lehman Brothers Inc.......... 10,000,000 88,601.0 88,601.0 -0- - None Lehman Brothers Special Financing Inc............... 144,000,000 1,275,854.4 1,275,854.4 -0- - None 6

Lexington (IMA) Limited...... 10,051,000 89,052.9 89,052.9 -0- - None Liberty View Fund LLC........ 2,000,000 17,720.2 17,720.2 -0- - None Liberty View Funds L.P....... 9,000,000 79,740.9 79,740.9 -0- - None Liberty View Global Volatility Fund............. 26,000,000 230,362.6 230,362.6 -0- - None LLT Limited.................. 685,000 6,069.2 6,069.2 -0- - None Lydian Overseas Partners Master Fund......... 59,000,000 522,745.9 522,745.9 -0- - None Lyxor........................ 1,185,000 10,499.2 10,499.2 -0- - None Lyxor Master Fund............ 1,550,000 13,733.2 13,733.2 -0- - None Lyxor Master Fund c/o Forest Investment Mngt. L.L.C................ 2,700,000 23,922.3 23,922.3 -0- - None Lyxor Master Fund, c/o Zola Capital Management, LLC............ 4,750,000 42,085.5 42,085.5 -0- - None Lyxor Master Fund Ref: Argent/LowLev CB........... 3,000,000 26,580.3 26,580.3 -0- - None Marathon Global Convertible Master Fund, Ltd.................. 11,500,000 101,891.2 101,891.2 -0- - None McMahan Securities Co. L.P........................ 4,000,000 35,440.4 35,440.4 -0- - None Med America Insurance Co. ... 3,170,000 28,086.5 28,086.5 -0- - None Med America Hartford Trust Co. c/o Income Research & Management........ 505,000 4,474.4 4,474.4 -0- - None Med America New York Insurance Co. c/o Income Research & Management........ 1,325,000 11,739.6 11,739.6 -0- - None Medical Liability Mutual Insurance Co. ............... 8,000,000 70,880.8 70,880.8 -0- - None Merrill Lynch Insurance Group...................... 725,000 6,423.6 6,423.6 -0- - None Merrill Lynch International Limited...... 6,000,000 232,719.6 53,160.6 -0- 179,559 None Merrill Lynch, Pierce, Fenner & Smith, Inc........ 117,740,000 1,043,188.2 1,043,188.2 -0- - None Minnesota Power and Light...................... 171,000 1,515.1 1,515.1 -0- - None MLQA Convertible Securities Arbitrage, Ltd. ...................... 25,000,000 221,502.5 221,502.5 -0- - None Morgan Stanley & Co. ........ 50,500,000 447,435.1 447,435.1 -0- - None Municipal Employees.......... 503,000 4,456.6 4,456.6 -0- - None New Orleans Firefighters Pension / Relief Fund...... 302,000 2,675.8 2,675.8 -0- - None NGSC Insurance Limited ...... 65,000 575.9 575.9 -0- - None Nicholas Applegate Investment Grade Convertible................ 37,000 327.8 327.8 -0- - None NMS Services (Cayman) Inc........................ 50,000,000 443,005.0 443,005.0 -0- - Nomura International Plc..... 6,000,000 53,160.6 53,160.6 -0- - None 7

Occidental Petroleum Corporation................. 569,000 5,041.4 5,041.4 -0- - None Ohio Bureau of Workers Compensation................ 389,000 3,446.6 3,446.6 -0- - None 0Z Convertible Master Fund, Ltd................... 22,712,000 201,230.6 201,230.6 -0- - None 0Z Mac 13 Ltd................. 5,521,000 48,916.6 48,916.6 -0- - None 0Z Master Fund, Ltd........... 247,824,000 2,195,745.4 2,195,745.4 -0- - None Pacific Life Insurance Company .................... 110,000,000 974,611.0 974,611.0 -0- - None Palo Verde Insurance Company, Ltd................ 170,000 1,506.2 1,506.2 -0- - None Pensionskasse Ciba Specialty Chemicals......... 1,900,000 16,834.2 16,834.2 -0- - None Pensionskasse der Antalis AG.................. 220,000 1,949.2 1,949.2 -0- - None Pensionskasse der EMS-Chemie AG............... 270,000 2,392.2 2,392.2 -0- - None Pensionskasse der EMS-Chemie AG Domat......... 270,000 2,392.2 2,392.2 -0- - None Pensionskasse der EMS-Dottikon AG ............ 400,000 3,544.0 3,544.0 -0- - None Pensionskasse der Lonza AG ................... 500,000 4,430.1 4,430.1 -0- - None Pensionskasse der Rockwell Automation AG .............. 270,000 2,392.2 2,392.2 -0- - None Pensionskasse Pluss- Staufer AG ................. 250,000 2,215.0 2,215.0 -0- - None Pensionskasse Vantico ........ 380,000 3,366.8 3,366.8 -0- - None Peoples Benefit Life Insurance Company Teamsters .................. 7,500,000 66,450.8 66,450.8 -0- - None Performa Institutional Fund US Dollar Convertible Bond ........... 150,000 1,329.0 1,329.0 -0- - None Plexus Fund Limited .......... 4,000,000 35,440.4 35,440.4 -0- - None Policeman and Firemen Retirement System of the City of Detroit .................... 1,380,000 12,226.9 12,226.9 -0- - None Privilege Portfolio Global Convertibles ........ 3,000,000 26,580.3 26,580.3 -0- - None Professional Liability Ins. Co. of America......... 25,000 221.5 221.5 -0- - None Pro-mutual ................... 1,654,000 14,654.6 14,654.6 -0- - None 8

Quattro Fund ................. 8,910,000 78,943.5 78,943.5 -0- - None Ram Trading .................. 7,000,000 62,020.7 62,020.7 -0- - None Ramius Capital Group ......... 500,000 4,430.1 4,430.1 -0- - None Ramius LP .................... 1,000,000 8,860.1 8,860.1 -0- - None RBC Capital Services c/o Forest Investment Mngt. L.L.C. ..................... 382,000 3,384.6 3,384.6 -0- - None RCG Baldwin LP ............... 1,500,000 13,290.2 13,290.2 -0- - None RCG Halifax Master Fund, Ltd. ................. 1,500,000 13,290.2 13,290.2 -0- - None RCG Latitude Master Fund, Ltd. ................. 2,500,000 22,150.3 22,150.3 -0- - None RCG Multi Strategy, LP ....... 3,000,000 26,580.3 26,580.3 -0- - None Relay 11. Holdings c/o Forest Investment Mngt. L.L.C. ............. 345,000 3,056.7 3,056.7 -0- - None Retail Clerks Pension Trust 2 .................. 2,000,000 17,720.2 17,720.2 -0- - None Rhapsody Fund, L.P. ........ 39,100,000 346,429.9 346,429.9 -0- - None Royal Bank of Canada Trust Company (Jersey) Limited .......... 5,000,000 44,300.5 44,300.5 -0- - None S.A.C. Capital Associates, LLC .......... 47,500,000 420,854.8 420,854.8 -0- 100,000 None Sagamore Hill Rub Fund Ltd. ................ 30,500,000 270,233.1 270,233.1 -0- - None Salomon Brothers Asset Management, Inc. ......... 55,000,000 487,305.5 487,305.5 -0- - None Salomon Smith Barney Inc. ..................... 31,836,000 282,070.1 282,070.1 -0- - None San Diego County Employees Retirement Association .............. 2,000,000 17,720.2 17,720.2 -0- - None Serena Limited ............. 2,080,000 18,429.0 18,429.0 -0- - None Shell Pension Trust ........ 871,000 7,717.2 7,717.2 -0- - None Sicav Placeuro.............. 425,000 4,715.5 3,765.5 -0- 950 None St. Albans Partners Ltd .... 5,000,000 44,300.5 44,300.5 -0- - None State of Maryland Retirement Agency ........ 7,078,000 62,711.8 62,711.8 -0- - None State of Mississippi Health Care Trust Fund ... 825,000 7,309.6 7,309.6 -0- - None State Street Bank Custodian for GE Pension Trust ............ 6,405,000 56,748.9 56,748.9 -0- - None 9

Susquehanna Capital Group ..................... 5,000,000 44,300.5 44,300.5 -0- - None SuttonBrook Capital Portfolio, LP ............. 14,500,000 128,471.5 128,471.5 -0- - None SwissFirst Trust AG ......... 3,000,000 26,580.3 26,580.3 -0- - None Sylvan (IMA) Ltd. c/o Forest Investment Mngt. L.L.C. .............. 1,520,000 13,467.4 13,467.4 -0- - None Tag Associates .............. 151,000 1,337.9 1,337.9 -0- - None TD Securities (USA) Inc. .... 65,000,000 575,906.5 575,906.5 -0- - None Teachers Insurance & Annuity Association ....... 16,000,000 141,761.6 141,761.6 -0- - None Thomas Weisel Partners .................. 1,029,000 9,177.0 9,177.0 -0- - None Thrivent Financial for Lutherans (f/k/a Aid Association for Lutherans) ................ 4,000,000 35,440.4 35,440.4 -0- - None TQA Master Fund, Ltd. ....... 7,000,000 62,020.7 62,020.7 -0- - None TQA Master Plus Fund, Ltd. ...................... 4,500,000 39,870.5 39,870.5 -0- - None Tribecca Investments, LLC ....................... 60,000,000 531,606.0 531,606.0 -0- - None Trustmark Insurance ......... 760,000 6,733.7 6,733.7 -0- - None Tufts Associated Health Plan c/o Income Research & Management ....... 2,000,000 17,720.2 17,720.2 -0- - None UBS AG London Branch ........ 144,000,000 1,275,854.4 1,275,854.4 -0- - None UBS O'Connor LLC F/B/O O'Connor Global Convertible Portfolio ................. 750,000 6,645.1 6,645.1 -0- - None UBS O'Connor LLC F/B/O UBS Global Equity Arbitrage Master Ltd. ............... 35,000,000 310,103.5 310,103.5 -0- - None UBS Warburg LLC ............. 28,560,000 253,044.5 253,044.5 -0- - None UFJ Investments Asia Ltd .... 25,000,000 221,502.5 221,502.5 -0- - None UMASS Memorial Investment Partnership c/o Income Research & Management ................ 250,000 2,215.0 2,215.0 -0- - None UMASS Memorial Health Care c/o Income Research & Management ................ 250,000 2,215.0 2,215.0 -0- - None US Bancorp Piper Jaffray .... 5,707,000 50,564.6 50,564.6 -0- - None 10

Victory Capital Management as Agent for the Key Trust Convertible Securities Fund ........... 290,000 2,569.4 2,569.4 -0- None Victory Capital Management as Agent for the EB Convertible Securities Fund ........... 1,610,000 14,264.8 14,264.8 -0- None Victory Capital Management as Agent for the Charitable Convertible Securities Fund .......... 1,675,000 14,840.7 14,840.7 -0- None Victory Capital Management as Agent for the Field Foundation of Illinois ................. 90,000 797.4 797.4 -0- None Victory Capital Management as Agent for the GenCorp Foundation ............... 70,000 620.2 620.2 -0- None Victory Capital Management as Agent for the Parker Key/Convertible .......... 820,000 7,265.3 7,265.3 -0- None Victory Capital Management as Investment Manager for Potlatch ............. 1,175,000 10,410.6 10,410.6 -0- None Victory Capital Management as Trustee for the Key Trust Fixed Income Fund ..................... 480,000 4,252.8 4,252.8 -0- None Victory Capital Management as Trustee for the Charitable Income Fund ..................... 315,000 2,790.9 2,790.9 -0- None Victory Capital Management as Agent for California State Automobile Association Inter Insurance ................ 600,000 5,316.1 5,316.1 -0- None Victory Capital Management as Agent for California State Automobile Association Retirement Pension ....... 125,000 1,107.5 1,107.5 -0- None 11

Victory Capital Management as Agent for American Booksellers .............. 40,000 354.4 354.4 -0- None Victory Capital Management as Agent for Health Foundation of Greater Cincinnati ....... 250,000 2,215.0 2,215.0 -0- None Victory Capital Management as Investment Manager for Compsource Oklahoma ................. 300,000 2,658.0 2,658.0 -0- None Victory Capital Management as Investment Manager for Georgia Municipal Retirement Trust .................... 750,000 6,645.1 6,645.1 -0- None Victory Capital Management as Investment Manager for Stamford Police Pension Fund .............. 50,000 443.0 443.0 -0- None Von Ernst Global Portfolio - Convertible Bond Fund ..... 1,300,000 11,518.1 11,518.1 -0- - None Wachovia Bank National Association ............... 20,000,000 177,202.0 177,202.0 -0- - None Wachovia Securities International Ltd. ........ 31,000,000 274,663.1 274,663.1 -0- - None White River Securities LLC ....................... 9,500,000 84,171.0 84,171.0 -0- - None Worldwide Transactions Ltd. ...................... 2,156,000 19,102.4 19,102.4 -0- - None Yield Strategies Fund I, L.P. ................... 5,000,000 44,300.5 44,300.5 -0- - None Yield Strategies Fund II, L.P. .................. 5,000,000 44,300.5 44,300.5 -0- - None Zazove Convertible Arbitrage Fund L.P. ....... 500,000 4,430.1 4,430.1 -0- - None Zazove Hedged Convertible Fund L.P. ..... 2,800,000 24,808.3 24,808.3 -0- - None Zazove Income Fund L.P. ..... 2,000,000 17,720.2 17,720.2 -0- - None Zola Partners, L.P. ......... 7,250,000 64,235.7 64,235.7 -0- - None Zurich Institutional Benchmark Management c/o Quattro Fund .......... 3,590,000 31,807.8 31,807.8 -0- - None Zurich Institutional Benchmarks Master Fund Ltd. ................. 2,800,000 24,808.3 24,808.3 -0- - None Zurich Master Hedge Fund c/o Forest Investments Mngt. L.L.C. .................... 1,223,000 10,835.9 10,835.9 -0- - None - --------------------------------- (1) Total principal amount of selling securityholders listed is more than $3,950,000,000 because certain of the selling securityholders may have transferred LYONs pursuant to Rule 144A or otherwise reduced their position prior to selling pursuant to this Registration Statement. The maximunm principal amount of LYONs that may be sold under this prospectus will not exceed $3,950,000,000. (2) Represents shares of common stock issuable upon conversion of LYONs that are beneficially owned and offered by the selling security holder. (3) Assumes that all of the LYONs and/or all of the common stock into which the LYONs are convertible are sold. (4) Includes any position, office or other material relationship which the selling security holder has had within the past three years with Amgen or any of its predecessors or affiliates. (5) Allstate Insurance Company and Allstate Life Insurance Company are affiliated entities. Allstate Insurance Company is the record owner of $4,000,000 principal amount of LYONs and Allstate Life Insurance Company is the record owner of $17,900,000 principal amount of LYONs. Aside from the LYONs and the common stock into which the LYONs are convertible, Allstate Insurance Company is the record owner of 180,300 shares of our common stock and Allstate Insurance Company and its affiliates beneficially own an aggregate of 284,300 shares of our common stock. See "Risk Factors" section beginning on page 8 of the prospectus to read about factors you should consider before purchasing the LYONs or our common stock. Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense. The date of this prospectus supplement is February 20, 2004 (TM) Trademark of Merrill Lynch & Co., Inc.