SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* PERLMUTTER ROGER M (Last) (First) (Middle) ONE AMGEN CENTER DRIVE (Street) THOUSAND OAKS CA 91320-1799 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol AMGEN INC [ AMGN ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director 10% Owner X Officer (give title below) Other (specify below) Exe VP, Research & Development
	3. Date of Earliest Transaction (Month/Day/Year) 11/17/2005
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/17/2005		M		100,000	A	$58.6875	148,281	D
Common Stock	11/17/2005		S		5,000	D	$82.19	143,281	D
Common Stock	11/17/2005		S		7,000	D	$82.21	136,281	D
Common Stock	11/17/2005		S		1,000	D	$82.2596	135,281	D
Common Stock	11/17/2005		S		2,000	D	$82.27	133,281	D
Common Stock	11/17/2005		S		1,000	D	$82.283	132,281	D
Common Stock	11/17/2005		S		2,000	D	$82.3	130,281	D
Common Stock	11/17/2005		S		1,000	D	$82.3061	129,281	D
Common Stock	11/17/2005		S		1,000	D	$82.3168	128,281	D
Common Stock	11/17/2005		S		1,000	D	$82.32	127,281	D
Common Stock	11/17/2005		S		1,000	D	$82.3238	126,281	D
Common Stock	11/17/2005		S		2,000	D	$82.34	124,281	D
Common Stock	11/17/2005		S		1,000	D	$82.3445	123,281	D
Common Stock	11/17/2005		S		1,000	D	$82.35	122,281	D
Common Stock	11/17/2005		S		4,000	D	$82.37	118,281	D
Common Stock	11/17/2005		S		1,000	D	$82.3741	117,281	D
Common Stock	11/17/2005		S		10,000	D	$82.38	107,281	D
Common Stock	11/17/2005		S		1,000	D	$82.3834	106,281	D
Common Stock	11/17/2005		S		1,000	D	$82.3869	105,281	D
Common Stock	11/17/2005		S		1,000	D	$82.3872	104,281	D
Common Stock	11/17/2005		S		1,000	D	$82.3874	103,281	D
Common Stock	11/17/2005		S		1,000	D	$82.3904	102,281	D
Common Stock	11/17/2005		S		1,000	D	$82.4106	101,281	D
Common Stock	11/17/2005		S		1,000	D	$82.4139	100,281	D
Common Stock	11/17/2005		S		1,000	D	$82.418	99,281	D
Common Stock	11/17/2005		S		1,000	D	$82.4254	98,281	D
Common Stock	11/17/2005		S		1,000	D	$82.4285	97,281	D
Common Stock	11/17/2005		S		10,000	D	$82.43	87,281	D
Common Stock	11/17/2005		S		4,000	D	$82.44	83,281	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
NQSO (Right to Buy)	$58.6875	11/17/2005		M			100,000	01/08/2002	01/08/2008	Common Stock	100,000	$58.6875	93,188	D

Explanation of Responses:

	/s/ Roger M Perlmutter	11/18/2005
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.