SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* PERLMUTTER ROGER M (Last) (First) (Middle) ONE AMGEN CENTER DRIVE (Street) THOUSAND OAKS CA 91320-1799 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol AMGEN INC [ AMGN ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director 10% Owner X Officer (give title below) Other (specify below) Exe VP, Research & Development
	3. Date of Earliest Transaction (Month/Day/Year) 11/17/2005
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/17/2005		S		1,000	D	$82.1901	82,281	D
Common Stock	11/17/2005		S		1,000	D	$82.1919	81,281	D
Common Stock	11/17/2005		S		1,000	D	$82.1979	80,281	D
Common Stock	11/17/2005		S		1,000	D	$82.199	79,281	D
Common Stock	11/17/2005		S		1,000	D	$82.2299	78,281	D
Common Stock	11/17/2005		S		7,000	D	$82.24	71,281	D
Common Stock	11/17/2005		S		1,000	D	$82.2421	70,281	D
Common Stock	11/17/2005		S		3,000	D	$82.25	67,281	D
Common Stock	11/17/2005		S		2,000	D	$82.2561	65,281	D
Common Stock	11/17/2005		S		1,000	D	$82.2641	64,281	D
Common Stock	11/17/2005		S		1,000	D	$82.2731	63,281	D
Common Stock	11/17/2005		S		1,000	D	$82.2998	62,281	D
Common Stock	11/17/2005		S		1,000	D	$82.3311	61,281	D
Common Stock	11/17/2005		S		1,000	D	$82.3605	60,281	D
Common Stock	11/17/2005		S		3,000	D	$82.39	57,281	D
Common Stock	11/17/2005		S		1,000	D	$82.394	56,281	D
Common Stock	11/17/2005		S		1,000	D	$82.3962	55,281	D
Common Stock	11/17/2005		S		1,000	D	$82.4013	54,281	D
Common Stock	11/17/2005		S		2,000	D	$82.41	52,281	D
Common Stock	11/17/2005		S		3,000	D	$82.42	49,281	D
Common Stock	11/17/2005		S		1,000	D	$82.4205	48,281	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

	/s/ Roger M Perlmutter	11/18/2005
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.