Document

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington D.C. 20549
FORM 11-K
(Mark One)
 ýANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the fiscal year ended December 31, 2022
OR
 
 ¨TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
Commission file number 001-37702
THE RETIREMENT AND SAVINGS PLAN FOR
AMGEN MANUFACTURING, LIMITED
State Road 31, Kilometer 24.6, Juncos, Puerto Rico 00777
(Full title and address of the plan)
AMGEN INC.
(Name of issuer of the securities held)
 
One Amgen Center Drive, 91320-1799
Thousand Oaks, California (Zip Code)
(Address of principal executive offices) 





The Retirement and Savings Plan for
Amgen Manufacturing, Limited

Audited Financial Statements
and Supplemental Schedule
Year Ended December 31, 2022

Contents
 
Audited Financial Statements:
Supplemental Schedule:




Report of Independent Registered Public Accounting Firm

To the Plan Participants and the Plan Administrator of The Retirement and Savings Plan for Amgen Manufacturing, Limited
Opinion on the Financial Statements
We have audited the accompanying statements of net assets available for benefits of The Retirement and Savings Plan for Amgen Manufacturing, Limited (the Plan) as of December 31, 2022 and 2021, and the related statement of changes in net assets available for benefits for the year ended December 31, 2022, and the related notes (collectively referred to as the “financial statements”). In our opinion, the financial statements present fairly, in all material respects, the net assets available for benefits of the Plan at December 31, 2022 and 2021, and the changes in its net assets available for benefits for the year ended December 31, 2022, in conformity with U.S. generally accepted accounting principles.
Basis for Opinion
These financial statements are the responsibility of the Plan’s management. Our responsibility is to express an opinion on the Plan’s financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Plan in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.
We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Plan is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Plan’s internal control over financial reporting. Accordingly, we express no such opinion.
Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.
Supplemental Schedule Required by ERISA
The accompanying supplemental schedule of assets (held at end of year) as of December 31, 2022, (referred to as the “supplemental schedule”), has been subjected to audit procedures performed in conjunction with the audit of the Plan’s financial statements. The information in the supplemental schedule is the responsibility of the Plan’s management. Our audit procedures included determining whether the information reconciles to the financial statements or the underlying accounting and other records, as applicable, and performing procedures to test the completeness and accuracy of the information presented in the supplemental schedule. In forming our opinion on the information, we evaluated whether such information, including its form and content, is presented in conformity with the Department of Labor’s Rules and Regulations for Reporting and Disclosure under the Employee Retirement Income Security Act of 1974. In our opinion, the information is fairly stated, in all material respects, in relation to the financial statements as a whole.
/s/ ERNST & YOUNG LLP
We have served as the Plan’s auditor since 1992.
Los Angeles, California
June 14, 2023
1



The Retirement and Savings Plan for Amgen Manufacturing, Limited
Statements of Net Assets Available for Benefits

 December 31,
 20222021
Assets
Investments at fair value$595,003,942 $669,938,625 
Notes receivable from participants16,068,774 15,668,200 
Other – principally due from broker395,402 469,779 
Total assets611,468,118 686,076,604 
Liabilities
Other – principally due to broker462,064 404,824 
Total liabilities462,064 404,824 
Net assets available for benefits$611,006,054 $685,671,780 
See accompanying notes.
2



The Retirement and Savings Plan for Amgen Manufacturing, Limited
Statement of Changes in Net Assets Available for Benefits

 Year Ended December 31,
 2022
Additions to (deductions from) net assets:
Employer contributions$20,160,074 
Participant contributions19,306,766 
Rollover contributions521,004 
Interest and dividend income5,053,185 
Net realized/unrealized losses(83,780,824)
Interest income on notes receivable from participants682,956 
Benefits paid(35,673,066)
Investment and administrative fees(935,821)
Net decrease(74,665,726)
Net assets available for benefits at beginning of year685,671,780 
Net assets available for benefits at end of year$611,006,054 
See accompanying notes.
3



The Retirement and Savings Plan for Amgen Manufacturing, Limited
Notes to Financial Statements
December 31, 2022

1. Description of the Plan
The following description of The Retirement and Savings Plan for Amgen Manufacturing, Limited (the Plan) provides only general information. Participants should refer to the Plan document for a more complete description of the Plan’s provisions.
General
The Plan was established effective May 1, 1992, and was amended and restated effective January 1, 2017, and subsequently amended, with the most recent amendment adopted on December 13, 2021. The Plan is a defined contribution plan covering substantially all Puerto Rico resident employees of Amgen Manufacturing, Limited (the Company), a wholly owned subsidiary of Amgen Inc. (Amgen). The Plan is intended to qualify under Section 1081.01 of the Puerto Rico Internal Revenue Code of 2011, as amended (the PR Code) (see Note 4, Income Tax Status) and section 407(d)(3)(A) of the Employee Retirement Income Security Act of 1974 (ERISA).
Contributions
Subject to certain limitations (as defined in the Plan), participants may elect to contribute up to 30% of their eligible compensation in pre-tax contributions and after-tax contributions or a combination of these types of contributions (together, Individual Contributions). A participant’s pre-tax contributions are subject to the PR Code and Plan limitations and could not exceed $15,000 in 2022. Participants may elect to contribute after-tax contributions beginning January 1 of the year following the year the participant was hired. Participant after-tax contributions are subject to the PR Code and Plan limitations and could not exceed $1,500 in 2022. Unless an employee has voluntarily enrolled in the Plan or has declined to participate in the Plan within the first 30 days of employment, all newly eligible participants are automatically enrolled in the Plan, and contributions equal to 5% of their eligible compensation are withheld and contributed to the Plan as pre-tax contributions; such contributions are automatically increased by 1% per year until their contributions reach 10% of their eligible compensation. Participants may elect to adjust, cease or resume their Individual Contributions at any time.
Participants who are at least age 50 by the close of the Plan year may also elect to make certain additional pre-tax Individual Contributions, referred to as catch-up contributions, that are subject to the PR Code and Plan limitations and could not exceed $1,500 in 2022. Participants may also contribute pre-tax and after-tax amounts representing distributions from certain other retirement plans qualified in Puerto Rico, referred to as rollover contributions (as defined in the Plan).
Each pay period, the Company makes a non-elective contribution for all eligible participants, whether or not they have elected to make Individual Contributions to the Plan, equal to 4% of each participant’s eligible compensation up to a maximum of $12,200 in 2022 (Core Contributions). In addition, the Company makes a contribution equal to amounts contributed by the participant as pre-tax contributions, including catch-up contributions, of up to 5% of eligible compensation (Matching Contributions). Matching Contributions could not exceed $15,000 in 2022.
Participants select the investments in which their Individual Contributions, including their Core Contributions and Matching Contributions (collectively, Company Contributions), are to be invested, electing among various alternatives, including Amgen common stock (Amgen stock). Participants may direct a maximum of 20% of contributions to be invested in Amgen stock. In addition, participants may transfer amounts among the investment options at any time, subject to certain limitations. Notwithstanding the foregoing, if 20% or more of the value of a participant’s Plan account is invested in Amgen stock, the Plan document provides that no transfers from other investment options can be made to invest in Amgen stock.
The accounts of participants who had never made an investment election are allocated to investments under a qualified default investment alternative, which is intended to be compliant with ERISA regulations. At any time, participants may elect to alter the investments in their accounts made under a qualified default investment alternative.
4



The Retirement and Savings Plan for Amgen Manufacturing, Limited
Notes to Financial Statements (continued)

Vesting
Participants are immediately vested with respect to their Individual Contributions and Matching Contributions and earnings and losses (hereafter referred to as earnings) thereon. Participants hired prior to January 1, 2020, are also immediately vested with respect to their Core Contributions and earnings thereon. Participants hired on or after January 1, 2020, vest in full with respect to their Core Contributions and earnings thereon after three years of service, as defined by the terms of the Plan, or upon reaching age 65 while employed by the Company, if earlier. If a participant ceases to be an employee before fully vesting in their account, the non-vested portion of the participant’s account will be treated as a forfeiture, as defined by the terms of the Plan, on the earlier of (a) the date the participant incurs a five-year break in service, as defined by the terms of the Plan or, (b) the date the participant receives a distribution of the entire vested portion of their account.
Participant Accounts
Each participant’s account is credited with: (a) the participant’s Individual Contributions; (b) an allocation of Company Contributions; and (c) earnings. The benefit to which a participant is entitled is the benefit that can be provided from the participant’s account.
Plan Investments
Plan participants can invest in seven different asset classes as well as Amgen stock or can actively manage their account under a self-directed brokerage arrangement in which a wider array of investment options are available. The value of an investment in an asset class is determined by its underlying investment vehicles, which may include one or more of the following: mutual funds, collective trust funds and portfolios, which are separately managed exclusively for the benefit of Plan participants and their beneficiaries (separately managed portfolios). The separately managed portfolios are composed primarily of investments in publicly traded common and preferred stocks. The asset classes are designed to provide participants with choices among a variety of investment objectives.
Payments of Benefits
Subject to Plan limitations, upon termination of employment, including termination due to disability (as defined in the Plan) or retirement, a participant may elect to receive a full or partial distribution of his or her account balance in: (a) a single payment in cash; (b) a single distribution in full shares of Amgen stock (with any fractional shares paid in cash); (c) a single distribution paid in a combination of cash and full shares of Amgen stock; or (d) a rollover distribution to an eligible retirement plan.
Participants may also elect to maintain their account balance in the Plan subsequent to termination of employment, provided that their account balance is greater than $1,000.
If a participant dies before receiving the value of his or her account balance, the participant’s beneficiary may elect to receive the distribution of remaining funds from among the alternatives described above, subject to certain Plan limitations.
No withdrawals may be made from the Plan while a participant continues to be employed by the Company except in certain circumstances including, but not limited to, financial hardship, disability and attainment of age 59 1/2.
Notes Receivable from Participants
Subject to certain restrictions, a participant can have up to two loans outstanding at any one time from his or her Plan account with a combined maximum loan amount that may not exceed the lesser of: (a) 50% of the participant’s account balance or (b) $50,000 less certain adjustments, as applicable (as defined in the Plan). A participant’s loan is secured by his or her Plan account balance. Loans bear interest at fixed rates which, until changed by the Company, are based on the prime rate plus one percentage point as published in The Wall Street Journal, determined as of the last day of the calendar quarter preceding origination or such other rate as may be required by law. Loans are generally payable in installments over periods ranging from one to five years, unless the loan is used to acquire a principal residence for which the term of the loan may be up to 20 years. Principal and interest payments are allocated to the participant’s account.


5



The Retirement and Savings Plan for Amgen Manufacturing, Limited
Notes to Financial Statements (continued)

Plan Termination
Although it has not expressed any intent to do so, the Company has the right under the Plan to terminate the Plan subject to the provisions of ERISA. Upon termination, participants would become fully vested in Core Contributions and receive distributions of their account balances.
Trustee and Custodians
Banco Popular de Puerto Rico is the Plan’s trustee. Bank of America, N.A. is the Plan’s custodian with respect to the self-directed brokerage arrangement and the Amgen common stock fund. Northern Trust Company, NA (Northern) is the Plan’s custodian with respect to the asset classes.
2. Summary of Significant Accounting Policies
Basis of Accounting
The accompanying financial statements are prepared on the accrual basis of accounting. Benefits to participants are recorded when paid.
Fair Value Measurement
The investments of the Plan are reported at fair value. Fair value is generally defined as the price that would be received to sell an asset or paid to transfer a liability (the exit price) in an orderly transaction between market participants at the measurement date (see Note 3, Fair Value Measurements).
Investment Income and Losses
Dividend income is recognized on the ex-dividend date, and interest income is recorded on an accrual basis. Unrealized gains and losses on investments are measured by the change in the difference between the fair value and cost of the securities held at the beginning of the year (or date purchased if acquired during the Plan year) and the end of the year. Realized gains and losses from security transactions are recorded based on the weighted-average cost of securities sold.
Notes Receivable from Participants
Notes receivable from participants are carried at their unpaid balance plus accrued but unpaid interest, as applicable.
Due from/to Brokers
Purchases and sales of investments are recorded on a trade-date basis. Amounts due from and due to brokers arise from unsettled sale and purchase transactions, respectively.
Use of Estimates
The preparation of financial statements in conformity with U.S. generally accepted accounting principles (GAAP) requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from those estimates.
Risks and Uncertainties
The Plan provides for investment options representing varied combinations of equities (including Amgen stock), fixed income, and other investments. Investments, in general, particularly in securities, are exposed to various risks, such as interest rate, inflation, market and credit risks, among others. Market risk includes global events which could impact the value of investments, including securities, such as a pandemic or international conflict. Due to the level of risk associated with certain investments, including securities, it is at least reasonably possible that changes in the values of the Plan’s investments, including securities, will occur in the near term and that such changes could materially affect participant account balances and the amounts reported in the Plan’s financial statements.
6



The Retirement and Savings Plan for Amgen Manufacturing, Limited
Notes to Financial Statements (continued)

3. Fair Value Measurements
The Plan uses various valuation approaches in determining the fair value of investments within a hierarchy that maximizes the use of observable inputs and minimizes the use of unobservable inputs by requiring that observable inputs be used when available. Observable inputs are inputs that market participants would use in pricing the investment based on market data obtained from independent sources. Unobservable inputs are inputs that reflect assumptions about the inputs that market participants would use in pricing the investment and are developed based on the best information available in the circumstances. The fair value hierarchy is divided into three levels based on the source of inputs as follows:
Level 1 – Valuations based on unadjusted quoted prices in active markets for identical investments that the Plan has the ability to access;
Level 2 – Valuations for which all significant inputs are observable, either directly or indirectly, other than Level 1 inputs;
Level 3 – Valuations based on inputs that are unobservable and significant to the overall fair value measurement.
The availability of observable inputs can vary among the various types of investments. To the extent that the valuation is based on models or inputs that are less observable or unobservable in the market, the determination of fair value requires more judgment. In certain cases, the inputs used for measuring fair value may fall into different levels of the fair value hierarchy. In such cases, for financial statement disclosure purposes, the level in the fair value hierarchy within which the fair value measurement is categorized is based on the lowest level of input used that is significant to the overall fair value measurement.
The following fair value hierarchy tables present information about each major class/category of the Plan’s investments measured at fair value:
 
Fair value measurements at December 31, 2022, using
 Quoted prices
in active
markets for
identical
assets
(Level 1)
Significant
other
observable
inputs
(Level 2)
Significant
unobservable
inputs
(Level 3)
Total
Amgen stock$103,662,409 $— $— $103,662,409 
Cash and cash equivalents200,285 — — 200,285 
Collective trust funds— 372,729,128 — 372,729,128 
Common and preferred stock101,755,093 — — 101,755,093 
Mutual funds8,345,597 — — 8,345,597 
Self-directed brokerage accounts8,311,430 — — 8,311,430 
Total investments at fair value$222,274,814 $372,729,128 $— $595,003,942 
 
7



The Retirement and Savings Plan for Amgen Manufacturing, Limited
Notes to Financial Statements (continued)

 
Fair value measurements at December 31, 2021, using
 Quoted prices
in  active
markets  for
identical
assets
(Level 1)
Significant
other
observable
inputs
(Level 2)
Significant
unobservable
inputs
(Level 3)
Total
Amgen stock$92,566,483 $— $— $92,566,483 
Cash and cash equivalents4,231,214 — — 4,231,214 
Collective trust funds— 410,998,784 — 410,998,784 
Common and preferred stocks143,456,396 — — 143,456,396 
Mutual funds7,440,054 — — 7,440,054 
Self-directed brokerage accounts11,245,694 — — 11,245,694 
Total investments at fair value$258,939,841 $410,998,784 $— $669,938,625 
The fair values of substantially all common stocks (including Amgen stock), preferred stocks, mutual funds and underlying investments of self-directed brokerage accounts are valued using quoted market prices in active markets with no valuation adjustment.
Collective trust funds represent interests in pooled investment vehicles designed typically for collective investment of employee benefit trusts. The fair values of these investments are determined by reference to the net asset value per unit provided by the fund managers as the basis for current transactions.
4. Income Tax Status
The Plan received an opinion letter from the Puerto Rico Treasury Department (PRTD) dated February 26, 2018, with an effective date of January 1, 2017, stating that the Plan meets the requirements of Section 1081.01 of the PR Code and the regulations thereunder, and, therefore the related trust forming part of the Plan is exempt from taxation. Subsequently, six amendments were made to the Plan, and the Plan received letters from the PRTD stating the PRTD has no objection to the first four of these amendments. The Company has submitted the fifth and sixth amendments to the PRTD requesting an opinion that the Plan remains in compliance with the PR Code and regulations thereunder. Once qualified, the Plan is required to operate in conformity with the PR Code to maintain its qualification.
For taxable year 2022, the Company believes the Plan satisfied, and operated in compliance with, the applicable requirements of the PR Code and therefore believes that the Plan, as amended, is qualified and the related trust is tax exempt. The Company has indicated that it currently intends to continue to take the necessary steps, if any, to maintain the Plan’s compliance with the applicable requirements of the PR Code.
5. Party-in-Interest Transactions
Parties-in-interest are certain entities defined under Department of Labor regulations, including Amgen, and other parties that provide services to the Plan, such as the trustees, custodians and investment managers. The Plan pays the custodians certain administrative and investment management fees, and the Company pays certain administrative fees on behalf of the Plan. The Plan invests in collective trust funds managed by Northern, certain of the Plan’s investment managers and other third parties and may invest in securities of entities that are parties-in-interest. The Plan also invests in shares of common stock of Amgen and receives dividends on those shares. Notes receivable from participants are also considered party-in-interest transactions.
8



The Retirement and Savings Plan for Amgen Manufacturing, Limited
Notes to Financial Statements (continued)

6. Reconciliation of Financial Statements to the Form 5500
The reconciliation of net assets available for benefits per the financial statements to the Form 5500 consisted of the following:
 December 31,
 20222021
Net assets available for benefits per the financial statements$611,006,054 $685,671,780 
Deemed loans(753,247)(672,422)
Net assets per the Form 5500$610,252,807 $684,999,358 
The following is a reconciliation of expenses per the financial statements to the Form 5500:
 Year Ended December 31, 2022
Benefits paid$(35,673,066)
Investment and administrative fees(935,821)
Total expenses per the financial statements(36,608,887)
Deemed loans at December 31, 2021
672,422 
Deemed loans at December 31, 2022
(753,247)
Total expenses per the Form 5500$(36,689,712)
9


Supplemental Schedule
The Retirement and Savings Plan for Amgen Manufacturing, Limited
EIN: 98-0210484 Plan: #001
As of December 31, 2022
Schedule H, line 4i – Schedule of Assets (Held at End of Year)
Identity of IssueDescription of InvestmentCurrent Value
Amgen Stock*Employer Securities 394,694 shares103,662,409 
$103,662,409 
Capital Preservation Asset Class:
Galliard Stable Return Fund W*Collective Trust Fund 1,242,855 units75,788,056 
NT Collective Short Term Investment Fund*Collective Trust Fund 4,223,182 units4,223,182 
Total Capital Preservation Asset Class80,011,238 
Fixed Income Active Asset Class:
MetLife Core Plus Collective Fund*Collective Trust Fund 918,963 units8,546,360 
Wellington Core Bond Plus Portfolio Collective Investment Trust II*Collective Trust Fund 772,168 units8,524,740 
Schroder Global Strategic Bond Trust Class W*Collective Trust Fund 276,029 units2,718,888 
Putnam Absolute Return Fixed Income Fund*Collective Trust Fund 36,931 units2,712,610 
Northern Trust Global Investments Collective Daily Aggregate Bond Index Fund - Non Lending*Collective Trust Fund 792,880 units1,637,983 
Total Fixed Income Active Asset Class24,140,581 
Fixed Income Index Asset Class:
Northern Trust Global Investments Collective Daily Aggregate Bond Index Fund - Non Lending*Collective Trust Fund 792,880 units111,478,898 
Total Fixed Income Index Asset Class111,478,898 
U.S. Equity Active Asset Class:
NT Collective Russell 3000 Index Fund / Non Lending*Collective Trust Fund 79,450 units4,729,549 
Visa Inc. Class A Common and Preferred Stock 13,243 shares2,751,366 
NT Collective Short Term Investment Fund*Collective Trust Fund 2,706,179 units2,706,179 
Amazon Inc.Common and Preferred Stock 29,672 shares2,492,448 
Microsoft CorporationCommon and Preferred Stock 9,195 shares2,205,145 
General ElectricCommon and Preferred Stock 20,569 shares1,723,477 
TransDigm Group Inc.Common and Preferred Stock 1,973 shares1,242,299 
Intuit Inc.Common and Preferred Stock 3,146 shares1,224,486 
Netflix, Inc.Common and Preferred Stock 3,933 shares1,159,763 
Dexcom Inc.Common and Preferred Stock 8,826 shares999,456 
Ball CorporationCommon and Preferred Stock 19,227 shares983,269 
ServiceNow Inc.Common and Preferred Stock 2,355 shares914,376 
The Carlyle Group Inc.Common and Preferred Stock 30,274 shares903,376 
Heico Corporation Class ACommon and Preferred Stock 7,390 shares885,692 
Skechers USA Inc. Class ACommon and Preferred Stock 20,880 shares875,916 
UnitedHealth Group Inc.Common and Preferred Stock 1,638 shares868,435 
Citigroup Inc.Common and Preferred Stock 18,779 shares849,374 
Dow Inc.Common and Preferred Stock 16,518 shares832,342 
10



Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of IssueDescription of InvestmentCurrent Value
Alphabet Inc.Common and Preferred Stock 9,348 shares829,448 
Danaher CorporationCommon and Preferred Stock 3,072 shares815,370 
Skyworks Solutions IncCommon and Preferred Stock 8,841 shares805,680 
Jones Lang LaSalle Inc.Common and Preferred Stock 4,967 shares791,591 
SS&C Technologies Holdings Inc.Common and Preferred Stock 14,665 shares763,460 
Wells Fargo & Company*Common and Preferred Stock 18,435 shares761,181 
Lear CorporationCommon and Preferred Stock 6,118 shares758,754 
KKR & Company Inc. Class ACommon and Preferred Stock 16,245 shares754,093 
Workday Inc. Class ACommon and Preferred Stock 4,494 shares751,981 
Mastercard Inc. Class ACommon and Preferred Stock 2,132 shares741,360 
Qorvo, Inc.Common and Preferred Stock 8,135 shares737,356 
MSCI Inc.Common and Preferred Stock 1,583 shares736,364 
CoStar Group Inc.Common and Preferred Stock 9,424 shares728,287 
Alphabet Inc. Class CCommon and Preferred Stock 8,085 shares717,382 
Yum! Brands Inc.Common and Preferred Stock 5,506 shares705,208 
S&P Global IncCommon and Preferred Stock 2,085 shares698,350 
Equinix Inc.Common and Preferred Stock 1,024 shares670,751 
Thermo Fisher CorporationCommon and Preferred Stock 1,216 shares669,639 
Salesforce.com Inc.Common and Preferred Stock 4,930 shares653,669 
Henry Schein Inc.Common and Preferred Stock 8,184 shares653,656 
Applied Materials Inc.Common and Preferred Stock 6,687 shares651,180 
Ecolab, Inc.Common and Preferred Stock 4,454 shares648,324 
Salesforce.com Inc. Common and Preferred Stock 4,872 shares645,978 
Costar Group Inc. Common and Preferred Stock 8,356 shares645,752 
Merit Medical Systems Inc.Common and Preferred Stock 9,044 shares638,687 
Clean Harbors Inc.Common and Preferred Stock 5,558 shares634,279 
Block, Inc.Common and Preferred Stock 10,093 shares634,244 
Cognizant Technology Solutions Corporation Class ACommon and Preferred Stock 10,999 shares629,033 
Match Group Inc.Common and Preferred Stock 14,797 shares613,928 
Fresenius Medical CareCommon and Preferred Stock 37,471 shares612,276 
QuidelOrtho CorporationCommon and Preferred Stock 7,007 shares600,290 
STERIS plcCommon and Preferred Stock 3,225 shares595,625 
Wabtec CorporationCommon and Preferred Stock 5,920 shares590,875 
Newell Brands Inc.Common and Preferred Stock 45,083 shares589,686 
Edison InternationalCommon and Preferred Stock 9,266 shares589,503 
Autodesk Inc.Common and Preferred Stock 3,119 shares582,848 
Iqvia Holdings Inc.Common and Preferred Stock 2,830 shares579,839 
Waste Connections Inc.Common and Preferred Stock 4,368 shares579,022 
Regeneron Pharmaceuticals, Inc.Common and Preferred Stock 798 shares575,749 
Intuitive Surgical, Inc. Common and Preferred Stock 2,150 shares570,503 
MetLife Inc.*Common and Preferred Stock 7,881 shares570,348 
Sherwin-Williams CompanyCommon and Preferred Stock 2,353 shares558,437 
Halozyme Therapeutics Inc.Common and Preferred Stock 9,782 shares556,596 
Capital One Financial CorporationCommon and Preferred Stock 5,899 shares548,371 
Equitable Holdings Inc.Common and Preferred Stock 18,950 shares543,865 
Ares Management CorporationCommon and Preferred Stock 7,846 shares536,980 
FMC CorporationCommon and Preferred Stock 4,172 shares520,666 
CBRE Group Inc. Class ACommon and Preferred Stock 6,732 shares518,095 
Anthem Inc.Common and Preferred Stock 1,009 shares517,587 
Ritchie Bros Auctioneers Inc.Common and Preferred Stock 8,945 shares517,289 
Synopsys Inc.Common and Preferred Stock 1,610 shares514,057 
11



Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of IssueDescription of InvestmentCurrent Value
NICE LimitedCommon and Preferred Stock 2,649 shares509,403 
Voya Financial Inc.Common and Preferred Stock 8,159 shares501,697 
Aon PLCCommon and Preferred Stock 1,671 shares501,534 
Lam Research CorporationCommon and Preferred Stock 1,168 shares490,910 
American Express CompanyCommon and Preferred Stock 3,322 shares490,826 
Ametek Inc.Common and Preferred Stock 3,510 shares490,417 
Starbucks Corporation Common and Preferred Stock 4,919 shares487,965 
Charles River Laboratories International Inc.Common and Preferred Stock 2,234 shares486,789 
FleetCor Technologies Inc.Common and Preferred Stock 2,630 shares483,078 
JP Morgan Chase & CompanyCommon and Preferred Stock 3,600 shares482,760 
Booking Holdings Inc.Common and Preferred Stock 233 shares469,560 
Sensata Technologies BV HoldingCommon and Preferred Stock 11,485 shares463,764 
Gildan Activewear Inc.Common and Preferred Stock 16,718 shares458,073 
Adobe Systems Inc. Common and Preferred Stock 1,335 shares449,268 
Amdocs LimitedCommon and Preferred Stock 4,903 shares445,683 
Shopify IncCommon and Preferred Stock 12,798 shares444,219 
American International Group Inc.Common and Preferred Stock 6,919 shares437,558 
Bristol Myers SquibbCommon and Preferred Stock 6,035 shares434,218 
Amphenol Corporation Class ACommon and Preferred Stock 5,490 shares418,009 
Frontdoor Inc.Common and Preferred Stock 19,642 shares408,554 
Uber Technologies Inc.Common and Preferred Stock 16,491 shares407,822 
Alight Inc. Class ACommon and Preferred Stock 48,658 shares406,781 
Warner Music Group Corporation Class ACommon and Preferred Stock 11,572 shares405,251 
J2 Global Inc.Common and Preferred Stock 5,122 shares405,150 
Atlassian CorporationCommon and Preferred Stock 3,117 shares401,096 
Axis Capital Holdings LimitedCommon and Preferred Stock 7,397 shares400,695 
Dollar General CorporationCommon and Preferred Stock 1,619 shares398,679 
BWX Technologies Inc.Common and Preferred Stock 6,825 shares396,396 
IDEX CorporationCommon and Preferred Stock 1,698 shares387,704 
NOV Inc.Common and Preferred Stock 18,554 shares387,593 
Hewlett Packard Enterprise CompanyCommon and Preferred Stock 24,135 shares385,195 
Euronet Worldwide Inc.Common and Preferred Stock 4,080 shares385,070 
Bank of America Corporation*Common and Preferred Stock 11,404 shares377,700 
Align Technology Inc.Common and Preferred Stock 1,789 shares377,300 
Snowflake Inc. Class ACommon and Preferred Stock 2,608 shares374,352 
Catalent Inc.Common and Preferred Stock 8,225 shares370,207 
Floor & Decor Holdings Inc.Common and Preferred Stock 5,315 shares370,083 
Lam Resh CorporationCommon and Preferred Stock 877 shares368,603 
LKQ CorporationCommon and Preferred Stock 6,889 shares367,941 
Entegris Inc.Common and Preferred Stock 5,570 shares365,336 
UGI CorporationCommon and Preferred Stock 9,829 shares364,361 
PVH CorporationCommon and Preferred Stock 5,103 shares360,221 
Abbott LaboratoriesCommon and Preferred Stock 3,137 shares344,411 
Halliburton CompanyCommon and Preferred Stock 8,619 shares339,158 
Ingredion Inc.Common and Preferred Stock 3,439 shares336,781 
HealthEquity Inc.Common and Preferred Stock 5,428 shares334,582 
Huntington Bancshares Inc.Common and Preferred Stock 23,452 shares330,673 
Acadia Healthcare Company Inc.Common and Preferred Stock 3,899 shares320,966 
Cloudflare Inc.Common and Preferred Stock 7,025 shares317,600 
Churchill Downs Inc.Common and Preferred Stock 1,465 shares309,745 
Datadog Inc.Common and Preferred Stock 4,214 shares309,729 
12



Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of IssueDescription of InvestmentCurrent Value
Sarepta Therapeutics Inc.Common and Preferred Stock 2,341 shares303,347 
Trimble Inc.Common and Preferred Stock 5,978 shares302,248 
Brown & Brown Inc.Common and Preferred Stock 5,295 shares301,656 
Mohawk Industries Inc.Common and Preferred Stock 2,945 shares301,038 
Cabot CorporationCommon and Preferred Stock 4,468 shares298,641 
Cooper Companies Inc.Common and Preferred Stock 890 shares294,296 
National Retail Properties Inc.Common and Preferred Stock 6,332 shares289,752 
GlobalFoundries Inc.Common and Preferred Stock 5,277 shares284,378 
ACV Auctions Inc. Class ACommon and Preferred Stock 34,326 shares281,816 
On Semiconductor CorporationCommon and Preferred Stock 4,496 shares280,416 
Goldman Sachs Group Inc.Common and Preferred Stock 807 shares277,108 
Dycom Industries Inc.Common and Preferred Stock 2,883 shares269,849 
Western Alliance BancorporationCommon and Preferred Stock 4,491 shares267,484 
Momentive Global Inc.Common and Preferred Stock 37,986 shares265,902 
Carter Inc.Common and Preferred Stock 3,550 shares264,866 
FTI Consulting Inc.Common and Preferred Stock 1,664 shares264,243 
Forward Air CorporationCommon and Preferred Stock 2,493 shares261,491 
Tennant CompanyCommon and Preferred Stock 4,242 shares261,180 
MACOM Technology Solutions Holdings Inc.Common and Preferred Stock 4,131 shares260,170 
Keysight Technologies Inc.Common and Preferred Stock 1,472 shares251,815 
Gartner Inc.Common and Preferred Stock 747 shares251,097 
DoorDash Inc. Class ACommon and Preferred Stock 5,016 shares244,881 
Nvidia CorporationCommon and Preferred Stock 1,661 shares242,739 
ZipRecruiter Inc. Class ACommon and Preferred Stock 14,536 shares238,681 
Huron Consulting Group Inc.Common and Preferred Stock 3,249 shares235,877 
NRG Energy Inc.Common and Preferred Stock 7,361 shares234,227 
AerCap Holdings N.V.Common and Preferred Stock 3,972 shares231,647 
KAR Auction Services Inc.Common and Preferred Stock 17,586 shares229,497 
Belden Inc.Common and Preferred Stock 3,117 shares224,112 
BankUnited Inc.Common and Preferred Stock 6,543 shares222,266 
Sea LimitedCommon and Preferred Stock 4,249 shares221,075 
N-Able Technologies International Inc.Common and Preferred Stock 21,491 shares220,927 
CarGurus Inc. Class ACommon and Preferred Stock 15,757 shares220,756 
National Bank Holdings Corporation Class ACommon and Preferred Stock 5,109 shares214,936 
LPL Financial Holdings Inc.Common and Preferred Stock 994 shares214,873 
Chemed CorporationCommon and Preferred Stock 416 shares212,339 
UBS Group AGCommon and Preferred Stock 11,334 shares211,606 
Albany International Corporation Class ACommon and Preferred Stock 2,133 shares210,292 
ALLETE Inc.Common and Preferred Stock 3,257 shares210,109 
Altra Industrial Motion CorporationCommon and Preferred Stock 3,506 shares209,484 
Advanced Energy Industries Inc.Common and Preferred Stock 2,439 shares209,217 
Certara Inc.Common and Preferred Stock 12,861 shares206,676 
Magna International Inc.Common and Preferred Stock 3,673 shares206,349 
KBR, Inc.Common and Preferred Stock 3,904 shares206,131 
Pfizer Inc.Common and Preferred Stock 4,022 shares206,087 
Edwards Lifesciences CorporationCommon and Preferred Stock 2,698 shares201,298 
Prosperity Bancshares Inc.Common and Preferred Stock 2,759 shares200,524 
ASGN Inc.Common and Preferred Stock 2,428 shares197,833 
Bio-Techne CorporationCommon and Preferred Stock 2,379 shares197,172 
Sally Beauty Holdings Inc.Common and Preferred Stock 15,576 shares195,012 
Trinet Group Inc.Common and Preferred Stock 2,830 shares191,874 
13



Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of IssueDescription of InvestmentCurrent Value
Nasdaq Inc.Common and Preferred Stock 3,077 shares188,774 
Graphic Packaging Holding CompanyCommon and Preferred Stock 8,429 shares187,545 
Cardinal Health, Inc.Common and Preferred Stock 2,414 shares185,564 
Teleflex Inc.Common and Preferred Stock 742 shares185,225 
Carlisle Companies Inc.Common and Preferred Stock 784 shares184,750 
Monday.com LimitedCommon and Preferred Stock 1,509 shares184,098 
Kirby CorporationCommon and Preferred Stock 2,857 shares183,848 
WillScot Mobile Mini Holdings CorporationCommon and Preferred Stock 4,062 shares183,481 
McKesson CorporationCommon and Preferred Stock 483 shares181,183 
Range Resources CorporationCommon and Preferred Stock 7,153 shares178,968 
Box Inc. Class ACommon and Preferred Stock 5,736 shares178,562 
Smartsheet Inc. Class ACommon and Preferred Stock 4,518 shares177,828 
Matson Inc.Common and Preferred Stock 2,840 shares177,528 
Shell plcCommon and Preferred Stock 3,111 shares177,171 
Charter Communications, Inc. Class ACommon and Preferred Stock 519 shares175,993 
Copart Inc.Common and Preferred Stock 2,879 shares175,302 
First American Financial CorporationCommon and Preferred Stock 3,327 shares174,135 
Northern Trust Interest Bearing Cash* Cash and Cash Equivalents 173,146 units173,146 
Supernus Pharmaceuticals Inc.Common and Preferred Stock 4,832 shares172,357 
WisdomTree Investments Inc.Common and Preferred Stock 31,440 shares171,348 
Signature BankCommon and Preferred Stock 1,480 shares170,526 
Diamondback Energy Inc.Common and Preferred Stock 1,214 shares166,051 
Dolby Laboratories Inc.Common and Preferred Stock 2,353 shares165,981 
Graco Inc.Common and Preferred Stock 2,436 shares163,845 
Airbnb Inc. Class ACommon and Preferred Stock 1,912 shares163,476 
Barnes Group Inc.Common and Preferred Stock 3,976 shares162,420 
Itron Inc.Common and Preferred Stock 3,088 shares156,407 
Cohen & Steers Inc.Common and Preferred Stock 2,421 shares156,300 
Under Armour Inc. Class CCommon and Preferred Stock 17,492 shares156,029 
Woodward Inc.Common and Preferred Stock 1,596 shares154,190 
AptarGroup Inc.Common and Preferred Stock 1,399 shares153,862 
Mednax Inc.Common and Preferred Stock 10,339 shares153,638 
Grand Canyon Education Inc.Common and Preferred Stock 1,421 shares150,143 
Okta Inc.Common and Preferred Stock 2,156 shares147,319 
Prestige Consumer Healthcare Inc.Common and Preferred Stock 2,345 shares146,797 
Oceaneering International Inc.Common and Preferred Stock 8,251 shares144,310 
Dynatrace Inc.Common and Preferred Stock 3,731 shares142,897 
Alamos Gold Inc. Class ACommon and Preferred Stock 13,941 shares140,944 
Generac Holdings Inc.Common and Preferred Stock 1,396 shares140,521 
Veracyte Inc.Common and Preferred Stock 5,896 shares139,912 
Encompass Health CorporationCommon and Preferred Stock 2,321 shares138,819 
BRP Group Inc. Class ACommon and Preferred Stock 5,498 shares138,220 
NexTier Oilfield Solutions Inc.Common and Preferred Stock 14,847 shares137,186 
Monro Inc.Common and Preferred Stock 3,025 shares136,730 
Knowles CorporationCommon and Preferred Stock 8,186 shares134,414 
Markel Corporation Holding CompanyCommon and Preferred Stock 102 shares134,384 
TreeHouse Foods Inc.Common and Preferred Stock 2,710 shares133,820 
Consensus Cloud Solutions Inc. Common and Preferred Stock 2,430 shares130,637 
ACI Worldwide Inc.Common and Preferred Stock 5,669 shares130,387 
Teledyne Technologies Inc.Common and Preferred Stock 325 shares129,971 
10X Genomics Inc. Class A Common and Preferred Stock 3,560 shares129,726 
14



Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of IssueDescription of InvestmentCurrent Value
Hexcel CorporationCommon and Preferred Stock 2,182 shares128,411 
Tronox Holdings PLCCommon and Preferred Stock 9,262 shares126,982 
John Bean Technologies CorporationCommon and Preferred Stock 1,375 shares125,579 
Matthews International Corporation Class ACommon and Preferred Stock 4,097 shares124,713 
SpringWorks Therapeutics Inc.Common and Preferred Stock 4,670 shares121,467 
Ciena CorporationCommon and Preferred Stock 2,380 shares121,332 
United Community Bank Blairsville GeorgiaCommon and Preferred Stock 3,588 shares121,274 
Texas Capital Bancshares Inc.Common and Preferred Stock 1,997 shares120,439 
Knight-Swift Transportation Holdings Inc. Class ACommon and Preferred Stock 2,296 shares120,333 
Helen Trustoy LimitedCommon and Preferred Stock 1,084 shares120,226 
Jacobs Solutions Inc.Common and Preferred Stock 985 shares118,269 
Hanesbrands Inc.Common and Preferred Stock 18,223 shares115,898 
Pacific Premier Bancorp Inc.Common and Preferred Stock 3,669 shares115,794 
Agios Pharmaceuticals Inc.Common and Preferred Stock 4,120 shares115,690 
Nu Skin Enterprises Inc. Class ACommon and Preferred Stock 2,736 shares115,350 
Nevro CorporationCommon and Preferred Stock 2,855 shares113,058 
C.H. Robinson Worldwide Inc.Common and Preferred Stock 1,218 shares111,520 
NCR CorporationCommon and Preferred Stock 4,743 shares111,034 
Canada Goose Holdings Inc.Common and Preferred Stock 6,176 shares109,995 
World Wrestling EntertainmentCommon and Preferred Stock 1,603 shares109,838 
8X8 Inc.Common and Preferred Stock 24,905 shares107,590 
JBG SMITH PropertiesCommon and Preferred Stock 5,623 shares106,725 
Coherent CorporationCommon and Preferred Stock 3,037 shares106,599 
Cimpress plcCommon and Preferred Stock 3,820 shares105,470 
Sportradar GroupCommon and Preferred Stock 10,499 shares104,570 
Legend Biotech CorporationCommon and Preferred Stock 2,069 shares103,284 
Docusign Inc.Common and Preferred Stock 1,862 shares103,192 
Summit Materials Inc.Common and Preferred Stock 3,635 shares103,191 
SLR Investment CorporationCommon and Preferred Stock 7,395 shares102,864 
Aspen Technology Inc.Common and Preferred Stock 472 shares96,949 
CareDx Inc.Common and Preferred Stock 8,482 shares96,780 
Azekpany Inc.Common and Preferred Stock 4,640 shares94,285 
Qualtrics International Inc.Common and Preferred Stock 9,078 shares94,230 
Haemonetics CorporationCommon and Preferred Stock 1,170 shares92,021 
IAA Spinco Inc.Common and Preferred Stock 2,264 shares90,560 
iShares Russell Mid-Cap ETFMutual Fund 1,340 units90,383 
J & J Snack Foods CorporationCommon and Preferred Stock 603 shares90,275 
Mid-American Apartment Communities Inc.Common and Preferred Stock 573 shares89,955 
PacWest BancorpCommon and Preferred Stock 3,818 shares87,623 
Sumo Logic Inc.Common and Preferred Stock 10,650 shares86,265 
Sotera Health CompanyCommon and Preferred Stock 10,125 shares84,341 
AZZ Inc.Common and Preferred Stock 2,095 shares84,219 
Arvinas Inc.Common and Preferred Stock 2,458 shares84,088 
Northwestern CorporationCommon and Preferred Stock 1,400 shares83,076 
Farfetch Limited Class ACommon and Preferred Stock 17,511 shares82,827 
Infinera CorporationCommon and Preferred Stock 12,063 shares81,305 
Silgan Holdings Inc.Common and Preferred Stock 1,552 shares80,456 
Omnicell Inc.Common and Preferred Stock 1,541 shares77,697 
Flowserve CorporationCommon and Preferred Stock 2,530 shares77,620 
Wolverine World Wide Inc.Common and Preferred Stock 7,070 shares77,275 
Middleby CorporationCommon and Preferred Stock 575 shares76,993 
15



Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of IssueDescription of InvestmentCurrent Value
Tenable Holdings Inc.Common and Preferred Stock 2,011 shares76,720 
Relay Therapeutics Inc.Common and Preferred Stock 5,078 shares75,865 
Harsco CorporationCommon and Preferred Stock 11,957 shares75,210 
IPG Photonics CorporationCommon and Preferred Stock 783 shares74,127 
KB HomeCommon and Preferred Stock 2,273 shares72,395 
iShares Core S&P Small-Cap ETFMutual Fund 754 units71,359 
Doximity Inc.Common and Preferred Stock 2,092 shares70,208 
C4 Therapeutics Inc. Common and Preferred Stock 11,878 shares70,080 
Herbalife Nutrition LimitedCommon and Preferred Stock 4,671 shares69,504 
Banner CorporationCommon and Preferred Stock 1,089 shares68,825 
Rocket Lab USA Inc.Common and Preferred Stock 18,208 shares68,644 
1-800-FLOWERS.COM Inc. Class ACommon and Preferred Stock 7,102 shares67,895 
Axogen Inc.Common and Preferred Stock 6,787 shares67,734 
STAG Industrial Inc.Common and Preferred Stock 2,083 shares67,302 
WSFS Financial CorporationCommon and Preferred Stock 1,483 shares67,239 
Fox Factory Holding CorporationCommon and Preferred Stock 732 shares66,780 
Coherus BioSciences Inc.Common and Preferred Stock 8,220 shares65,102 
Albemarle CorporationCommon and Preferred Stock 298 shares64,624 
Sonos Inc.Common and Preferred Stock 3,759 shares63,527 
Boston Properties Inc.Common and Preferred Stock 896 shares60,552 
Mercury Systems Inc.Common and Preferred Stock 1,351 shares60,444 
Designer Brands Inc. Class ACommon and Preferred Stock 6,048 shares59,149 
Heartland Express Inc.Common and Preferred Stock 3,678 shares56,421 
Berkshire Hills Bancorp Inc.Common and Preferred Stock 1,723 shares51,518 
CalAmp CorporationCommon and Preferred Stock 10,489 shares46,991 
PetIQ Inc. Class ACommon and Preferred Stock 4,839 shares44,616 
Stevanato Group S.p.A.Common and Preferred Stock 2,349 shares42,212 
Adeia Inc.Common and Preferred Stock 4,022 shares38,129 
iShares Russell 2000 ETFMutual Fund 215 units37,487 
Rogers CorporationCommon and Preferred Stock 268 shares31,983 
Sterling Check CorporationCommon and Preferred Stock 2,014 shares31,157 
Istar Inc.Common and Preferred Stock 3,418 shares26,079 
Enhabit Inc.Common and Preferred Stock 1,160 shares15,266 
eHealth Inc.Common and Preferred Stock 2,234 shares10,813 
Safehold Inc.Common and Preferred Stock 261 shares7,470 
Total U.S. Equity Active Asset Class109,563,201 
U.S. Equity Index Asset Class:
NT Collective Russell 3000 Index Fund / Non Lending*Collective Trust Fund 1,301,755 units77,492,154 
Total U.S. Equity Index Asset Class77,492,154 
International Equity Active Asset Class:
Mawer International Equity Collective Investment Trust Class B*Collective Trust Fund 1,003,963 units14,314,907 
Polaris Capital Management Collective Investment Trust International Value Collective Fund*Collective Trust Fund 1,420,400 units14,170,766 
Reliance Trust Institutional Retirement Trust GQG Partners International Equity Fund Series 11 Class C*Collective Trust Fund 886,595 units10,887,388 
Dodge & Cox International Fund*Mutual Fund 188,967 units8,146,368 
16



Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of IssueDescription of InvestmentCurrent Value
Wilmington Trust Collective Investment Trust / Jennison International Equity Opportunities CIT Class J*Collective Trust Fund 1,023,424 units7,870,129 
NT Collective MSCI All Country World Index (ACWI) ex/US Index Fund / Non Lending*Collective Trust Fund 17,529 units3,243,062 
Total International Equity Active Asset Class58,632,620 
International Equity Index Asset Class:
NT Collective MSCI All Country World Index (ACWI) ex/US Index Fund /Non Lending (Tier J)*Collective Trust Fund 128,332 units21,674,049 
BlackRock FTSE RAFI Emerging Index Non Lendable Fund FCollective Trust Fund 1,675 units8,859 
Total International Equity Index Asset Class21,682,908 
Participant Self-Directed AccountsVarious Investments8,311,430 
8,311,430 
Notes Receivable from Participants*Interest Rate 4.25% - 9.25%15,315,527 
15,315,527 
Other:
Vanguard Federal Money MarketCash and Cash Equivalents 27,135 units27,135 
NT Collective Short Term Investment Fund*Collective Trust Fund 526,957 units1,368 
Total Other28,503 
Grand Total$610,319,469 
* Indicates party-in-interest

17


THE RETIREMENT AND SAVINGS PLAN FOR
AMGEN MANUFACTURING, LIMITED
INDEX TO EXHIBIT
 
  Exhibit 23.1
18


SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the trustees (or other persons who administer the employee benefit plan) have duly caused this annual report to be signed on its behalf by the undersigned hereunto duly authorized.
 
  
 The Retirement and Savings Plan for
 Amgen Manufacturing, Limited
 (Name of Plan)
Date:June 14, 2023 By: /s/ PETER H. GRIFFITH
   Peter H. Griffith
   
Deputy Chairman and Chief Financial Officer
Amgen Manufacturing, Limited
19
Document


Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We consent to the incorporation by reference in the Registration Statements (Form S-8 Nos. 33-47605, 333-144580 and 333-216715) pertaining to The Retirement and Savings Plan for Amgen Manufacturing, Limited of Amgen Inc. of our report dated June 14, 2023, with respect to the financial statements and schedule of The Retirement and Savings Plan for Amgen Manufacturing, Limited included in this Annual Report (Form 11-K) for the year ended December 31, 2022.

/s/ ERNST & YOUNG LLP
Los Angeles, California
June 14, 2023