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  <xsd:element id="amgn_NumberofPartneredOncologyAssets" name="NumberofPartneredOncologyAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="amgn_OnyxPharmaceuticalsInc.Member" name="OnyxPharmaceuticalsInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_OtherComprehensiveIncomeLossOtherGainsLossesNetOfTaxPortionAttributableToParent" name="OtherComprehensiveIncomeLossOtherGainsLossesNetOfTaxPortionAttributableToParent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="amgn_OtherComprehensiveIncomeOtherTax" name="OtherComprehensiveIncomeOtherTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="amgn_OtherComprehensiveIncomeReclassificationAdjustmentToIncomeBeforeTax" name="OtherComprehensiveIncomeReclassificationAdjustmentToIncomeBeforeTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="amgn_OtherComprehensiveIncomeUnrealizedArisingDuringPeriodBeforeReclassificationsAndTaxOthers" name="OtherComprehensiveIncomeUnrealizedArisingDuringPeriodBeforeReclassificationsAndTaxOthers" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_OtherCurrentNoncurrentAssetsMember" name="OtherCurrentNoncurrentAssetsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_OtherGovernmentRelatedAndCorporateDebtSecuritiesMember" name="OtherGovernmentRelatedAndCorporateDebtSecuritiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_OtherNotes" name="OtherNotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="amgn_OtherShortTermInterestBearingSecuritiesMember" name="OtherShortTermInterestBearingSecuritiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_PaySideMember" name="PaySideMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_PaymentByCapitalizationDomain" name="PaymentByCapitalizationDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_PaymentstoAcquireBusinessesandAcceleratedEquityAwards" name="PaymentstoAcquireBusinessesandAcceleratedEquityAwards" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_PuertoRicoExciseTaxMember" name="PuertoRicoExciseTaxMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_RateAdjustmentToLiborOnInterestRateSwapAgreementsMember" name="RateAdjustmentToLiborOnInterestRateSwapAgreementsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ReceiveSideMember" name="ReceiveSideMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeLineItems" name="ReclassificationOutOfAccumulatedOtherComprehensiveIncomeLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ReclassificationsOutOfAccumulatedOtherComprehensiveIncomeTableTextBlock" name="ReclassificationsOutOfAccumulatedOtherComprehensiveIncomeTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_RestrictedInterestReceivable" name="RestrictedInterestReceivable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="amgn_RestrictedInvestmentsPolicyTextBlock" name="RestrictedInvestmentsPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ScheduleOfIntangibleAssetsTableTextBlock" name="ScheduleOfIntangibleAssetsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ScheduleOfNotionalAmountsAndInterestRatesForCrossCurrencySwapsTableTextBlock" name="ScheduleOfNotionalAmountsAndInterestRatesForCrossCurrencySwapsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_StatementsOfIncomeAndAmountOfGainRecognizedInIncomeForDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsTableTextBlock" name="StatementsOfIncomeAndAmountOfGainRecognizedInIncomeForDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_StatementsOfIncomeAndEffectivePortionOfGainLossReclassifiedFromAccumulatedOtherComprehensiveIncomeIntoIncomeForOurCashFlowHedgeContractsTableTextBlock" name="StatementsOfIncomeAndEffectivePortionOfGainLossReclassifiedFromAccumulatedOtherComprehensiveIncomeIntoIncomeForOurCashFlowHedgeContractsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TermLoanDueTwoThousandEighteenMember" name="TermLoanDueTwoThousandEighteenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointSixTwoFivePercentNoteDueTwoZeroTwoTwoMember" name="ThreePointSixTwoFivePercentNoteDueTwoZeroTwoTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointOneTwoFivePercentNoteDueTwoZeroOneSevenMember" name="TwoPointOneTwoFivePercentNoteDueTwoZeroOneSevenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_UnrealizedLossesGainsBeforeReclassifications" name="UnrealizedLossesGainsBeforeReclassifications" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
</xsd:schema>
