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  <xsd:element id="amgn_RestructuringandRelatedCostExpectedCostAcceleratedDepreciationandAssetImpairmentChargesandOtherCosts" name="RestructuringandRelatedCostExpectedCostAcceleratedDepreciationandAssetImpairmentChargesandOtherCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="amgn_RestructuringandRelatedCostExpectedCostSeparationCosts" name="RestructuringandRelatedCostExpectedCostSeparationCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="amgn_ScheduleOfIntangibleAssetsTableTextBlock" name="ScheduleOfIntangibleAssetsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ScheduleOfNotionalAmountsAndInterestRatesForCrossCurrencySwapsTableTextBlock" name="ScheduleOfNotionalAmountsAndInterestRatesForCrossCurrencySwapsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ScheduleofLongtermDebtInstrumentsExchangedTableTextBlock" name="ScheduleofLongtermDebtInstrumentsExchangedTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SeparationandOtherHeadcountrelatedCostsMember" name="SeparationandOtherHeadcountrelatedCostsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SixPointFourZeroPercentNotesDue2039Member" name="SixPointFourZeroPercentNotesDue2039Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SixPointNineZeroPercentNotesDue2038Member" name="SixPointNineZeroPercentNotesDue2038Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SixPointOneFivePercentNotesDueTwoZeroOneEightMember" name="SixPointOneFivePercentNotesDueTwoZeroOneEightMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SixPointThreeSevenFivePercentNotesDue2037Member" name="SixPointThreeSevenFivePercentNotesDue2037Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_StatementsOfIncomeAndAmountOfGainRecognizedInIncomeForDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsTableTextBlock" name="StatementsOfIncomeAndAmountOfGainRecognizedInIncomeForDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_StatementsOfIncomeAndEffectivePortionOfGainLossReclassifiedFromAccumulatedOtherComprehensiveIncomeIntoIncomeForOurCashFlowHedgeContractsTableTextBlock" name="StatementsOfIncomeAndEffectivePortionOfGainLossReclassifiedFromAccumulatedOtherComprehensiveIncomeIntoIncomeForOurCashFlowHedgeContractsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_StockRepurchaseProgramTableTextBlock" name="StockRepurchaseProgramTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TermLoanDueTwoThousandEighteenMember" name="TermLoanDueTwoThousandEighteenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TermLoanMember" name="TermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointEightSevenFivePercentNotesDueTwoZeroTwoOneMember" name="ThreePointEightSevenFivePercentNotesDueTwoZeroTwoOneMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointFourFivePercentNotesDueTwoZeroTwoZeroMember" name="ThreePointFourFivePercentNotesDueTwoZeroTwoZeroMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointOneTwoFivePercentNotesDueTwoZeroTwoFiveMember" name="ThreePointOneTwoFivePercentNotesDueTwoZeroTwoFiveMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointSixTwentyFivePercentNotesDueTwoThousandTwentyFourMember" name="ThreePointSixTwentyFivePercentNotesDueTwoThousandTwentyFourMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointSixTwoFivePercentNoteDueTwoZeroTwoTwoMember" name="ThreePointSixTwoFivePercentNoteDueTwoZeroTwoTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPercentEuroNotesDueTwoThousandTwentySixMember" name="TwoPercentEuroNotesDueTwoThousandTwentySixMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointFiveZeroPercentNotesDueTwoZeroOneSixMember" name="TwoPointFiveZeroPercentNotesDueTwoZeroOneSixMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointOneTwoFivePercentNoteDueTwoZeroOneSevenMember" name="TwoPointOneTwoFivePercentNoteDueTwoZeroOneSevenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointOneTwoFivePercentNotesDueTwoZeroTwoZeroMember" name="TwoPointOneTwoFivePercentNotesDueTwoZeroTwoZeroMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointSevenZeroPercentNotesDueTwoZeroTwoTwoMember" name="TwoPointSevenZeroPercentNotesDueTwoZeroTwoTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointThreeZeroPercentNotesDueTwoZeroOneSixMember" name="TwoPointThreeZeroPercentNotesDueTwoZeroOneSixMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointTwentyPercentNotesDueTwoThousandNineteenMember" name="TwoPointTwentyPercentNotesDueTwoThousandNineteenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ZeroPointFortyOnePercentSwissFrancBondsDueTwoThousandTwentyThreeMember" name="ZeroPointFortyOnePercentSwissFrancBondsDueTwoThousandTwentyThreeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
</xsd:schema>
