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Disclosure - Summary of significant accounting policies link:presentationLink link:calculationLink link:definitionLink 220022001 - Disclosure - Summary of significant accounting policies - (Policies) link:presentationLink link:calculationLink link:definitionLink 240034001 - Disclosure - Summary of significant accounting policies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 210041002 - Disclosure - Acquisitions link:presentationLink link:calculationLink link:definitionLink 230053001 - Disclosure - Acquisitions - (Tables) link:presentationLink link:calculationLink link:definitionLink 240064002 - Disclosure - Acquisitions - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 240074003 - Disclosure - Acquisitions - Otezla (Details) link:presentationLink link:calculationLink link:definitionLink 240084004 - Disclosure - Acquisitions - Aggregate Consideration Paid (Details) link:presentationLink link:calculationLink link:definitionLink 210091003 - Disclosure - Revenues link:presentationLink link:calculationLink link:definitionLink 230103002 - Disclosure - Revenues (Tables) link:presentationLink link:calculationLink link:definitionLink 240114005 - Disclosure - Revenues - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 240124006 - Disclosure - Revenues - Customer Concentration, Product Sales (Details) link:presentationLink link:calculationLink link:definitionLink 210131004 - Disclosure - Stock-based compensation link:presentationLink link:calculationLink link:definitionLink 230143003 - Disclosure - Stock-based compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 240154007 - Disclosure - Stock-based compensation (Textual) (Details) link:presentationLink link:calculationLink link:definitionLink 240164008 - Disclosure - Stock-based compensation (Components of Stock-based Compensation Expense) (Details) link:presentationLink link:calculationLink link:definitionLink 240174009 - Disclosure - Stock-based compensation (Summary of RSUs) (Details) link:presentationLink link:calculationLink link:definitionLink 240184010 - Disclosure - Stock-based compensation Stock-based compensation (Summary of Stock Options) (Details) link:presentationLink link:calculationLink link:definitionLink 240194011 - Disclosure - Stock-based compensation (Summary of Stock Options) (Details) link:presentationLink link:calculationLink link:definitionLink 240204012 - Disclosure - Stock-based compensation (Weighted-average Assumptions) (Details) link:presentationLink link:calculationLink link:definitionLink 210211005 - Disclosure - Defined contribution plan link:presentationLink link:calculationLink link:definitionLink 240224013 - Disclosure - Defined contribution plan (Details) link:presentationLink link:calculationLink link:definitionLink 210231006 - Disclosure - Income taxes link:presentationLink link:calculationLink link:definitionLink 230243004 - Disclosure - Income taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 240254014 - 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Earnings per share (Tables) link:presentationLink link:calculationLink link:definitionLink 240334020 - Disclosure - Earnings per share (Details) link:presentationLink link:calculationLink link:definitionLink 210341008 - Disclosure - Collaborations link:presentationLink link:calculationLink link:definitionLink 240354021 - Disclosure - Collaborations - Novartis AG (Details) link:presentationLink link:calculationLink link:definitionLink 240364022 - Disclosure - Collaborations - Bayer HealthCare Pharmaceuticals Inc. 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Disclosure - Goodwill and intangible assets link:presentationLink link:calculationLink link:definitionLink 230553009 - Disclosure - Goodwill and other intangible assets - (Tables) link:presentationLink link:calculationLink link:definitionLink 240564034 - Disclosure - Goodwill and other intangible assets - Goodwill Roll Forward (Details) link:presentationLink link:calculationLink link:definitionLink 240574035 - Disclosure - Goodwill and other intangible assets - Identifiable Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 240584036 - Disclosure - Goodwill and other intangible assets - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 210591013 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 230603010 - Disclosure - Leases - (Tables) link:presentationLink link:calculationLink link:definitionLink 240614037 - Disclosure - Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 240624038 - 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Disclosure - Financing arrangements (Shelf Registration Statements and Other Facilities) (Details) link:presentationLink link:calculationLink link:definitionLink 240774049 - Disclosure - Financing arrangements (Contractual Maturities of Long-term Debt) (Details) link:presentationLink link:calculationLink link:definitionLink 240784050 - Disclosure - Financing arrangements (Interest Costs) (Details) link:presentationLink link:calculationLink link:definitionLink 210791016 - Disclosure - Stockholders' equity link:presentationLink link:calculationLink link:definitionLink 230803013 - Disclosure - Stockholders' equity (Tables) link:presentationLink link:calculationLink link:definitionLink 240814051 - Disclosure - Stockholders' equity (Stock Repurchase Program) (Details) link:presentationLink link:calculationLink link:definitionLink 240824052 - Disclosure - Stockholders' equity (Dividends) (Details) link:presentationLink link:calculationLink link:definitionLink 240834053 - Disclosure - Stockholders' equity (Components of AOCI) (Details) link:presentationLink link:calculationLink link:definitionLink 240844054 - 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Disclosure - Contingencies and commitments (Repatha Patent Litigation) (Details) link:presentationLink link:calculationLink link:definitionLink 241064070 - Disclosure - Contingencies and commitments (Additional Information) (Details) link:presentationLink link:calculationLink link:definitionLink 241074071 - Disclosure - Contingencies and commitments (U.S. Repatriation Tax Commitments) (Details) link:presentationLink link:calculationLink link:definitionLink 211081020 - Disclosure - Quarterly financial data (unaudited) link:presentationLink link:calculationLink link:definitionLink 231093017 - Disclosure - Quarterly financial data (unaudited) (Tables) link:presentationLink link:calculationLink link:definitionLink 241104072 - Disclosure - Quarterly financial data (unaudited) (Details) link:presentationLink link:calculationLink link:definitionLink 211111021 - Disclosure - SCHEDULE II - VALUATION AND QUALIFYING ACCOUNTS link:presentationLink link:calculationLink link:definitionLink 241124073 - 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