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  <xsd:element abstract="true" id="amgn_OtherGovernmentRelatedAndCorporateDebtSecuritiesMember" name="OtherGovernmentRelatedAndCorporateDebtSecuritiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_OtherNotes" name="OtherNotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="amgn_OtherRevenuesMember" name="OtherRevenuesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_OtherShortTermInterestBearingSecuritiesMember" name="OtherShortTermInterestBearingSecuritiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_PaySideMember" name="PaySideMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_PaymentsofContingentConsiderationObligation" name="PaymentsofContingentConsiderationObligation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="amgn_PercentageofNetProfitsAfterDeductingCertainPartnerRelatedCosts" name="PercentageofNetProfitsAfterDeductingCertainPartnerRelatedCosts" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_PercentageofPrincipalAmountofNotesthatmaybePaidUponOccurrenceofChangeinControlTriggeringEvent" name="PercentageofPrincipalAmountofNotesthatmaybePaidUponOccurrenceofChangeinControlTriggeringEvent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_PercentageofRelatedDevelopmentCosts" name="PercentageofRelatedDevelopmentCosts" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ProceedsFromCounterpartiesOnTerminationOfDerivatives" name="ProceedsFromCounterpartiesOnTerminationOfDerivatives" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_PuertoRicoExciseTaxMember" name="PuertoRicoExciseTaxMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_RateAdjustmentToLiborOnInterestRateSwapAgreementsMember" name="RateAdjustmentToLiborOnInterestRateSwapAgreementsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ReceiveSideMember" name="ReceiveSideMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ReclassificationsOutOfAccumulatedOtherComprehensiveIncomeTableTextBlock" name="ReclassificationsOutOfAccumulatedOtherComprehensiveIncomeTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_RestructuringandRelatedCostExpectedCostAcceleratedDepreciationandAssetImpairmentChargesandOtherCosts" name="RestructuringandRelatedCostExpectedCostAcceleratedDepreciationandAssetImpairmentChargesandOtherCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="amgn_RestructuringandRelatedCostExpectedCostSeparationCosts" name="RestructuringandRelatedCostExpectedCostSeparationCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="amgn_ScheduleOfIntangibleAssetsTableTextBlock" name="ScheduleOfIntangibleAssetsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ScheduleOfNotionalAmountsAndInterestRatesForCrossCurrencySwapsTableTextBlock" name="ScheduleOfNotionalAmountsAndInterestRatesForCrossCurrencySwapsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_SeparationCosts" name="SeparationCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SeparationandOtherHeadcountrelatedCostsMember" name="SeparationandOtherHeadcountrelatedCostsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SixPointFourZeroPercentNotesDueTwoZeroThreeNineMember" name="SixPointFourZeroPercentNotesDueTwoZeroThreeNineMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SixPointNineZeroPercentNotesDueTwoZeroThreeEightMember" name="SixPointNineZeroPercentNotesDueTwoZeroThreeEightMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SixPointOneFivePercentNotesDueTwoZeroOneEightMember" name="SixPointOneFivePercentNotesDueTwoZeroOneEightMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SixPointThreeSevenFivePercentNotesDueTwoZeroThreeSevenMember" name="SixPointThreeSevenFivePercentNotesDueTwoZeroThreeSevenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_StatementsOfIncomeAndAmountOfGainRecognizedInIncomeForDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsTableTextBlock" name="StatementsOfIncomeAndAmountOfGainRecognizedInIncomeForDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_StatementsOfIncomeAndEffectivePortionOfGainLossReclassifiedFromAccumulatedOtherComprehensiveIncomeIntoIncomeForOurCashFlowHedgeContractsTableTextBlock" name="StatementsOfIncomeAndEffectivePortionOfGainLossReclassifiedFromAccumulatedOtherComprehensiveIncomeIntoIncomeForOurCashFlowHedgeContractsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_StockRepurchaseProgramTableTextBlock" name="StockRepurchaseProgramTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TermLoanDueTwoThousandEighteenMember" name="TermLoanDueTwoThousandEighteenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointEightSevenFivePercentNotesDueTwoZeroTwoOneMember" name="ThreePointEightSevenFivePercentNotesDueTwoZeroTwoOneMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointFourFivePercentNotesDueTwoZeroTwoZeroMember" name="ThreePointFourFivePercentNotesDueTwoZeroTwoZeroMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointOneTwoFivePercentNotesDueTwoZeroTwoFiveMember" name="ThreePointOneTwoFivePercentNotesDueTwoZeroTwoFiveMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointSixTwentyFivePercentNotesDueTwoThousandTwentyFourMember" name="ThreePointSixTwentyFivePercentNotesDueTwoThousandTwentyFourMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointSixTwoFivePercentNoteDueTwoZeroTwoTwoMember" name="ThreePointSixTwoFivePercentNoteDueTwoZeroTwoTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointFiveZeroPercentNotesDueTwoZeroOneSixMember" name="TwoPointFiveZeroPercentNotesDueTwoZeroOneSixMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointOneTwoFivePercentNoteDueTwoZeroOneSevenMember" name="TwoPointOneTwoFivePercentNoteDueTwoZeroOneSevenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointOneTwoFivePercentNotesDueTwoZeroTwoZeroMember" name="TwoPointOneTwoFivePercentNotesDueTwoZeroTwoZeroMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointSevenZeroPercentNotesDueTwoZeroTwoTwoMember" name="TwoPointSevenZeroPercentNotesDueTwoZeroTwoTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointThreeZeroPercentNotesDueTwoZeroOneSixMember" name="TwoPointThreeZeroPercentNotesDueTwoZeroOneSixMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointTwentyPercentNotesDueTwoThousandNineteenMember" name="TwoPointTwentyPercentNotesDueTwoThousandNineteenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_UnrealizedLossesGainsBeforeReclassifications" name="UnrealizedLossesGainsBeforeReclassifications" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_UponAchievementofAgreedLevelofWorldwideSalesMember" name="UponAchievementofAgreedLevelofWorldwideSalesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_UponAchievementofCertainOtherRegulatoryandSalesrelatedMilestonesMember" name="UponAchievementofCertainOtherRegulatoryandSalesrelatedMilestonesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_UponFirstCommercialSaleintheUSMember" name="UponFirstCommercialSaleintheUSMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
</xsd:schema>
